37 Result(s)
within
Yin-** Geng
Life Sciences
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Article
Physiological and biochemical changes in leaf abscission of Cyclocarya paliurus stem segments in vitro
Leaf abscission of Cyclocarya paliurus stem segments is extremely serious in vitro and seriously hinders the rapid propagation process of C. paliurus. To explore the physiological and biochemical responses of lea...
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Open AccessA novel c-Met/TRK inhibitor 1D228 efficiently inhibits tumor growth by targeting angiogenesis and tumor cell proliferation
Multiple tumors are synergistically promoted by c-Met and TRK, and blocking their cross-signalling pathway may give better effects. In this study, we developed a tyrosine kinase inhibitor 1D228, which exhibite...
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Open AccessAbnormal developmental trajectory and vulnerability to cardiac arrhythmias in tetralogy of Fallot with DiGeorge syndrome
Tetralogy of Fallot (TOF) is the most common cyanotic congenital heart disease. Ventricular dysfunction and cardiac arrhythmias are well-documented complications in patients with repaired TOF. Whether intrinsi...
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Article
Upregulation of Wilms’ Tumor 1 in epicardial cells increases cardiac fibrosis in dystrophic mice
Cardiomyopathy is a primary cause of mortality in Duchenne muscular dystrophy (DMD) patients. Mechanistic understanding of cardiac fibrosis holds the key to effective DMD cardiomyopathy treatments. Here we dem...
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Open AccessApplication of Bone Marrow Mesenchymal Stem Cells Effectively Eliminates Endotoxemia to Protect Rat from Acute Liver Failure Induced by Thioacetamide
Endotoxemia is related to worse clinical outcomes in acute liver failure (ALF), but its management remains unsatisfactory. In this study, we aimed to assess whether the application of bone marrow mesenchymal s...
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Article
Enhanced genome editing to ameliorate a genetic metabolic liver disease through co-delivery of adeno-associated virus receptor
Genome editing through adeno-associated viral (AAV) vectors is a promising gene therapy strategy for various diseases, especially genetic disorders. However, homologous recombination (HR) efficiency is extreme...
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Clarification of the etiology of peach bacteria leaf shot hole caused by Pantoea spp. in Henan Province, China, based on morphological characteristics and multi-locus sequences analysis
Peach bacteria leaf shot hole is a commonly occurring foliar disease of economic importance, which severely affects the host photosynthesis and contributes to substantial losses in yield each year. To date, ho...
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Article
Omega-3 fatty acid protects cardiomyocytes against hypoxia-induced injury through targeting MiR-210-3p/CASP8AP2 axis
MicroRNAs (miRs) regulate diverse biological functions in both normal and pathological cellular conditions by post-transcriptional regulation of various genes expression. Nevertheless, the role of miRs in regu...
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Article
The sub-inhibitory concentration of cinnamaldehyde resists Aeromonas hydrophila pathogenicity via inhibition of W-pili production
Aeromonas hydrophila is one of the most important pathogens of zoonotic importance globally, causing various diseases in humans and animals. With the increase of drug resistance and the emergence of multidrug-res...
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Article
Open AccessLMNB2 promotes the progression of colorectal cancer by silencing p21 expression
Colorectal cancer is the second common cause of death worldwide. Lamin B2 (LMNB2) is involved in chromatin remodeling and the rupture and reorganization of nuclear membrane during mitosis, which is necessary f...
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Article
Open AccessAutophagy impairment as a key feature for acetaminophen-induced ototoxicity
Macroautophagy/autophagy is a highly conserved self-digestion pathway that plays an important role in cytoprotection under stress conditions. Autophagy is involved in hepatotoxicity induced by acetaminophen (A...
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Open AccessCorrection to: Complete genome analysis of a virulent Vibrio scophthalmi strain VSc190401 isolated from diseased marine fish half-smooth tongue sole, Cynoglossus semilaevis
An amendment to this paper has been published and can be accessed via the original article.
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Article
Open AccessComplete genome analysis of a virulent Vibrio scophthalmi strain VSc190401 isolated from diseased marine fish half-smooth tongue sole, Cynoglossus semilaevis
Vibrio scophthalmi is an opportunistic bacterial pathogen, which is widely distributed in the marine environment. Earlier studies have suggested that it is a normal microorganism in the turbot gut. However, recen...
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Article
Antibacterial effect of Blumea balsamifera DC. essential oil against Haemophilus parasuis
Haemophilus parasuis (H. parasuis), the cause of the Glasser’s disease, is a potentially pathogenic gram-negative organism that colonizes the upper respiratory tract of pigs. The extraction of Blumea balsamifera ...
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Article
Hippo kinases MST1 and MST2 control the differentiation of the epididymal initial segment via the MEK-ERK pathway
Although the roles of the Hippo pathway in organogenesis and tumorigenesis have been well studied in multiple organs, its role in sperm maturation and male fertility has not been investigated. The initial segm...
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Article
Identification of mecciRNAs and their roles in the mitochondrial entry of proteins
Mammalian mitochondria have small genomes encoding very limited numbers of proteins. Over one thousand proteins and noncoding RNAs encoded by the nuclear genome must be imported from the cytosol into the mitoc...
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Article
Dual base editor catalyzes both cytosine and adenine base conversions in human cells
Although base editors are useful tools for precise genome editing, current base editors can only convert either adenines or cytosines. We developed a dual adenine and cytosine base editor (A&C-BEmax) by fusing...
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Open AccessSuccessful delivery of large-size CRISPR/Cas9 vectors in hard-to-transfect human cells using small plasmids
With the rise of new powerful genome engineering technologies, such as CRISPR/Cas9, cell models can be engineered effectively to accelerate basic and disease research. The most critical step in this procedure ...
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Open AccessNetwork-directed efficient isolation of previously uncultivated Chloroflexi and related bacteria in hot spring microbial mats
The perplexity of the complex multispecies community interactions is one of the many reasons why majority of the microorganisms are still uncultivated. We analyzed the entire co-occurrence networks between the...
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Article
Outbreak of carp edema virus disease in cultured ornamental koi in a lower temperature in China
Carp edema virus (CEV) is the pathogen of carp edema virus disease (CEVD), an emerging infectious disease with high morbidity and mortality worldwide. In the winter of 2016, a disease outbreak occurred in a ko...
