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  1. Article

    Open Access

    Clinical evaluation of a fully automated and high-throughput molecular testing system for detection of influenza virus

    We investigated the performance of the cobas® 6800 system and cobas SARS-CoV-2 & Influenza A/B, a fully automated molecular testing system for influenza viruses and severe acute respiratory syndrome coronaviru...

    Kosuke Kosai, Norihito Kaku, Michiko Horie, Hina Kodama in Virology Journal (2022)

  2. Article

    Open Access

    Effectiveness of Concomitant Enteral Nutrition Therapy and Infliximab for Maintenance Treatment of Crohn’s Disease in Adults

    One of the problems associated with infliximab (IFX) treatment for Crohn’s disease (CD) is loss of response during maintenance therapy.

    Fumihito Hirai, Hiroshi Ishihara, Shinichirou Yada in Digestive Diseases and Sciences (2013)

  3. No Access

    Article

    Endoscopic snare papillectomy with biliary and pancreatic stent placement for tumors of the major duodenal papilla

    This study aimed to evaluate the feasibility, safety, and follow-up results of endoscopic papilletomy (ESP) with pancreatic and biliary duct stent placement for ampullary tumors. The therapeutic approach to be...

    Takuji Yamao, Hajime Isomoto, Shigeru Kohno, Yohei Mizuta in Surgical Endoscopy (2010)

  4. No Access

    Article

    Factors related to the curability of early gastric cancer with endoscopic submucosal dissection

    Endoscopic submucosal dissection (ESD) yields substantially high rates for curative resection of early gastric cancer (EGC). It is suggested that larger, ulcerative, or upper EGCs may prevent successful ESD. A...

    Ken Ohnita, Hajime Isomoto, Naoyuki Yamaguchi, Eiichiro Fukuda in Surgical Endoscopy (2009)

  5. No Access

    Article

    Intraosseous fat necrosis associated with alcoholic pancreatitis

    A 50-year-old man with a 30-year history of alcohol abuse was admitted because of abdominal pain. Based on an elevated serum amylase level and abdominal computed tomography findings, a diagnosis of alcoholic p...

    Daisuke Norimura, Yohei Mizuta, Kazuo Ohba in Clinical Journal of Gastroenterology (2009)

  6. Article

    Open Access

    Strong Evidence of a Combination Polymorphism of the Tyrosine Kinase 2 Gene and the Signal Transducer and Activator of Transcription 3 Gene as a DNA-Based Biomarker for Susceptibility to Crohn’s Disease in the Japanese Population

    An association between susceptibility to inflammatory bowel disease (IBD) and polymorphisms of both the tyrosine kinase 2 gene (TYK2) and the signal transducer and activator of transcription 3 gene (STAT3) was ex...

    Kayoko Sato, Mizuho Shiota, Sayaka Fukuda, Eiko Iwamoto in Journal of Clinical Immunology (2009)

  7. No Access

    Article

    Polymorphisms of PTPN11 Coding SHP-2 as Biomarkers for Ulcerative Colitis Susceptibility in the Japanese Population

    To identify genetic determinants of inflammatory bowel disease (IBD), we examined an association between polymorphisms of both the programmed cell death 1 gene (PDCD1) and the src homology 2 domain-containing tyr...

    Yukiko Narumi, Hajime Isomoto, Mizuho Shiota, Kayoko Sato in Journal of Clinical Immunology (2009)

  8. No Access

    Article

    Simvastatin Attenuates Trinitrobenzene Sulfonic Acid-Induced Colitis, but Not Oxazalone-Induced Colitis

    Purpose To determine whether simvastatin is able to inhibit inflammation in trinitrobenzene sulfonic acid (TNBS)-induced or oxazalone (OXA)-induced colitis. Results In the prophylactic pr...

    Maho Ikeda, Fuminao Takeshima, Hajime Isomoto in Digestive Diseases and Sciences (2008)

  9. No Access

    Article

    Recent insights into digestive motility in functional dyspepsia

    Functional gastrointestinal disorders, such as functional dyspepsia (FD) and irritable bowel syndrome, are common pathologies of the gut. FD is a clinical syndrome defined as chronic or recurrent pain or disco...

    Yohei Mizuta, Saburo Shikuwa, Hajime Isomoto in Journal of Gastroenterology (2006)

  10. Article

    Open Access

    Expression of HSP47 in Usual Interstitial Pneumonia and Nonspecific Interstitial Pneumonia

    Heat shock protein (HSP) 47, a collagen-specific molecular chaperone, is involved in the processing and/or secretion of procollagens, and its expression is increased in various fibrotic diseases. The aim of th...

