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Open AccessErythroid-intrinsic activation of TLR8 impairs erythropoiesis in inherited anemia
Inherited non-hemolytic anemia is a group of rare bone marrow disorders characterized by erythroid defects. Although concerted efforts have been made to explore the underlying pathogenetic mechanisms of these ...
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Article
Open AccessPolar Bloch points in strained ferroelectric films
Topological domain structures have drawn great attention as they have potential applications in future electronic devices. As an important concept linking the quantum and classical magnetism, a magnetic Bloch ...
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Open AccesspiRNA loading triggers MIWI translocation from the intermitochondrial cement to chromatoid body during mouse spermatogenesis
The intermitochondrial cement (IMC) and chromatoid body (CB) are posited as central sites for piRNA activity in mice, with MIWI initially assembling in the IMC for piRNA processing before translocating to the ...
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Open AccessNonlinearity association between hyperuricemia and all-cause mortality in patients with chronic kidney disease
Controversy surrounds the role of serum uric acid and whether treatment intervention is favorable in retarding the progression of chronic kidney disease (CKD). The association of serum uric acid levels and CKD...
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Open AccessCoIn dual-atom catalyst for hydrogen peroxide production via oxygen reduction reaction in acid
The two-electron oxygen reduction reaction in acid is highly attractive to produce H2O2, a commodity chemical vital in various industry and household scenarios, which is still hindered by the sluggish reaction ki...
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Open AccessPlasticity in ventral pallidal cholinergic neuron-derived circuits contributes to comorbid chronic pain-like and depression-like behaviour in male mice
Nucleus- and cell-specific interrogation of individual basal forebrain (BF) cholinergic circuits is crucial for refining targets to treat comorbid chronic pain-like and depression-like behaviour. As the ventra...
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Open AccessImmunogenetic losses co-occurred with seahorse male pregnancy and mutation in tlx1 accompanied functional asplenia
In the highly derived syngnathid fishes (pipefishes, seadragons & seahorses), the evolution of sex-role reversed brooding behavior culminated in the seahorse lineage’s male pregnancy, whose males feature a spe...
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Open AccessLow Pt loading for high-performance fuel cell electrodes enabled by hydrogen-bonding microporous polymer binders
A key challenge for fuel cells based on phosphoric acid doped polybenzimidazole membranes is the high Pt loading, which is required due to the low electrode performance owing to the poor mass transport and sev...
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Open AccessSalinity effects on the strength and morphological indices of soft marine clay
This study evaluates the strength behaviors and morphological characteristics of Lianyungang marine clay under the effect of porewater salinity. Soil at higher salinity was found to have increased internal fri...
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Open AccessIn-plane strain engineering in ultrathin noble metal nanosheets boosts the intrinsic electrocatalytic hydrogen evolution activity
Strain has been shown to modulate the electronic structure of noble metal nanomaterials and alter their catalytic performances. Since strain is spatially dependent, it is challenging to expose the active strai...
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Open AccessSteering surface reconstruction of copper with electrolyte additives for CO2 electroreduction
Electrocatalytic CO2 reduction to value-added hydrocarbon products using metallic copper (Cu) catalysts is a potentially sustainable approach to facilitate carbon neutrality. However, Cu metal suffers from unavoi...
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Article
Roton pair density wave in a strong-coupling kagome superconductor
The transition metal kagome lattice materials host frustrated, correlated and topological quantum states of matter1–9. Recently, a new family of vanadium-based kagome metals, AV3Sb5 (A = K, Rb or Cs), with topolo...
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Ultrahigh-energy photons up to 1.4 petaelectronvolts from 12 γ-ray Galactic sources
The extension of the cosmic-ray spectrum beyond 1 petaelectronvolt (PeV; 1015 electronvolts) indicates the existence of the so-called PeVatrons—cosmic-ray factories that accelerate particles to PeV energies. We n...
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Open AccessGenome sequences reveal global dispersal routes and suggest convergent genetic adaptations in seahorse evolution
Seahorses have a circum-global distribution in tropical to temperate coastal waters. Yet, seahorses show many adaptations for a sedentary, cryptic lifestyle: they require specific habitats, such as seagrass, k...
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Open AccessA new Majorana platform in an Fe-As bilayer superconductor
Iron-chalcogenide superconductors have emerged as a promising Majorana platform for topological quantum computation. By combining topological band and superconductivity in a single material, they provide signi...
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Open AccessLocalized spin-orbit polaron in magnetic Weyl semimetal Co3Sn2S2
The kagome lattice Co3Sn2S2 exhibits the quintessential topological phenomena of a magnetic Weyl semimetal such as the chiral anomaly and Fermi-arc surface states. Probing its magnetic properties is crucial for u...
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Open AccessOral delivery of xenon for cardiovascular protection
Cardiac hypertrophy often causes impairment of cardiac function. Xenon (Xe), a naturally occurring noble gas, is known to provide neurological and myocardial protection without side effects. The conventional m...
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Glucose-regulated phosphorylation of TET2 by AMPK reveals a pathway linking diabetes to cancer
Diabetes is a complex metabolic syndrome that is characterized by prolonged high blood glucose levels and frequently associated with life-threatening complications1,2. Epidemiological studies have suggested that ...
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Open AccessWhole-genome sequencing reveals genomic signatures associated with the inflammatory microenvironments in Chinese NSCLC patients
Chinese lung cancer patients have distinct epidemiologic and genomic features, highlighting the presence of specific etiologic mechanisms other than smoking. Here, we present a comprehensive genomic landscape ...
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Open AccessClimates on incidence of childhood type 1 diabetes mellitus in 72 countries
We are aimed to systematically assess the worldwide trend in incidence of childhood type 1 diabetes mellitus (CT1DM) from 1965 to 2012 and to discuss whether climate affect incidence of CT1DM. We searched the ...