14,990 Result(s)
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Open AccessMolecular circadian clock disruption in the leukocytes of individuals with type 2 diabetes and overweight, and its relationship with leukocyte–endothelial interactions
Alterations in circadian rhythms increase the likelihood of develo** type 2 diabetes and CVD. Circadian rhythms are controlled by several core clock genes, which are expressed in nearly every cell, including...
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Open AccessEfficacy and safety of oral semaglutide monotherapy vs placebo in a predominantly Chinese population with type 2 diabetes (PIONEER 11): a double-blind, Phase IIIa, randomised trial
The aim of this study was to evaluate the efficacy and safety of oral semaglutide monotherapy vs placebo in a predominantly Chinese population with type 2 diabetes insufficiently controlled with diet and exerc...
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Open AccessEfficacy and safety of oral semaglutide vs sitagliptin in a predominantly Chinese population with type 2 diabetes uncontrolled with metformin: PIONEER 12, a double-blind, Phase IIIa, randomised trial
The aim of this study was to assess the efficacy and safety of oral semaglutide vs sitagliptin in a predominantly Chinese population with type 2 diabetes inadequately controlled with metformin treatment.
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Heterotypic macrophages/microglia differentially contribute to retinal ischaemia and neovascularisation
Diabetic retinopathy is characterised by neuroinflammation that drives neuronal and vascular degenerative pathology, which in many individuals can lead to retinal ischaemia and neovascularisation. Infiltrating...
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Open AccessTrajectories of BMI before and after diagnosis of type 2 diabetes in a real-world population
Few studies have examined the clinical characteristics associated with changes in weight before and after diagnosis of type 2 diabetes. Using a large real-world cohort, we derived trajectories of BMI before an...
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Open AccessHigher fibre and lower carbohydrate intake are associated with favourable CGM metrics in a cross-sectional cohort of 470 individuals with type 1 diabetes
The aim of this work was to investigate the association between macronutrient intakes and continuous glucose monitoring (CGM) metrics in individuals with type 1 diabetes.
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Open AccessTechnology advances in diabetes pregnancy: right technology, right person, right time
This review outlines some of the extraordinary recent advances in diabetes technology, which are transforming the management of type 1 diabetes before, during and after pregnancy. It highlights recent improvem...
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Open AccesstRNA-derived fragments in T lymphocyte–beta cell crosstalk and in type 1 diabetes pathogenesis in NOD mice
tRNAs play a central role in protein synthesis. Besides this canonical function, they were recently found to generate non-coding RNA fragments (tRFs) regulating different cellular activities. The aim of this s...
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Open AccessSingle-cell transcriptomic profiling of human pancreatic islets reveals genes responsive to glucose exposure over 24 h
Disruption of pancreatic islet function and glucose homeostasis can lead to the development of sustained hyperglycaemia, beta cell glucotoxicity and subsequently type 2 diabetes. In this study, we explored the...
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Stretching intervention can prevent muscle injuries: a systematic review and meta-analysis
Previous meta-analysis studies concluded that static stretching intervention cannot decrease all-cause injury in healthy active individuals. On the other hand, static stretching intervention may decrease muscl...
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Experience of exercising in a noisy environment disrupts hippocampal biochemical responses to light intensity exercise
The hippocampus is a brain region susceptible to the deleterious effects of stressors. Therefore, it is crucial to comprehend the adverse consequences of various stressors on the hippocampus. Previous studies ...
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Transgender healthcare: metabolic outcomes and cardiovascular risk
Transgender identity is often associated with gender dysphoria and minority stress. Gender-affirming hormone treatment (GAHT) includes masculinising or feminising treatment and is expected to be lifelong in mo...
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The SWI/SNF chromatin remodelling complex regulates pancreatic endocrine cell expansion and differentiation in mice in vivo
Strategies to augment functional beta cell mass include directed differentiation of stem cells towards a beta cell fate, which requires extensive knowledge of transcriptional programs governing endocrine proge...
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Impact of rest interval duration on post-exercise recovery dynamics, ventilatory threshold and respiratory compensation point in endurance athletes: A randomized controlled trial
The primary objective of this study was to investigate the impact of varying rest interval durations in High-Intensity Interval Training (HIIT) on several physiological parameters: Excess Post-Exercise Oxygen ...
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Open AccessTechnology in the management of diabetes in hospitalised adults
Suboptimal glycaemic management in hospitals has been associated with adverse clinical outcomes and increased financial costs to healthcare systems. Despite the availability of guidelines for inpatient glycaem...
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The effect of whole-body vibration with medium and high frequencies in static and dynamic squats on jump performance in healthy non-athlete females
Whole-body vibration (WBV) has been reported to influence performance improvement. However, its effects may vary based on device parameters and body positioning. This study aims to assess the effects of two fr...
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Correction: Separate and combined effects of semaglutide and empagliflozin on kidney oxygenation and perfusion in people with type 2 diabetes: a randomised trial
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Open AccessGestational age at birth and type 1 diabetes in childhood and young adulthood: a nationwide register study in Finland, Norway and Sweden
Children and adults born preterm have an increased risk of type 1 diabetes. However, there is limited information on risk patterns across the full range of gestational ages, especially after extremely preterm ...
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An unclear role for the GLP-1 metabolite GLP-1(9–36) in human islet physiology
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Should children with type 1 diabetes really receive statin treatment using the same criteria as for children with familial hypercholesterolaemia? Reply to Sánchez‑Hernández and Wägner [letter]