    Tomoyuki Kakugawa, Hiroshi Mukae, Tomayoshi Hayashi, Hiroshi Ishii in Respiratory Research (2005)

  11. No Access

    Article

    Flare-up of Autoimmune Hepatitis After Delivery in a Patient with Primary Biliary Cirrhosis: Postpartum Overlap Syndrome of Primary Biliary Cirrhosis and Autoimmune Hepatitis

    Kazuo Ohba, Katsuhisa Omagari, Chika Kusakari in Digestive Diseases and Sciences (2005)

  12. No Access

    Article

    Evaluation of venous thromboembolism and coagulation-fibrinolysis markers in Japanese patients with inflammatory bowel disease

    Arterial or venous thromboembolism is rarely encountered clinically as an extradigestive tract complication in inflammatory bowel disease (IBD). However, it is one of the important prognostic factors for IBD p...

    Koichiro Sonoda, Satoshi Ikeda, Yohei Mizuta in Journal of Gastroenterology (2004)

  13. No Access

    Article

    CASE REPORT: Cyst Formation of Duodenal Heterotopic Pancreas Accompanied by Pancreas Divisum

    Yohei Mizuta, Fuminao Takeshima, Takuji Yamao in Digestive Diseases and Sciences (2004)

  14. No Access

    Article

    Chronic Visceral Hypersensitivity Renders Defecation More Susceptible to Stress via a Serotonergic Pathway in Rats

    Visceral hypersensitivity, intestinal dysmotility, and stress play major roles in irritable bowel syndrome. However, the significance of visceral hypersensitivity in stress-induced changes of colorectal motor ...

    Hitoshi Nishiyama, Yohei Mizuta, Hajime Isomoto in Digestive Diseases and Sciences (2004)

  15. No Access

    Article

    CASE REPORT: Pure Red Cell Aplasia Associated with Parvovirus B19 Infection in a Patient with Ulcerative Colitis

    Hajime Isomoto, Yasuhiro Fukuda, Yumiko Bando in Digestive Diseases and Sciences (2003)

  16. No Access

    Article

    Immune thrombocytopenic purpura in patients with ulcerative colitis

    Extraintestinal manifestations of ulcerative colitis (UC) are well known, but immunologically mediated hematological diseases are relatively rare. We describe two cases of immune thrombocytopenic purpura (ITP)...

    Yohei Mizuta, Hajime Isomoto, Yoshiko Kadokawa, Yuko Akazawa in Journal of Gastroenterology (2003)

  17. No Access

    Article

    Expression of heat shock protein (Hsp) 70 and Hsp 40 in colorectal cancer

    Heat shock protein (Hsp) 70 and Hsp 40 are stress proteins that cooperate as chaperones in mammalian cells. The present study was designed to determine the expression levels of Hsp 70 and Hsp 40 in colorectal ...

    Yusei Kanazawa, Hajime Isomoto MD, Mikio Oka, Yoshitsugu Yano in Medical Oncology (2003)

  18. No Access

    Article

    Influence of Helicobacter pylori infection on in vitro responsiveness of gastric fundus to agonists and to stimulation of enteric nerves in Mongolian gerbils

    It has recently been proposed that disturbed gastric adaptive relaxation may play a role in functional dyspepsia (FD). However, the effect of Helicobacter pylori infection, which may be one of multiple factors a...

    Yusuke Takehara, Yohei Mizuta, Hajime Isomoto, Ken Ohnita in Journal of Gastroenterology (2002)

  19. No Access

    Article

    Ulcerative colitis complicating pseudomembranous colitis of the right colon

    toxin was positive in the feces. The administration of vancomycin in addition to oral steroids resulted in rapid improvement of the condition. Total colonoscopy is recommended for precise diagnosis when patie...

    Ai** Wang, Fuminao Takeshima, Maho Ikeda, Ken Ohnita in Journal of Gastroenterology (2002)

  20. No Access

    Article

    Sludge and stone formation in the gallbladder in bedridden elderly patients with cerebrovascular disease: influence of feeding method

    The incidence of gallbladder sludge or gallstone formation in bedridden patients with cerebrovascular disease (CVD) remains obscure. The aim of this study was to determine the incidence, relationship to feedi...

    Yasunori Onizuka, Yohei Mizuta, Hajime Isomoto in Journal of Gastroenterology (2001)

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