88 Result(s)

Article

Exome sequencing and genome-wide association analyses unveils the genetic predisposition in hydroxychloroquine retinopathy

To unveil the candidate susceptibility genes in chloroquine/hydroxychloroquine (CQ/HCQ) retinopathy using whole exome sequencing (WES) and genome-wide association study (GWAS).

Hsun-I Chiu, Hui-Chen Cheng, Chih-Chiau Wu, Shih-Jen Chen, De-Kuang Hwang… in Eye (2024)

Article

Network analysis of comorbid aggressive behavior and testosterone among bipolar disorder patients: a cross-sectional study

Testosterone has complex effects on psychological traits and behavior; it is associated with social dominance and competition and is a potential human sex pheromone. This study aimed to investigate the associa...

Yi Liu, Hong Cai, Tian Han, Yi-Fan Wang, Juan Li, **ao-meng **e… in Translational Psychiatry (2024)

Article

Correlating Reiff scores with clinical, functional, and prognostic factors: characterizing noncystic fibrosis bronchiectasis severity: validation from a nationwide multicenter study in Taiwan

Our study aimed to confirm a simplified radiological scoring system, derived from a modified Reiff score, to evaluate its relationship with clinical symptoms and predictive outcomes in Taiwanese patients with ...

Wen-Chien Cheng, Chia-Ling Chang, Chau-Chyun Sheu… in European Journal of Medical Research (2024)

Article

Pharmaceutical treatment status of patients with COPD in the community based on medical Internet of Things: a real-world study

This study aimed to investigate the real-world standardisation and adherence of medical treatment regimens in patients with chronic obstructive pulmonary disease (COPD) in the community for making future manag...

Peng Wu, Yi-qun Jiang, Feng-li Si, Huan-ying Wang… in npj Primary Care Respiratory Medicine (2024)

Article

The potential association between metabolic disorders and pulmonary tuberculosis: a Mendelian randomization study

Metabolic disorders (MetDs) have been demonstrated to be closely linked to numerous diseases. However, the precise association between MetDs and pulmonary tuberculosis (PTB) remains poorly understood.

Zhi-xiang Du, Yun-yao Ren, Jia-luo Wang… in European Journal of Medical Research (2024)

Article

Identifying flaws in the GWAS datasets of a published Mendelian randomization study: complementary re-evaluation and suggestion for analytical refinements

Jia-Cheng **ang, Yi-Fan **ong, Shao-Gang Wang… in Journal of Translational Medicine (2024)

Article

β-Receptor blocker enhances the anabolic effect of PTH after osteoporotic fracture

The autonomic nervous system plays a crucial role in regulating bone metabolism, with sympathetic activation stimulating bone resorption and inhibiting bone formation. We found that fractures lead to increased...

Jie Huang, Tong Wu, Yi-Rong Jiang, Xuan-Qi Zheng, Huan Wang, Hao Liu… in Bone Research (2024)

Article

The optimal antithrombotic strategy for post-stroke patients with atrial fibrillation and extracranial artery stenosis—a nationwide cohort study

In post-stroke atrial fibrillation (AF) patients who have indications for both oral anticoagulant (OAC) and antiplatelet agent (AP), e.g., those with carotid artery stenosis, there is debate over the best anti...

Chuan-Tsai Tsai, Yi-Hsin Chan, Jo-Nan Liao, Tzeng-Ji Chen… in BMC Medicine (2024)

Article

Progesterone receptor potentiates macropinocytosis through CDC42 in pancreatic ductal adenocarcinoma

Endocrine receptors play an essential role in tumor metabolic reprogramming and represent a promising therapeutic avenue in pancreatic ductal adenocarcinoma (PDAC). PDAC is characterized by a nutrient-deprived...

Ying-Na Liao, Yan-Zhi Gai, Li-Heng Qian, Hong Pan, Yi-Fan Zhang, Pin Li… in Oncogenesis (2024)

Article

ER-positive and BRCA2-mutated breast cancer: a literature review

BRCA2-mutated carriers have a high lifetime risk of breast cancer (BC), an early age of onset, and an increased risk of other cancers (including ovarian, pancreatic, and prostate cancer). Almost 70–80% of BRCA2-m...

Pu-Chun Li, Yi-Fan Zhu, Wen-Ming Cao, Bei Li in European Journal of Medical Research (2024)

Article

Entecavir versus tenofovir for prevention of hepatitis B virus-associated hepatocellular carcinoma after curative resection: study protocol for a randomized, open-label trial

Entecavir and tenofovir disoproxil fumarate (TDF) are standard first-line treatments to prevent viral reactivation and hepatocellular carcinoma (HCC) in individuals chronically infected with the hepatitis B vi...

