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Article
Open AccessSkeletal muscle index together with body mass index is associated with secondary osteoporosis in patients with rheumatoid arthritis
The objective of this study was to explore the associations of body mass index (BMI), fat mass index (FMI), skeletal mass index (SMI) and secondary osteoporosis (OP) in patients with rheumatoid arthritis (RA).
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Article
The roles of ETS transcription factors in liver fibrosis
E26 transformation specific or E twenty-six (ETS) protein family consists of 28 transcription factors, five of which, named ETS1/2, PU.1, ERG and EHF, are known to involve in the development of liver fibrosis,...
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Article
Open AccessConcurrent definitive chemoradiation incorporating intensity-modulated radiotherapy followed by adjuvant chemotherapy in high risk locally advanced cervical squamous cancer: a phase II study
Although the prognosis of locally advanced cervical cancer has improved dramatically, survival for those with stage IIIB-IVA disease or lymph nodes metastasis remains poor. It is believed that the incorporatio...
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Article
Combined analysis of receptor expression reflects inter-and intra-tumor heterogeneity in HR+/HER2+ breast cancer
Hormone receptor-positive and human epidermal growth factor receptor 2-positive (HR+/HER2+ breast cancer comprise approximately 5–10% of all invasive breast cancers. However, the lack of knowledge regarding th...
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Article
Open AccessThrombospondin-2 holds prognostic value and is associated with metastasis and the mismatch repair process in gastric cancer
This study aims to investigate thrombospondin 2 (TSP2) expression levels in gastric cancer (GC) and determine the relationship between TSP2 and clinical characteristics and prognosis.
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Article
Open AccessComputed tomographic features of adenoid cystic carcinoma in the palate
To evaluate the computed tomographic features and create a prediction model for clinical diagnosis of adenoid cystic carcinoma (ACC) in the palate with intact mucosa.
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Article
Open AccessMutation allele frequency threshold does not affect prognostic analysis using next-generation sequencing in oral squamous cell carcinoma
With the development of sequencing technologies, there may be some disputes on sequencing analysis. The aim of this study was to investigate different allele frequency thresholds of mutations in targeted genes...
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Article
Open AccessMetformin can block precancerous progression to invasive tumors of bladder through inhibiting STAT3-mediated signaling pathways
Metformin is the first line of oral antidiabetic drug in the biguanide class for treatment of type 2 diabetes. Increasing evidence has suggested that it is a potential anti-tumor drug. However, the mechanisms ...
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Article
Inhibitor of differentiation 1 is a candidate prognostic marker in multicentric Castleman’s disease
Castleman’s disease (CD) is a benign lymphoproliferative disorder characterized by dysfunctional lymphatic node hyperplasia. Lymphatic node hyperplasia is associated with elevated levels of inhibitor of differ...
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Article
AEG-1 is associated with tumor progression in nonmuscle-invasive bladder cancer
Astrocyte elevated gene-1 (AEG-1), a novel oncoprotein, has been implicated in oncogenesis and cancer progression in various types of human cancers. Here, immunohistochemistry was used to detect AEG-1 express...
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Article
Increased expression of forkhead box M1 protein is associated with poor prognosis in clear cell renal cell carcinoma
Forkhead box protein M1 (FoxM1) is crucial in the regulation of various biological processes, including cell proliferation, organogenesis, and angiogenesis. Overexpression of FoxM1 is associated with carcinoge...
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Article
UHRF1 is associated with tumor recurrence in non-muscle-invasive bladder cancer
Ubiquitin-like with PHD and ring finger domains 1 (UHRF1) is a novel anti-apoptotic gene, and overexpression of UHRF1 is involved in tumorigenicity. Here, immunohistochemistry was used to detect UHRF1 expressi...