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    Article

    Loss of TDP-43 function underlies hippocampal and cortical synaptic deficits in TDP-43 proteinopathies

    TDP-43 proteinopathy is linked to neurodegenerative diseases that feature synaptic loss in the cortex and hippocampus, although it remains unclear how TDP-43 regulates mature synapses. We report that, in adult...

    Jiangxia Ni, Yongfei Ren, Tonghui Su, Jia Zhou, Chaoying Fu, Yi Lu… in Molecular Psychiatry (2023)

  2. Article

    mGluR5 Positive Allosteric Modulators Facilitate both Hippocampal LTP and LTD and Enhance Spatial Learning

    Highly selective positive allosteric modulators (PAMs) of metabotropic glutamate receptor subtype 5 (mGluR5) have emerged as a potential approach to treat positive symptoms associated with schizophrenia. mGluR...

    Jennifer E Ayala, Yelin Chen, Jessica L Banko… in Neuropsychopharmacology (2009)

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