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Article
Open AccessUnconventional human CD61 pairing with CD103 promotes TCR signaling and antigen-specific T cell cytotoxicity
Cancer remains one of the leading causes of mortality worldwide, leading to increased interest in utilizing immunotherapy strategies for better cancer treatments. In the past decade, CD103+ T cells have been asso...
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Article
Open AccessEngineered extracellular vesicles carrying let-7a-5p for alleviating inflammation in acute lung injury
Acute lung injury (ALI) is a life-threatening respiratory condition characterized by severe inflammation and lung tissue damage, frequently causing rapid respiratory failure and long-term complications. The mi...
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Article
Open AccessModified early intensive and treat-and-extend regimen of anti-vascular endothelial growth factor for diabetic macular edema in Taiwan
Given the rising prevalence of patients with diabetes and increasing treatment burden for patients with vision-threatening diabetic macular edema (DME), we aimed to explore the efficacy of modified early inten...
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Article
Open AccessAdjuvant chemotherapy in pathological node-negative non-small cell lung cancer
Non–small cell lung cancer (NSCLC) is associated with a poor survival rate, even for patients with early-stage cancer. Identifying patients with pathological N0 NSCLC who may benefit from adjuvant chemotherapy...
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Article
Interplay Between Inflammatory-immune and Interleukin-17 Signalings Plays a Cardinal Role on Liver Ischemia-reperfusion Injury—Synergic Effect of IL-17Ab, Tacrolimus and ADMSCs on Rescuing the Liver Damage
This study tested the hypothesis that inflammatory and interleukin (IL)-17 signalings were essential for acute liver ischemia (1 h)-reperfusion (72 h) injury (IRI) that was effectively ameliorated by adipose-d...
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Article
Open AccessLncRNA SLCO4A1-AS1 suppresses lung cancer progression by sequestering the TOX4-NTSR1 signaling axis
Metastasis is a multistep process involving the migration and invasion of cancer cells and is a hallmark of cancer malignancy. Long non-coding RNAs (lncRNAs) play critical roles in the regulation of metastasis...
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Article
Dual-task multicomponent exercise–cognitive intervention improved cognitive function and functional fitness in older adults
Maintaining cognitive and physical function is essential to healthy aging.
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Article
Open AccessThe outcomes of thoracoscopic decortication between fungal empyema and bacterial empyema
Fungal empyema is an uncommon disease and is associated with a high mortality rate. Surgical intervention is suggested in stage II and III empyema. However, there were no studies that reported the outcomes of ...
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Article
Staphylococcal phosphatidylglycerol antigens activate human T cells via CD1a
Expressed on epidermal Langerhans cells, CD1a presents a range of self-lipid antigens found within the skin; however, the extent to which CD1a presents microbial ligands from bacteria colonizing the skin is un...
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Article
Open AccessCD1a promotes systemic manifestations of skin inflammation
Inflammatory skin conditions are increasingly recognised as being associated with systemic inflammation. The mechanisms connecting the cutaneous and systemic disease are not well understood. CD1a is a virtuall...
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Article
Open AccessTumor cell-derived asymmetric dimethylarginine regulates macrophage functions and polarization
Asymmetric dimethylarginine (ADMA), which is significantly elevated in the plasma of cancer patients, is formed via intracellular recycling of methylated proteins and serves as a precursor for resynthesis of a...
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Article
Open AccessRejuvenated endothelial progenitor cells through overexpression of cellular prion protein effectively salvaged the critical limb ischemia in rats with preexisting chronic kidney disease
This study tested the hypothesis that overexpression of cellular prion protein in endothelial progenitor cells (PrPcOE-EPCs), defined as “rejuvenated EPCs,” was superior to EPCs for salvaging the critical limb is...
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Article
Open AccessDengue virus co-opts innate type 2 pathways to escape early control of viral replication
Mast cell products and high levels of type 2 cytokines are associated with severe dengue disease. Group 2 innate lymphoid cells (ILC2) are type-2 cytokine-producing cells that are activated by epithelial cytok...
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Article
Open AccessIntrarenal arterial administration of human umbilical cord-derived mesenchymal stem cells effectively preserved the residual renal function of diabetic kidney disease in rat
This experimental study was designed as a preclinical study for testing the hypothesis that intrarenal arterial (IRA) transfusion of human umbilical cord-derived mesenchymal stem cells (HUCDMSCs) therapy prese...
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Article
Open AccessPre-existing asthma as a comorbidity does not modify cytokine responses and severity of COVID-19
A significant portion of COVID-19 sufferers have asthma. The impacts of asthma on COVID-19 progression are still unclear but a modifying effect is plausible as respiratory viruses are acknowledged to be an imp...
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Article
Open Access3-year follow-up of half-dose verteporfin photodynamic therapy for central serous chorioretinopathy with OCT-angiography detected choroidal neovascularization
To assess the 3-year outcome of half-dose verteporfin photodynamic therapy (PDT) in central serous chorioretinopathy (CSC) with optical coherence tomography angiography (OCT-A) detected choroidal neovasculariz...
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Chapter and Conference Paper
Multi-head Attention with Hint Mechanisms for Joint Extraction of Entity and Relation
In this paper, we propose a joint extraction model of entity and relation from raw texts without relying on additional NLP features, parameter threshold tuning, or entity-relation templates as previous studies...
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Chapter and Conference Paper
Exploiting Relevant Hyperlinks in Knowledge Base for Entity Linking
In this study, we propose a new model aiming to enhance the quality of entity linking by exploiting highly relevant hyperlinks in knowledge base for entity disambiguation. We find that most existing studies do...
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Article
Broad and strong memory CD4+ and CD8+ T cells induced by SARS-CoV-2 in UK convalescent individuals following COVID-19
The development of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines and therapeutics will depend on understanding viral immunity. We studied T cell memory in 42 patients following recovery...
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Article
Open AccessIncreased expression of secreted frizzled related protein 1 (SFRP1) predicts ampullary adenocarcinoma recurrence
Ampullary adenocarcinoma is a rare gastrointestinal cancer in which WNT signalling dysregulation has been previously reported. Secreted frizzled related protein 1 (SFRP1) is one of the extracellular ligands of...