Li-**n Pan, Yi-Yang Wang, Zhong-Hai Li, Jia-** Luo, Kun-Jun Wu, Zhen-**u Liu… in Trials (2024)

Article

Trends and projections of inflammatory bowel disease at the global, regional and national levels, 1990–2050: a bayesian age-period-cohort modeling study

Inflammatory bowel disease (IBD) is a global health concern with varying levels and trends across countries and regions. Understanding these differences is crucial for effective prevention and treatment strate...

Jia-Li Zhou, Jia-Chen Bao, Xu-Ying Liao, Yi-Jia Chen, Lin-Wei Wang… in BMC Public Health (2023)

Article

Antigen-induced chimeric antigen receptor multimerization amplifies on-tumor cytotoxicity

Ligand-induced receptor dimerization or oligomerization is a widespread mechanism for ensuring communication specificity, safeguarding receptor activation, and facilitating amplification of signal transduction...

Yan Sun, **u-Na Yang, Shuang-Shuang Yang… in Signal Transduction and Targeted Therapy (2023)

Article

Suicidality and its associated factors among mood disorder patients in emergency department in China: a comparative study using propensity score matching approach

Suicidality in mood disorder patients is common, especially in emergency department (ED), but the patterns and associated factors of suicidality are not clear. This study compared biomarkers and mental health ...

**ao-meng **e, Yi-Fan Wang, Tian Han, Yi Liu, Juan Li, Hui Zhu… in Translational Psychiatry (2023)

Article

Small extrachromosomal circular DNA harboring targeted tumor suppressor gene mutations supports intratumor heterogeneity in mouse liver cancer induced by multiplexed CRISPR/Cas9

Primary liver cancer has significant intratumor genetic heterogeneity (IGH), which drives cancer evolution and prevents effective cancer treatment. CRISPR/Cas9-induced mouse liver cancer models can be used to ...

Tao Guo, Guo-Qiao Chen, Xu-Fan Li, Meng Wang, Kun-Ming Liu… in Genome Medicine (2023)

Article

Amino acid metabolism in health and disease

Amino acids are the building blocks of protein synthesis. They are structural elements and energy sources of cells necessary for normal cell growth, differentiation and function. Amino acid metabolism disorder...

Zhe-Nan Ling, Yi-Fan Jiang, Jun-Nan Ru… in Signal Transduction and Targeted Therapy (2023)

Article

Effects of mixed oil emulsion on short-term clinical outcomes in premature infants: A prospective, multicenter, randomized controlled trial

This study compared the clinical effects of two different lipid emulsions in premature infants with gestational age < 32 weeks (VPI) or birth weight < 1500 g (VLBWI) to provide an evidence-based medicine basis...

Qing Yang, Juan Kong, Rui-Miao Bai, Wen-Ting Yu… in European Journal of Clinical Nutrition (2023)

Article

Network analysis of comorbid depression, suicidality and biomarkers on HPA axis among mood disorder patients to psychiatric emergency services

Rapid assessment and intervention of suicide risk are common and challenging in psychiatric emergency departments (PED). It is unclear whether distinct pathophysiological processes exist among depressive patie...

Yi-Fan Wang, Guang-yun You, Tian Han, Yi Liu, Juan Li, **ao Ji… in Translational Psychiatry (2023)

Article

Divergent projections of the prelimbic cortex mediate autism- and anxiety-like behaviors

The comorbidity of autism spectrum disorder and anxiety is common, but the underlying circuitry is poorly understood. Here, Tmem74^-/- mice showed autism- and anxiety-like behaviors along with increased excitabili...

Yi-Fan Luo, Lu Lu, Heng-Yi Song, Han Xu, Zhi-Wei Zheng, Zhou-Yue Wu… in Molecular Psychiatry (2023)

Article

Effects of neoadjuvant radiochemotherapy for anorectal function in locally advanced rectal cancer patients: a study protocol for a prospective, observational, controlled, multicentre study

Neoadjuvant chemoradiotherapy (NCRT) and total mesorectal excision are standard treatment regimen for patients with locally advanced rectal cancer (LARC). This sphincter-saving treatment strategy may be accomp...

Jie Shi, Yi-Kan Cheng, Fang He, Jian Zheng, Yun-Long Wang, **ang-Bo Wan… in BMC Cancer (2023)