141 Result(s)

Article

Author Correction: High-speed and large-scale intrinsically stretchable integrated circuits

Donglai Zhong, Can Wu, Yuanwen Jiang, Yujia Yuan, Min-gu Kim, Yuya Nishio… in Nature (2024)

Article

High-throughput sequencing-based analysis of the composition and diversity of the endophyte community in roots of Stellera chamaejasme

Stellera chamaejasme (S. chamaejasme) is an important medicinal plant with heat-clearing, detoxifying, swelling and anti-inflammatory effects. At the same time, it is also one of the iconic plants of natural gras...

Jun-ze Zhang, **n-zhong Li, Ye-bing Yin, Si-cen Luo, Dong-xu Wang… in Scientific Reports (2024)

Article

Clinical phenotype and genetic function analysis of a family with hypomyelinating leukodystrophy-7 caused by POLR3A mutation

Hypomyelinating leukodystrophy (HLD) is a rare genetic heterogeneous disease that can affect myelin development in the central nervous system. This study aims to analyze the clinical phenotype and genetic func...

Dan-dan Ruan, **ng-lin Ruan, Ruo‑li Wang, **n-fu Lin, Yan-** Zhang… in Scientific Reports (2024)

Article

HFpEF as systemic disease, insight from a diagnostic prediction model reminiscent of systemic inflammation and organ interaction in HFpEF patients

Systemic inflammation and reciprocal organ interactions are associated with the pathophysiology of heart failure with preserved ejection fraction (HFpEF). However, the clinical value, especially the diagnositc...

Rong Zhou, Yi-Yuan **a, Zheng Li, Li-Da Wu, Yi Shi, Zhi-Yu Ling… in Scientific Reports (2024)

Article

Genetic drivers of heterogeneity in type 2 diabetes pathophysiology

Type 2 diabetes (T2D) is a heterogeneous disease that develops through diverse pathophysiological processes^1,2 and molecular mechanisms that are often specific to cell type^3,4. Here, to characterize the genetic c...

Ken Suzuki, Konstantinos Hatzikotoulas, Lorraine Southam, Henry J. Taylor… in Nature (2024)

Article

Microbes translocation from oral cavity to nasopharyngeal carcinoma in patients

The presence of oral microbes in extra-oral sites is linked to gastrointestinal cancers. However, their potential ectopically colonization in the nasopharynx and impact on local cancer development remains unce...

Ying Liao, Yan-**a Wu, Minzhong Tang, Yi-Wei Chen, **-Ru **e… in Nature Communications (2024)

Article

A chromosome-level genome assembly of the forestry pest Coronaproctus castanopsis

As an important forestry pest, Coronaproctus castanopsis (Monophlebidae) has caused serious damage to the globally valuable Gutianshan ecosystem, China. In this study, we assembled the first chromosome-level geno...

Yi-**n Huang, **u-Shuang Zhu, **ao-Nan Chen, **n-Yi Zheng, Bao-Shan Su… in Scientific Data (2024)

Article

Macro CD5L⁺ deteriorates CD8⁺T cells exhaustion and impairs combination of Gemcitabine-Oxaliplatin-Lenvatinib-anti-PD1 therapy in intrahepatic cholangiocarcinoma

Intratumoral immune status influences tumor therapeutic response, but it remains largely unclear how the status determines therapies for patients with intrahepatic cholangiocarcinoma. Here, we examine the sing...

Jia-Cheng Lu, Lei-Lei Wu, Yi-Ning Sun, **ao-Yong Huang, Chao Gao… in Nature Communications (2024)

Article

Establishment of a forward primers-superposed amplification analysis for accurate aspirin pharmacogenomic measurement

Genoty** of gDNA rs12041331 (PEAR1), rs6065 (GP1BA), and rs730012 (LTC4S) can provide systematic guidance on the use of aspirin. However, an accurate, reliable and economical approach to simultaneous detecti...

