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Article
Open AccessAdhere to the Chinese dietary guidelines associated with better subjective well-being: evidence from a cross-sectional survey and a daily diary investigation
Subjective well-being (SWB) plays an essential role in general health. Although beneficial effects of selected micronutrients and foods on SWB have been reported, they do not reflect the impact of the habitual...
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Article
Design strategies for rechargeable aqueous metal-ion batteries
Rechargeable aqueous metal-ion batteries (AMBs) have attracted extensive scientific and commercial interest due to their potential for cost-effective, highly safe, and scalable stationary energy storage. Howev...
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Article
Extended reality for biomedicine
Extended reality (XR) refers to an umbrella of methods that allows users to be immersed in a 3D or a 4D (spatial + temporal) virtual environment to various extents, including virtual reality (VR), augmented re...
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Article
Computational Analysis of Cardiac Contractile Function
Heart failure results in the high incidence and mortality all over the world. Mechanical properties of myocardium are critical determinants of cardiac function, with regional variations in myocardial contracti...
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Article
Open AccessGenome-centric analysis of short and long read metagenomes reveals uncharacterized microbiome diversity in Southeast Asians
Despite extensive efforts to address it, the vastness of uncharacterized ‘dark matter’ microbial genetic diversity can impact short-read sequencing based metagenomic studies. Population-specific biases in geno...
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Article
Modulations of face perception in response to a novel time-varying optical perturbation after aberration correction using adaptive optics
The role of time in the perception of optical perturbation has received little attention. We sought to establish a novel time-varying perturbation in an image sequence using adaptive optics. We introduced the ...
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Article
Real-time volumetric reconstruction of biological dynamics with light-field microscopy and deep learning
Light-field microscopy has emerged as a technique of choice for high-speed volumetric imaging of fast biological processes. However, artifacts, nonuniform resolution and a slow reconstruction speed have limite...
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Protocol
In Vivo Clonal Analysis of Cardiomyocytes
The development of the CreER/LoxP system has enabled temporal control and cell type specificity of gene activation or repression. A common application of this system involves lineage tracing and examining the ...
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Article
Open AccessPopulation dynamics and transcriptomic responses of Pseudomonas aeruginosa in a complex laboratory microbial community
Pseudomonas aeruginosa tends to be among the dominant species in multi-species bacterial consortia in diverse environments. To understand P. aeruginosa’s physiology and interactions with co-existing bacterial spe...
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Article
Open AccessIn vivo long-term investigation of tumor bearing mKate2 by an in-house fluorescence molecular imaging system
Optical imaging is one of the most common, low-cost imaging tools used for investigating the tumor biological behavior in vivo. This study explores the feasibility and sensitivity of a near infrared fluorescen...
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Article
Simulating Developmental Cardiac Morphology in Virtual Reality Using a Deformable Image Registration Approach
While virtual reality (VR) has potential in enhancing cardiovascular diagnosis and treatment, prerequisite labor-intensive image segmentation remains an obstacle for seamlessly simulating 4-dimensional (4-D, 3...
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Article
Open AccessCharacterization of a novel multidrug resistance plasmid pSGB23 isolated from Salmonella enterica subspecies enterica serovar Saintpaul
Salmonella enterica subspecies enterica serovar Saintpaul (S. Saintpaul) is an important gut pathogen which causes salmonellosis worldwide. Although intestinal salmonellosis is usually self-limiting, it can be li...
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Article
Open AccessAcquisition of resistance to carbapenem and macrolide-mediated quorum sensing inhibition by Pseudomonas aeruginosa via ICETn43716385
Pseudomonas aeruginosa can cause life-threatening infections in immunocompromised patients. The first-line agents to treat P. aeruginosa infections are carbapenems. However, the emergence of carbapenem-resistant
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Article
Light-Sheet Imaging to Elucidate Cardiovascular Injury and Repair
Real-time 3-dimensional (3-D) imaging of cardiovascular injury and regeneration remains challenging. We introduced a multi-scale imaging strategy that uses light-sheet illumination to enable applications of ca...
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Article
Open AccessAnalysis of cardiomyocyte clonal expansion during mouse heart development and injury
The cellular mechanisms driving cardiac tissue formation remain poorly understood, largely due to the structural and functional complexity of the heart. It is unclear whether newly generated myocytes originate...
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Article
Open AccessIdentification of a biosynthetic gene cluster for the polyene macrolactam sceliphrolactam in a Streptomyces strain isolated from mangrove sediment
Streptomyces are a genus of Actinobacteria capable of producing structurally diverse natural products. Here we report the isolation and characterization of a biosynthetically talented Streptomyces (Streptomyces s...
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Article
Validation of Bevacizumab Therapy Effect on Colon Cancer Subtypes by Using Whole Body Imaging in Mice
Preclinical imaging offers a useful tool for monitoring cancer biological behavior and therapy in vivo without the necessity of animal surgery. The following paper describes our examination of tumor progress and ...
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Article
Anti-bacterial properties of collagen-coated glass and polydimethylsiloxane substrates
Attachments of three bacterial species, Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa on chemically modified glass slides and polydimethylsiloxane substrates were investigated with an attemp...
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Article
Open AccessAutomated Segmentation of Light-Sheet Fluorescent Imaging to Characterize Experimental Doxorubicin-Induced Cardiac Injury and Repair
This study sought to develop an automated segmentation approach based on histogram analysis of raw axial images acquired by light-sheet fluorescent imaging (LSFI) to establish rapid reconstruction of the 3-D z...
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Article
Open AccessInductively powered wireless pacing via a miniature pacemaker and remote stimulation control system
Pacemakers have existed for decades as a means to restore cardiac electrical rhythms. However, lead-related complications have remained a clinical challenge. While market-released leadless devices have address...
