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  1. No Access

    Chapter

    Corticotropin-Releasing Factors

    Hypothalamic regulation of pituitary adrenocorticotropic hormone (ACTH) secretion was proposed in 1948 (1) and confirmed in 1955 by the demonstration that a crude extract of the stalk median eminence induced A...

    Lynnette K. Nieman, D. Lynn Loriaux, George P. Chrousos in The Brain as an Endocrine Organ (1989)

  2. No Access

    Chapter

    The Pineal and Its Indole Products: Basic Aspects and Clinical Applications

    After decades of conflicting findings concerning the functions of the pineal, research within the last 20 years has finally begun to unravel the complex interactions of this ubiquitously acting gland. Indeed, ...

    Russel J. Reiter in The Brain as an Endocrine Organ (1989)

  3. No Access

    Chapter

    Feedback Regulation of Growth Hormone Secretion

    Growth hormone (GH) is synthesized, stored, and secreted by the somatotroph cells of the anterior pituitary. These cells are densely granulated, with secretory granules measuring 250–500 nm on electron microsc...

    Shlomo Melmed in The Brain as an Endocrine Organ (1989)

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    Book

    The Brain as an Endocrine Organ

    Margo Panush Cohen M.D., Ph.D.… in Endocrinology and Metabolism (1989)

  5. No Access

    Chapter

    Gonadotropin Releasing Hormones: Physiopathology and Clinical Applications

    In 1971, Schally and associates reported the isolation, identification, and synthesis of gonadotropin releasing hormone (GnRH), also called luteinizing hormone releasing hormone (LHRH) or luteinizing releasing...

    Kamran S. Moghissi in The Brain as an Endocrine Organ (1989)

  6. No Access

    Chapter

    The Neurobiology of Anorexia Nervosa: An Auto-Addiction?

    Anorexia nervosa (AN) is a disorder in which patients refuse to eat, as a result of a morbid fear of obesity. They believe themselves to be “fat and ugly” despite severe emaciation and an appearance shocking t...

    Mary Ann Marrazzi, Elliot D. Luby in The Brain as an Endocrine Organ (1989)

  7. No Access

    Chapter

    Neuropeptides and Glucose Metabolism

    In recent years, numerous new biologically active peptides have been discovered in the gastrointestinal tract. While immunohistochemical evidence suggests that at least 20 of them are present in the brain (1–3...

    Hideo Sasaki, Seijiro Marubashi, Yoshikazu Yawata… in The Brain as an Endocrine Organ (1989)

  8. No Access

    Chapter

    Brain Adenosine and Purinergic Modulation of Central Nervous System Excitability

    Evidence that adenosine can modify a variety of physiologic processes first appeared when Drury and Szent-Gyorgi (1) reported that the administration of adenosine to mammals caused a decrease in arterial blood...

    J. W. Phillis in The Brain as an Endocrine Organ (1989)