131 Result(s)
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Yingjun **
Life Sciences
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Article
Open AccessProgrammed Cell Death-Related Gene Signature Associated with Prognosis and Immune Infiltration and the Roles of HMOX1 in the Proliferation and Apoptosis were Investigated in Uveal Melanoma
Uveal melanoma (UVM) is the most common primary ocular malignancy, with a wide range of symptoms and outcomes. The programmed cell death (PCD) plays an important role in tumor development, diagnosis, and progn...
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Article
Low legume-grass seeding ratio combined with phosphorus fertilization promotes forage yield and soil quality in managed grasslands
Legume-grass mixtures are often used to increase forage yield and soil fertility in managed grasslands, but it remains unclear whether these benefits could be further improved by utilizing optimal legume-grass...
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Open AccessPacidusin B isolated from Phyllanthus acidus triggers ferroptotic cell death in HT1080 cells
Cancer cells generally exhibit ‘iron addiction’ phenotypes, which contribute to their vulnerability to ferroptosis inducers. Ferroptosis is a newly discovered form of programmed cell death caused by iron-depen...
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Open AccessA novel easy-to-desorb eluant contributes to address environmental contamination of African swine fever virus
African swine fever virus (ASFV) is a highly pathogenic and rapidly disseminated virus with strong viability in the environment, suggesting the importance of environmental detection for prevention and control ...
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Open AccessA protoplast-based transient gene expression assay for the identification of heat and oxidative stress-regulatory genes in perennial ryegrass
With the accumulating omics data, an efficient and time-saving transient assay to express target genes is desired. Mesophyll protoplasts, maintaining most stress-physiological responses and cellular activities...
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Open AccessSaracatinib prompts hemin-induced K562 erythroid differentiation but suppresses erythropoiesis of hematopoietic stem cells
Human myeloid leukemia cells (such as K562) could be used for the study of erythropoiesis, and mature erythroid markers and globins could be induced during leukemia cell differentiation; however, the pathways ...
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Article
Defoliation, trampling and nutrient return differentially influence grassland productivity by modulating trait-dependent plant community composition: insights from a simulated grazing experiment
Ungulate grazing involves multiple components, including defoliation, dung and urine return, and trampling, which supply offsetting or synergistic effects on plant community composition and productivity (ANPP)...
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Prognostic analysis and risk assessment based on RNA editing in hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is a leading cause of cancer-related mortality, and prognosis assessment is crucial for guiding treatment decisions. In this study, we aimed to develop a personalized prognostic ...
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Open AccessmosGILT controls innate immunity and germ cell development in Anopheles gambiae
Gene-edited mosquitoes lacking a gamma-interferon-inducible lysosomal thiol reductase-like protein, namely (mosGILTnull) have lower Plasmodium infection, which is linked to impaired ovarian development and immune...
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Article
Open AccessAnoikis resistance––protagonists of breast cancer cells survive and metastasize after ECM detachment
Breast cancer exhibits the highest global incidence among all tumor types. Regardless of the type of breast cancer, metastasis is a crucial cause of poor prognosis. Anoikis, a form of apoptosis initiated by ce...
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Article
Open AccessSelective activation of AKAP150/TRPV1 in ventrolateral periaqueductal gray GABAergic neurons facilitates conditioned place aversion in male mice
Aversion refers to feelings of strong dislike or avoidance toward particular stimuli or situations. Aversion can be caused by pain stimuli and has a long-term negative impact on physical and mental health. Ave...
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Genetic dissection of grain morphology and yield components in a wheat line with defective grain filling
We identified stable QTL for grain morphology and yield component traits in a wheat defective grain filling line and validated genetic effects in a panel of cultivars using breeding-relevant markers.
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Article
Tetraspanin Tspan8 restrains interferon signaling to stabilize intestinal epithelium by directing endocytosis of interferon receptor
Inflammation can impair intestinal barrier, while increased epithelial permeability can lead to inflammation. In this study, we found that the expression of Tspan8, a tetraspanin expressed specifically in epit...
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Open AccessOptimization of fermentation conditions for surfactin production by B. subtilis YPS-32
Surfactin produced by microbial fermentation has attracted increasing attention because of its low toxicity and excellent antibacterial activity. However, its application is greatly limited by high production ...
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Open AccessHaplotype-resolved genomes of two buckwheat crops provide insights into their contrasted rutin concentrations and reproductive systems
Two widely cultivated annual buckwheat crops, Fagopyrum esculentum and F. tataricum, differ from each other in both rutin concentration and reproductive system. However, the underlying genetic mechanisms remain p...
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Open AccessMechanical stimulation controls osteoclast function through the regulation of Ca2+-activated Cl− channel Anoctamin 1
Mechanical force loading is essential for maintaining bone homeostasis, and unloading exposure can lead to bone loss. Osteoclasts are the only bone resorbing cells and play a crucial role in bone remodeling. T...
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Article
Migration patterns and conservation status of Asian Great Bustard (Otis tarda dybowskii) in northeast Asia
The Great Bustard (Otis tarda) holds the distinction of the heaviest bird to undertake migration as well as the greatest degree of sexual size dimorphism among living birds. Though the migration of the species ha...
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Prediction of cellular targets in diabetic kidney diseases with single-cell transcriptomic analysis of db/db mouse kidneys
Diabetic kidney disease is the leading cause of impaired kidney function, albuminuria, and renal replacement therapy (dialysis or transplantation), thus placing a large burden on health-care systems. This urge...
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Protocol
Methods to Study RNA–Chromatin Interactions
RNA plays a fundamental role in the organization of chromatin as well as the regulation of gene expression. Although the chromatin is pervasively attached by both coding and noncoding RNAs, the impact of these...
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Article
Fine map** and candidate gene analysis of CRA3.7 conferring clubroot resistance in Brassica rapa
In this study, we fine-mapped a clubroot resistance gene CRA3.7 in Chinese cabbage and developed its closely linked marker syau-InDel3008 for marker-assisted selection in CR cultivars breeding.