Chun-Yan Li, ** Yang, Jie Zheng, **g Zhang, Yi-Qing Liu… in Scientific Reports (2024)

Article

Neoadjuvant camrelizumab and apatinib combined with chemotherapy versus chemotherapy alone for locally advanced gastric cancer: a multicenter randomized phase 2 trial

Prospective evidence regarding the combination of programmed cell death (PD)−1 and angiogenesis inhibitors in treating locally advanced gastric cancer (LAGC) is limited. In this multicenter, randomized, phase ...

Jian-**an Lin, Yi-Hui Tang, Hua-Long Zheng, Kai Ye, Jian-Chun Cai… in Nature Communications (2024)

Article

Reassessing endothelial-to-mesenchymal transition in mouse bone marrow: insights from lineage tracing models

Endothelial cells (ECs) and bone marrow stromal cells (BMSCs) play crucial roles in supporting hematopoiesis and hematopoietic regeneration. However, whether ECs are a source of BMSCs remains unclear. Here, we...

Jia Cao, Ling **, Zi-Qi Yan, **ao-Kai Wang, You-You Li, Zun Wang… in Nature Communications (2023)

Article

D-serine reconstitutes synaptic and intrinsic inhibitory control of pyramidal neurons in a neurodevelopmental mouse model for schizophrenia

The hypothesis of N-methyl-D-aspartate receptor (NMDAR) dysfunction for cognitive impairment in schizophrenia constitutes the theoretical basis for the translational application of NMDAR co-agonist D-serine or...

**ao-Qin Zhang, Le Xu, **n-Yi Zhu, Zi-Hang Tang, Yi-Bei Dong… in Nature Communications (2023)

Article

Indocyanine green fluorescence imaging-guided versus conventional laparoscopic lymphadenectomy for gastric cancer: long-term outcomes of a phase 3 randomised clinical trial

Indocyanine green (ICG) fluorescence imaging-guided lymphadenectomy has been demonstrated to be effective in increasing the number of lymph nodes (LNs) retrieved in laparoscopic gastrectomy for gastric cancer ...

Qi-Yue Chen, Qing Zhong, Zhi-Yu Liu, ** Li, Guang-Tan Lin… in Nature Communications (2023)

Article

Analysis of factors of willingness to adopt intelligent construction technology in highway construction enterprises

This study aims to investigate the factors that influence the willingness of highway construction enterprises in China to adopt intelligent construction technology. Based on the existing literature, a TOSE fra...

Zhi-chao Zhou, Yi-kun Su, Zhi-zhe Zheng, Yi-lin Wang in Scientific Reports (2023)

Article

Systematic review and integrated data analysis reveal diverse pangolin-associated microbes with infection potential

There has been increasing global concern about the spillover transmission of pangolin-associated microbes. To assess the risk of these microbes for emergence as human pathogens, we integrated data from multipl...

Run-Ze Ye, **ao-Yang Wang, Yu-Yu Li, Bao-Yu Wang, Ke Song… in Nature Communications (2023)

Article

The liver microenvironment orchestrates FGL1-mediated immune escape and progression of metastatic colorectal cancer

Colorectal cancer (CRC) patients with liver metastases usually obtain less benefit from immunotherapy, and the underlying mechanisms remain understudied. Here, we identify that fibrinogen-like protein 1 (FGL1)...

Jia-Jun Li, **-Hong Wang, Tian Tian, Jia Liu, Yong-Qiang Zheng… in Nature Communications (2023)

Article

Adhesion-regulating molecule 1 (ADRM1) can be a potential biomarker and target for bladder cancer

Adhesion-regulating molecule 1 (ADRM1) has been implicated in tumor development, yet its specific role in bladder cancer (BC) remains undefined. This study aimed to elucidate the function of ADRM1 in BC throug...

Qing-xin Yu, Jiao-chen Wang, Jun-fei Liu, Lu-xia Ye, Yi-qing Guo… in Scientific Reports (2023)

Article

Molecular features and clinical implications of the heterogeneity in Chinese patients with HER2-low breast cancer

The molecular heterogeneity and distinct features of HER2-low breast cancers, particularly in the Chinese population, are not well understood, limiting its precise management in the era of antibody‒drug conjug...

Lei-Jie Dai, Ding Ma, Yu-Zheng Xu, Ming Li, Yu-Wei Li, Yi **ao… in Nature Communications (2023)