Prevention and Treatment of Atherosclerosis
Improving State-of-the-Art Management and Search for Novel Targets
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Medicine & Public Health
Metabolic Diseases
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Chapter
Correction to: Blood Pressure-Lowering Therapy
The Open Access chapter ‘Blood Pressure-Lowering Therapy’ was published online unfortunately without the Conflict of Interest statement. The COI statement should appear as:
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Chapter
Smooth Muscle Cell-Proteoglycan-Lipoprotein Interactions as Drivers of Atherosclerosis
In humans, smooth muscle cells (SMCs) are the main cell type in the artery medial layer, in pre-atherosclerotic diffuse thickening of the intima, and in all stages of atherosclerotic lesion development. SMCs s...
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Blood Pressure-Lowering Therapy
Extensive evidence demonstrates that lowering blood pressure can substantially reduce the risk of atherosclerotic cardiovascular disease and death.
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Metabolism of Triglyceride-Rich Lipoproteins
Triglycerides are critical lipids as they provide an energy source that is both compact and efficient. Due to its hydrophobic nature triglyceride molecules can pack together densely and so be stored in adipose...
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The Epigenome in Atherosclerosis
Emerging evidence suggests the growing importance of “nongenetic factors” in the pathogenesis of atherosclerotic vascular disease. Indeed, the inherited genome determines only part of the risk profile as genom...
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Diet, Lifestyle, Smoking
Cardiovascular disease is the leading cause of death globally The past few decades have shown that especially low- and middle-income countries have undergone rapid industrialization, urbanization, economic dev...
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High Density Lipoproteins: Is There a Comeback as a Therapeutic Target?
Low plasma levels of High Density Lipoprotein (HDL) cholesterol (HDL-C) are associated with increased risks of atherosclerotic cardiovascular disease (ASCVD). In cell culture and animal models, HDL particles e...
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Antithrombotic Therapy: Prevention and Treatment of Atherosclerosis and Atherothrombosis
Atherosclerosis is a multifactorial vascular disease that develops in the course of a lifetime. Numerous risk factors for atherosclerosis have been identified, mostly inflicting pro-inflammatory effects. Vesse...
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LDL-Cholesterol-Lowering Therapy
The causal relation between elevated levels of LDL-C and cardiovascular disease has been largely established by experimental and clinical studies. Thus, the reduction of LDL-C levels is a major target for the ...
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Anti-inflammatory and Immunomodulatory Therapies in Atherosclerosis
Hypercholesterolemia is a major risk factor in atherosclerosis development and lipid-lowering drugs (i.e., statins) remain the treatment of choice. Despite effective reduction of LDL cholesterol in patients, a...
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Prevention and Treatment of Atherosclerosis: The Use of Nutraceuticals and Functional Foods
Nutritional interventions are effective and – in theory – easy to implement primary and secondary prevention strategies that reduce several risk factors of atherosclerosis and cardiovascular disease (CVD). Yet...
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Novel Adipose Tissue Targets to Prevent and Treat Atherosclerosis
Adipose tissue as a major organ of lipid and lipoprotein metabolism has a major impact on metabolic homeostasis and thus influences the development of atherosclerosis and related cardiometabolic diseases. Unhe...
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Book
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Lipidomics in Biomarker Research
Lipids are natural substances found in all living organisms and involved in many biological functions. Imbalances in the lipid metabolism are linked to various diseases such as obesity, diabetes, or cardiovasc...
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Neutrophil Extracellular Traps in Atherosclerosis and Thrombosis
Despite effective therapeutic and preventive strategies, atherosclerosis and its complications still represent a substantial health burden. Leukocytes and inflammatory mechanisms are increasingly recognized as...
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Nonalcoholic Fatty Liver Disease
Nonalcoholic fatty liver disease (NAFLD) is considered the hepatic manifestation of the metabolic syndrome (MetS) and comprises one of the largest health threats of the twenty-first century. In this chapter, w...
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Regulatory Non-coding RNAs in Atherosclerosis
Regulatory RNAs like microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) control vascular and immune cells’ phenotype and thus play a crucial role in atherosclerosis. Moreover, the mutual interactions betwee...
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Glycaemic Control in Diabetes
Reduction of glucose is the hallmark of diabetes therapy proven to reduce micro- and macro-vascular risk in patients with type 1 diabetes. However glucose-lowering efficacy trials in type 2 diabetes didn’t sho...
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Microbiome and Cardiovascular Disease
Atherosclerotic cardiovascular disease (ASCVD) is a prime example of a systems disease. In the initial phase, apolipoprotein B-containing cholesterol-rich lipoproteins deposit excess cholesterol in macrophage-...
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Genomic Strategies Toward Identification of Novel Therapeutic Targets
Coronary artery disease, myocardial infarction, and secondary damages of the myocardium in the form of ischemic heart disease remain major causes of death in Western countries. Beyond traditional risk factors ...
