12 Result(s)

Article

Antigen-induced chimeric antigen receptor multimerization amplifies on-tumor cytotoxicity

Ligand-induced receptor dimerization or oligomerization is a widespread mechanism for ensuring communication specificity, safeguarding receptor activation, and facilitating amplification of signal transduction...

Yan Sun, **u-Na Yang, Shuang-Shuang Yang… in Signal Transduction and Targeted Therapy (2023)

Article

Amino acid metabolism in health and disease

Amino acids are the building blocks of protein synthesis. They are structural elements and energy sources of cells necessary for normal cell growth, differentiation and function. Amino acid metabolism disorder...

Zhe-Nan Ling, Yi-Fan Jiang, Jun-Nan Ru… in Signal Transduction and Targeted Therapy (2023)

Article

Toripalimab combined with lenvatinib and GEMOX is a promising regimen as first-line treatment for advanced intrahepatic cholangiocarcinoma: a single-center, single-arm, phase 2 study

Advanced intrahepatic cholangiocarcinoma (ICC) has a dismal prognosis. Here, we report the efficacy and safety of combining toripalimab, lenvatinib, and gemcitabine plus oxaliplatin (GEMOX) as first-line thera...

Guo-Ming Shi, **ao-Yong Huang, Dong Wu… in Signal Transduction and Targeted Therapy (2023)

Article

Blockade of NMT1 enzymatic activity inhibits N-myristoylation of VILIP3 protein and suppresses liver cancer progression

Hepatocellular carcinoma (HCC) is one of the most common malignant tumors. Identification of the underlying mechanism of HCC progression and exploration of new therapeutic drugs are urgently needed. Here, a co...

**ang-Peng Tan, Yan He, **g Yang, **an Wei… in Signal Transduction and Targeted Therapy (2023)

Article

The sirtuin family in health and disease

Sirtuins (SIRTs) are nicotine adenine dinucleotide(+)-dependent histone deacetylases regulating critical signaling pathways in prokaryotes and eukaryotes, and are involved in numerous biological processes. Cur...

Qi-Jun Wu, Tie-Ning Zhang, Huan-Huan Chen… in Signal Transduction and Targeted Therapy (2022)

Article

Whole-genome sequencing reveals the evolutionary trajectory of HBV-related hepatocellular carcinoma early recurrence

Patients with hepatocellular carcinoma (HCC) have poor long-term survival following curative resection because of the high rate of tumor early recurrence. Little is known about the trajectory of genomic evolut...

Shao-Lai Zhou, Zheng-Jun Zhou, Cheng-Li Song… in Signal Transduction and Targeted Therapy (2022)

Article

Interleukin-37 promotes colitis-associated carcinogenesis via SIGIRR-mediated cytotoxic T cells dysfunction

Interleukin-37b (hereafter called IL-37) was identified as fundamental inhibitor of natural and acquired immunity. The molecular mechanism and function of IL-37 in colorectal cancer (CRC) has been elusive. Her...

Zhen Wang, Fan-lian Zeng, Ya-wen Hu… in Signal Transduction and Targeted Therapy (2022)

Article

Detection of an anti-angina therapeutic module in the effective population treated by a multi-target drug Danhong injection: a randomized trial

It’s a challenge for detecting the therapeutic targets of a polypharmacological drug from variations in the responsed networks in the differentiated populations with complex diseases, as stable coronary heart ...

Jun Liu, Dan-Dan Li, Wei Dong, Yu-Qi Liu… in Signal Transduction and Targeted Therapy (2021)

Article

Clinical effect and antiviral mechanism of T-705 in treating severe fever with thrombocytopenia syndrome

Severe fever with thrombocytopenia syndrome (SFTS) virus (SFTSV) is an emerging tick-borne virus with high fatality and an expanding endemic. Currently, effective anti-SFTSV intervention remains unavailable. F...

Hao Li, **a-Ming Jiang, Ning Cui, Chun Yuan… in Signal Transduction and Targeted Therapy (2021)

Article

The effect of whey protein on viral infection and replication of SARS-CoV-2 and pangolin coronavirus in vitro

Huahao Fan, Bixia Hong, Yuqian Luo, Qi Peng… in Signal Transduction and Targeted Therapy (2020)

Article

Acetylation promotes BCAT2 degradation to suppress BCAA catabolism and pancreatic cancer growth

Pancreatic ductal adenocarcinoma (PDAC) is well-known for inefficient early diagnosis, with most patients diagnosed at advanced stages. Increasing evidence indicates that elevated plasma levels of branched-cha...

Ming-Zhu Lei, Xu-Xu Li, Ye Zhang, **-Tao Li… in Signal Transduction and Targeted Therapy (2020)