3,156 Result(s)
within
Yi**g Yong
Biomedicine
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Article
Open AccessPresentation of human immunodeficiency virus epitopes by chimeric core particles hepatitis B virus
We have constructed a synthetic open reading frame based on amino acid sequences from two conserved regions of the HIV-1 p120 env protein, and from a predicted antigenic region of the p17 gag protein. We have ...
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Open AccessHigh-does nitric oxide induces apoptosis in HL-60 human myeloid leukemia cells
The treatment of human promyeloid leukemia cell line HL-60 cells with nitric oxide (NO) is associated with loss of proliferative apacity and induction of monocytic differentiation. The present results demonstr...
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Open AccessThe S-genomic RNA of Hantaan virus contains only two trinucleotide repeats at its 5' end and the 3' end of S-specific mRNA is truncated and lacks poly-A tail
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Open AccessDifferential expression of proteins related to START checkpoint of the cell cycle in human stomach, lung, cervix and liver cancers
START (restriction) checkpoint in late G1 of the cell cycle is important in the regulation of cell proliferation. Many tumors have shown abnormalities partly in the components such as p53, proliferating cell n...
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Open AccessMutations of CDKN2 (MTS1/p16(INK4A)) and MTS2/p15(INK4B) genes in human stomach, hepatocellular, and cholangio-carcinomas
The CDKN2 (MTS1/p16(INK4A)) and MTS2/p15(INK4B) genes, encoding cyclin dependent kinase inhibitors, were found to be homozygously deleted at high frequency in cell lines from many different types of cancer and...
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Open AccessStructure of human voltage-dependent calcium channel (VDCC) β3 subunit gene
In excitable and endocrine organs, calcium influxes through the voltage-dependent calcium channel (VDCC), composed of four (α1, α2, β, and δ) subunits. Four isoforms of β subunits (β1, β2, β3, β4) are known to...
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Open AccessThe effects of various hormones and growth factors on the growth of human insulin-producing cell line in serum-free medium
An insulin-producing cell line, HE, was derived from immortalized human pancreatic β-cells transformed by SV40 DNA, To make serum free medium specific for the cells, it was necessary to select basal medium, ho...
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Article
Immunization for Ebola virus infection
Infection by Ebola virus causes rapidly progressive, often fatal, symptoms of fever, hemorrhage and hypotension. Previous attempts to elicit protective immunity for this disease have not met with success. We r...
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Open AccessA mechanism of differential expression of GLUT2 in hepatocyte and pancreatic β-cell line
DNase I footprinting assay using liver nuclear extracts revealed six protected regions between nucleotide -600 and +110 and hence named Box I-VI. Upstream promoter element (UPE), a DNA element playing crucial ...
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Open AccessMolecular biological characterization of enterovirus variant isolated from patients with aseptic meningitis
In Korea, there was a big outbreak of aseptic meningitis in 1993. Six clinical isolates of enterovirus were obtained from patients with aseptic meningitis and were identified as echovirus type 9 by seroty** ...
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Open AccessAlterations of CDKN2 (MTS1/p16INK4A) gene in paraffin-embedded tumor tissues of human stomach, lung, cervix and liver cancers
The CDKN2 (MTS1/p16INK4A) gene, encoding cyclin dependent kinase inhibitor, was found to be homozygously deleted at a high frequency in cell lines from many different types of cancer and some primary cancers. ...
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Open AccessCloning of adriamycin-resistant related (arr) gene in an adriamycin-resistant L1210 variant
A partial fragment of novel sequence (arr, adriamycin-resistant related) was previously identified using the differential display (DD)-PCR technique with adriamycin-resistant L1210 variant (L1210AdR), which sh...
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Open AccessCaffeine causes glycerophosphorylcholine accumulation through ryanodine-inhibitable increase of cellular calcium and activation of phospholipase A2 in cultured MDCK cells
Glycerophosphrylocholine (GPC) is a renal medullary compatible organic osmolyte that is derived from choline via phosphatidylcholine, which is catalyzed in part by phospholipase A2 (PLA2) and its degradation b...
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Open AccessIsolation and characterization of brain-specific transglutaminases from rat
The relevance of transglutaminases with neural function and several disorders has been emphasized recently. Especially, many polypeptides associated with neurodegenerative diseases are suggested to be putative...
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Open AccessNucleolus contains signal molecules that constitute membrane-nucleolus linked pathway
Since there have been very few studies on nucleolar signaling, an attempt was made to establish nucleolar signal pathways which link the cell membrane to the nucleolus for the transfer of extracellular signals...
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Open AccessThe effects of oxygen radicals on the activity of nitric oxide synthase and guanylate cyclase
Reactive oxygen species such as superoxides, hydrogen peroxide (H2O2) and hydroxyl radicals have been suggested to be involved in the catalytic action of nitric oxide synthase (NOS) to produce NO from L-argini...
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Open AccessCysteine carboxyl O-methylation of human placental 23 kDa protein
C-Terminal carboxyl methylation of a human placental 23 kDa protein catalyzed by membrane-associated methyltransferase has been investigated. The 23 kDa protein substrate methylated was partially purified by D...
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Open AccessIsolation of rice allergenic cDNA clones from a rice cDNA library by immunoscreening with a polyclonal antibody specific to 16 kD rice allergenic protein
Clinical cases of type-1 hypersensitive reaction to rice (Oryza sativa) have been reported in western countries as well as in Japan. Among rice proteins, 14-16 kD globulin proteins encoded by multiple gene fam...
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Open AccessPurification and characterization of recombinant murine endostatin in E. coli
Endostatin, a carboxyl-terminal fragment of collagen XVIII is known as an anti-angiogenic agent, that specifically inhibits the proliferation of endothelial cell and the growth of several primary tumor. We rep...
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Open AccessIncreased expression of Gαq protein in the heart of streptozotocin-induced diabetic rats
Heart disease is one of the major cause of death in diabetic patients, but the thogenesis of diabetic cardio-myopathy remains unclear. In this experiment, to sess the significance of G protein signaling pathwa...
