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Article
Doxorubicin eluting beads—2: methods for evaluating drug elution and in-vitro:in-vivo correlation
DC Bead™ is a sulfonate-modified, PVA-based microspherical embolisation agent approved for the treatment of hypervascular tumours and arterio-venous malformations. The beads have previously been shown to activ...
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Article
Open AccessComparison of DC Bead-irinotecan and DC Bead-topotecan drug eluting beads for use in locoregional drug delivery to treat pancreatic cancer
DC Bead® is a drug delivery embolisation system that can be loaded with doxorubicin or irinotecan for the treatment of a variety of liver cancers. In this study we demonstrate that the topoisomerase I inhibitor t...
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Article
Synthesis and characterization of image-able polyvinyl alcohol microspheres for image-guided chemoembolization
Therapeutic embolization of blood vessels is a minimally invasive, catheter-based procedure performed with solid or liquid emboli to treat bleeding, vascular malformations, and vascular tumors. Hepatocellular ...
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Article
Open AccessDC BeadM1™: towards an optimal transcatheter hepatic tumour therapy
Clinical use of DC Bead™ loaded with doxorubicin (DEBDOX™) or irinotecan (DEBIRI™), for the treatment of primary and secondary tumours of the liver respectively, is showing great promise. Recently there has be...
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Article
Open AccessSynthesis, characterisation, and in vitro cellular uptake kinetics of nanoprecipitated poly(2-methacryloyloxyethyl phosphorylcholine)-b-poly(2-(diisopropylamino)ethyl methacrylate) (MPC-DPA) polymeric nanoparticle micelles for nanomedicine applications
Nanoscience offers the potential for great advances in medical technology and therapies in the form of nanomedicine. As such, develo** controllable, predictable, and effective, nanoparticle-based therapeutic...