-
Article
Mode transmission performance study of a novel heterogeneous helical cladding fiber with an isolation ring
Large mode area (LMA) fibers are widely used in high power fiber lasers to solve the nonlinear problems. In this work, a novel structure of LMA fiber with heterogeneous helical claddings and an inner isolation...
-
Article
Open AccessHollow carbon fiber wrapped by regular rGO wave-like folds for efficient solar driven interfacial water steam generation
Efficient seawater desalination is an effective way to solve the shortages of fresh water and energy but with limitations of the low fresh water production rate and high cost. Here, a hollow carbon fiber (HCF)...
-
Article
Open AccessSystematic druggable genome-wide Mendelian randomization identifies therapeutic targets for lung cancer
Drug repurposing provides a cost-effective approach to address the need for lung cancer prevention and therapeutics. We aimed to identify actionable druggable targets using Mendelian randomization (MR).
-
Article
Chiral transfer amidst one-dimensional linear polymers and two-dimensional network covalent organic frameworks: Striking a fine balance between helicity and crystallinity
The current landscape of chiral covalent organic frameworks (COFs) predominantly centered on constructing asymmetric molecular-scale chirality, often introducing an inherent contradiction to the COF symmetry a...
-
Article
Value of radiofrequency ablation for treating locally recurrent thyroid cancer: a systematic review and meta-analysis for 2-year follow-up
To evaluate the safety and efficacy of radiofrequency ablation (RFA) in treating locoregional recurrent thyroid cancer (LRTC) after a 2-year follow-up time.
-
Article
Open AccessStructural network disruption of corticothalamic pathways in cerebral small vessel disease
Generalized fractional anisotropy (GFA) can eliminate the crossing fiber effect, which may be more reflective of brain tissue changes in patients with cerebral small vessel disease (CSVD). This study aimed to ...
-
Article
Open AccessPure-high-even-order dispersion bound solitons complexes in ultra-fast fiber lasers
Temporal solitons have been the focus of much research due to their fascinating physical properties. These solitons can form bound states, which are fundamentally crucial modes in fiber laser and present strik...
-
Article
Fibration of powdery materials
Non-destructive processing of powders into macroscopic materials with a wealth of structural and functional possibilities has immeasurable scientific significance and application value, yet remains a challenge...
-
Article
Anisotropic Mechanical Response of Nacre to Heat Treatment Under Indentation: Effect of Structural Orientation
It is generally considered that heat treatments have a negative impact on the mechanical properties of nacre due to thermal decomposition of the organic matrix. However, the present work investigated the micro...
-
Article
Open AccessThe rapid proximity labeling system PhastID identifies ATP6AP1 as an unconventional GEF for Rheb
Rheb is a small G protein that functions as the direct activator of the mechanistic target of rapamycin complex 1 (mTORC1) to coordinate signaling cascades in response to nutrients and growth factors. Despite ...
-
Article
An integrated ceRNA network identifies miR-375 as an upregulated miRNA playing a tumor suppressive role in aggressive prostate cancer
Prostate cancer (PCa) remains a significant cause of morbidity and mortality among men worldwide. A number of genes have been implicated in prostate tumorigenesis, but the mechanisms underlying their dysregula...
-
Article
Open AccessThe association of ROS1 mutation with cancer immunity and its impact on the efficacy of pan-cancer immunotherapy
-
Article
Optimized Nanoscale Mineralization Strategy for Maintaining Bio-enzymatic Stability
Conventional biomineralization strategies are constructed using microparticles, suffering the inhibition of protease bio-availability and required rigorous bio-evaluation. The use of nanomineralization technol...
-
Article
Open AccessMitochondrial (mt)DNA–cyclic GMP–AMP synthase (cGAS)–stimulator of interferon genes (STING) signaling promotes pyroptosis of macrophages via interferon regulatory factor (IRF)7/IRF3 activation to aggravate lung injury during severe acute pancreatitis
Macrophage proinflammatory activation contributes to the pathology of severe acute pancreatitis (SAP) and, simultaneously, macrophage functional changes, and increased pyroptosis/necrosis can further exacerbat...
-
Article
Open AccessMutation of neurotrophic tyrosine receptor kinase can promote pan-cancer immunity and the efficacy of immunotherapy
The Neurotrophic tyrosine receptor kinase (NTRK) family plays important roles in tumor progression and is involved in tumor immunogenicity. Here, we conducted a comprehensive bioinformatic and clinical analysis t...
-
Article
Open AccessDiagnosis model of early Pneumocystis jirovecii pneumonia based on convolutional neural network: a comparison with traditional PCR diagnostic method
Pneumocystis jirovecii pneumonia (PJP) is an interstitial pneumonia caused by pneumocystis jirovecii (PJ). The diagnosis of PJP primarily relies on the detection of the pathogen from lower respiratory tract speci...
-
Article
Open AccessIdentification and analysis of MSC-Exo-derived LncRNAs related to the regulation of EMT in hypospadias
This study aims to screen the differentially expressed long non-coding RNAs (DELncRNAs) related to the regulation of epithelial-mesenchymal transition (EMT) in hypospadias in mesenchymal stem cell-derived exos...
-
Article
Open AccessSex disparities revealed by single-cell and bulk sequencing and their impacts on the efficacy of immunotherapy in esophageal cancer
There is an ongoing debate on whether sex affects immune-suppressive tumor microenvironment and immunotherapy. Here, we explored the underlying molecular bases for sex dimorphisms and their impact on the effic...
-
Article
Open AccessGolden bile powder prevents drunkenness and alcohol-induced liver injury in mice via the gut microbiota and metabolic modulation
Drunkenness and alcoholic liver disease (ALD) are critical public health issues associated with significant morbidity and mortality due to chronic overconsumption of alcohol. Traditional remedies, such as bear...
-
Article
Targeted-activation superparamagnetic spherical nucleic acid nanomachine for ultrasensitive SERS detection of lysozyme based on a bienzymatic-mediated in situ amplification strategy
Lysozyme (LYS) is a widely used bacteriostatic enzyme. In this paper, we built a sensitive and accurate Raman biosensing platform to detect trace amounts of LYS. The method is based on magnetic spherical nucle...
