439 Result(s)
within
Biomedicine
Health Promotion and Disease Prevention
Oncology
Yi**g Yong
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Article
Cytochrome P450 2E1 polymorphism and nasopharyngeal carcinoma development in Thailand: a correlative study
Nasopharyngeal carcinoma (NPC) is a rare tumor in most parts of the world but occurs at relatively high frequency among people of Chinese descent. The cytochrome P450 2E1 enzyme (CYP2E1) is responsible for the...
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Open AccessRelationship between cyclooxygenase 8473T>Cpolymorphism and the risk of lung cancer: a case-control study
Cyclooxygenase-2 (COX-2) plays an important role in the development of lung cancer. DNA sequence variations in the COX-2 gene may lead to altered COX-2 production and/or activity, and so they cause inter-individu...
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Open AccessPolymorphisms of XRCC1 genes and risk of nasopharyngeal carcinoma in the Cantonese population
Nasopharyngeal carcinoma (NPC) is one of the most common cancers in southern China. In addition to environmental factors such as Epstein-Barr virus infection and diet, genetic susceptibility has been reported ...
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Open AccessTissue microarray analysis reveals a tight correlation between protein expression pattern and progression of esophageal squamous cell carcinoma
The development of esophageal squamous cell carcinoma (ESCC) progresses a multistage process, collectively known as precursor lesions, also called dysplasia (DYS) and carcinoma in situ (CIS), subsequent invasive ...
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Open AccessPolymorphisms in the epidermal growth factor receptor gene and the risk of primary lung cancer: a case-control study
Polymorphisms in Epidermal Growth Factor Receptor (EGFR) gene may influence EGFR production and/or activity, thereby modulating susceptibility to lung cancer. To test this hypothesis, we investigated the associat...
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Open AccessClinicopathologic significance of HIF-1α, p53, and VEGF expression and preoperative serum VEGF level in gastric cancer
Hypoxia influences tumor growth by inducing angiogenesis and genetic alterations. Hypoxia-inducible factor 1α (HIF-1α), p53, and vascular endothelial growth factor (VEGF) are all important factors in the mecha...
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Open AccessEvaluation of high-risk Human papillomaviruses type distribution in cervical cancer in Sichuan province of China
Infection with high-risk human papillomavirus is an important factor associated with cervical cancer, and the distribution of HPV types varies greatly worldwide. Determination of type-specific HPV prevalence c...
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Open AccessEffects of COX-2 inhibition on expression of vascular endothelial growth factor and interleukin-8 in lung cancer cells
Cyclooxygenase (COX)-2 has been implicated in tumour progression, angiogenesis and metastasis in non-small cell lung cancer (NSCLC). We speculated that inhibition of COX-2 activity might reduce expression of t...
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Article
Open AccessIn silico analysis and verification of S100 gene expression in gastric cancer
The S100 protein family comprises 22 members whose protein sequences encompass at least one EF-hand Ca2+ binding motif. They were involved in the regulation of a number of cellular processes such as cell cycle pr...
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Open AccessPrognostic significance of VEGF expression in patients with bulky cervical carcinoma undergoing neoadjuvant chemotherapy
The prediction of response to treatment would be valuable for managing cervical carcinoma with neoadjuvant chemotherapy.
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Open AccessPrognostic parameters for recurrence of papillary thyroid microcarcinoma
Papillary thyroid microcarcinoma (PTMC) is defined as a papillary thyroid carcinoma less than or equal to 1.0 cm in size. Independent prognostic factors for clinical recurrence of PTMC have not been clearly de...
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Open AccessVoluntary exercise inhibits intestinal tumorigenesis in Apc Min/+mice and azoxymethane/dextran sulfate sodium-treated mice
Epidemiological studies suggest that physical activity reduces the risk of colon cancer in humans. Results from animal studies, however, are inconclusive. The present study investigated the effects of voluntar...
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Open AccessmRNA expression of the DNA replication-initiation proteins in epithelial dysplasia and squamous cell carcinoma of the tongue
The tongue squamous cell carcinomas (SCCs) are characterized by high mitotic activity, and early detection is desirable. Overexpression of the DNA replication-initiation proteins has been associated with dyspl...
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Open AccessIdentification of ATP synthase beta subunit (ATPB) on the cell surface as a non-small cell lung cancer (NSCLC) associated antigen
Antibody-based immuneotherapy has achieved some success for cancer. But the main problem is that only a few tumor-associated antigens or therapeutic targets have been known to us so far. It is essential to ide...
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Open AccessClinical significances of preoperative serum interleukin-6 and C-reactive protein level in operable gastric cancer
The interleukin-6 (IL-6) pathway is one of the mechanisms that link inflammation and angiogenesis to malignancy. Because the C-reactive protein (CRP) is a representative marker for inflammation, CRP has recent...
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Article
Open AccessCytoplasmic Kaiso is associated with poor prognosis in non-small cell lung cancer
Kaiso has been identified as a new member of the POZ-zinc finger family of transcription factors that are implicated in development and cancer. Although controversy still exists, Kaiso is supposed to be involv...
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Open AccessLiposarcoma: exploration of clinical prognostic factors for risk based stratification of therapy
Prognosis and optimal treatment strategies of liposarcoma have not been fully defined. The purpose of this study is to define the distinctive clinical features of liposarcomas by assessing prognostic factors.
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Open AccessCarbonic anhydrase 9 is a predictive marker of survival benefit from lower dose of bevacizumab in patients with previously treated metastatic colorectal cancer
Carbonic anhydrase 9 (CA9) is a marker for hypoxia and acidosis, which is linked to a poor prognosis in human tumors. The purpose of this comparative analysis was to evaluate whether CA9 and VEGF expression ar...
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Open AccessXPD codon 312 and 751 polymorphisms, and AFB1 exposure, and hepatocellular carcinoma risk
Genetic polymorphisms in DNA repair genes may influence individual variation in DNA repair capacity, which may be associated with risk of hepatocellular carcinoma (HCC) related to the exposure of aflatoxin B1 ...
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Open AccessExpression of HIF-1alpha and VEGF in colorectal cancer: association with clinical outcomes and prognostic implications
Hypoxia-inducible factor 1 alpha (HIF-1α) and vascular endothelial growth factor (VEGF) are frequently overexpressed in numerous types of cancers and are known to be important regulators of angiogenesis. Until...
