3 Result(s)

Article

Small extrachromosomal circular DNA harboring targeted tumor suppressor gene mutations supports intratumor heterogeneity in mouse liver cancer induced by multiplexed CRISPR/Cas9

Primary liver cancer has significant intratumor genetic heterogeneity (IGH), which drives cancer evolution and prevents effective cancer treatment. CRISPR/Cas9-induced mouse liver cancer models can be used to ...

Tao Guo, Guo-Qiao Chen, Xu-Fan Li, Meng Wang, Kun-Ming Liu… in Genome Medicine (2023)

Article

The genomic architecture of EBV and infected gastric tissue from precursor lesions to carcinoma

Epstein-Barr virus (EBV)-associated gastric carcinomas (EBVaGCs) present unique molecular signatures, but the tumorigenesis of EBVaGCs and the role EBV plays during this process remain poorly understood.

Zhang-Hua Chen, Shu-Mei Yan, **-** Chen, Qi Zhang, Shang-**n Liu… in Genome Medicine (2021)

Article

Comprehensive quantitation of metabolite concentrations, gross reaction fluxes, and reaction free energies across cells from four organisms

Junyoung Park, Sara Rubin, Yi-Fan Xu, Daniel Amador-Noguez, **g Fan… in Cancer & Metabolism (2014)