41 Result(s)
within
Yao LI
English
Cell Biology
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Article
Risk haplotype analysis for bovine paratuberculosis
Paratuberculosis (Johne’s disease), caused by Mycobacterium avium subsp. paratuberculosis, is an important disease for bovines, although its genetic basis is poorly understood. In this study, three candidate gene...
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Chapter and Conference Paper
A Model for Human Postural Regulation
We present a computational model of a quietly standing human. The model is composed of a system of 3 rigid links. There are two joints, one at the ankle and one at the hip. This is consistent with considerable...
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Article
Open AccessAchievements and challenges in bioartificial kidney development
Bioartificial kidneys (BAKs) combine a conventional hemofilter in series with a bioreactor unit containing renal epithelial cells. The epithelial cells derived from the renal tubule should provide transport, m...
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Article
A new hope for patients suffering from multiple myeloma
Multiple myeloma is a common hematological malignancy that leads to the occurrence of bone lesions. The combination of traditional cytotoxic and novel agents is usually taken to treat multiple myeloma-related ...
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Article
Open Access17beta-estradiol promotes the odonto/osteogenic differentiation of stem cells from apical papilla via mitogen-activated protein kinase pathway
Estrogen plays an important role in the osteogenic differentiation of mesenchymal stem cells, while stem cells from apical papilla (SCAP) can contribute to the formation of dentin/bone-like tissues. To date, t...
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Article
The Expression of CAP1 After Traumatic Brain Injury and Its Role in Astrocyte Proliferation
Adenylate cyclase-associated protein 1 (CAP1), a member of cyclase-associated proteins involved in the regulation of actin filaments, was recently reported to play a role in the pathology of sciatic nerves inj...
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Protocol
Skin Biopsy and Patient-Specific Stem Cell Lines
The generation of patient-specific induced pluripotent stem (iPS) cells permits the development of next-generation patient-specific systems biology models reflecting personalized genomics profiles to better un...
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Article
Open AccessNeuroretinal hypoxic signaling in a new preclinical murine model for proliferative diabetic retinopathy
Diabetic retinopathy (DR) affects approximately one-third of diabetic patients and, if left untreated, progresses to proliferative DR (PDR) with associated vitreous hemorrhage, retinal detachment, iris neovasc...
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Article
Two new species of the genus Streptomyces: Streptomyces camponoti sp. nov. and Streptomyces cuticulae sp. nov. isolated from the cuticle of Camponotus japonicus Mayr
Two novel actinomycetes, designated strains 2C-SSA16(2)T and 1C-GS8T, were isolated from the cuticle of Camponotus japonicus Mayr, collected from Northeast Agricultural University, Heilongjiang Province, north Ch...
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Article
Open AccessiASPP–PP1 complex is required for cytokinetic abscission by controlling CEP55 dephosphorylation
Cytokinesis is the last step of cell division and is concluded by the abscission of the intercellular bridge that connects two daughter cells. The tight regulation of cytokinesis completion is essential becaus...
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Article
Interleukin-1 Receptor Associated Kinase 1 Mediates the Maintenance of Neuropathic Pain after Chronic Constriction Injury in Rats
Neuropathic pain (NP) has complicated pathogenesis as it mainly involves a lesion or dysfunction of the somatosensory nervous system and its clinical treatment remains challenging. Chronic constriction injury ...
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Article
Open AccessIFITM3 promotes bone metastasis of prostate cancer cells by mediating activation of the TGF-β signaling pathway
Advanced-stage prostate cancer (PCa) is often diagnosed with bone metastasis, for which there are limited therapies. Transforming growth factor β (TGF-β) is known to induce epithelial–mesenchymal transition (E...
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Article
Open AccessReciprocal regulation of miR-1205 and E2F1 modulates progression of laryngeal squamous cell carcinoma
The burgeoning functions of many microRNAs (miRs) have been well study in cancer. However, the level and function of miR-1205 in laryngeal squamous cell cancer remains unknown. In the current research, we vali...
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Article
Open AccessCrosstalk between androgen and Wnt/β-catenin leads to changes of wool density in FGF5-knockout sheep
Fibroblast growth factor 5 (FGF5) is a famous dominant inhibitor of anagen phase of hair cycle. Mutations of FGF5 gene result in a longer wool in mice, donkeys, dogs, cats, and even in human eyelashes. Sheep is a...
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Article
Open AccessStabilization of HIF-1α alleviates osteoarthritis via enhancing mitophagy
Mitochondrial dysfunction leads to osteoarthritis (OA) and disc degeneration. Hypoxia inducible factor-1α (HIF-1α) mediated mitophagy has a protective role in several diseases. However, the underlying mechanis...
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Article
Open AccessN6-methyladenine is incorporated into mammalian genome by DNA polymerase
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Article
Open AccessAHA1 upregulates IDH1 and metabolic activity to promote growth and metastasis and predicts prognosis in osteosarcoma
Osteosarcoma (OS) is the most common primary malignant bone tumor in children and adolescents. Although activator of HSP90 ATPase activity 1 (AHA1) is reported to be a potential oncogene, its role in osteosarc...
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Article
Author Correction: N6-methyladenine is incorporated into mammalian genome by DNA polymerase
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Article
Molecular basis for ubiquitin ligase CRL2FEM1C-mediated recognition of C-degron
Proteome integrity depends on the ubiquitin–proteasome system to degrade unwanted or abnormal proteins. In addition to the N-degrons, C-terminal residues of proteins can also serve as degradation signals (C-de...
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Article
Elevating sestrin2 attenuates endoplasmic reticulum stress and improves functional recovery through autophagy activation after spinal cord injury
Spinal cord injury (SCI) is a devastating neurological trauma that causes losses of motor and sensory function. Sestrin2, also known as hypoxia inducible gene 95, is emerging as a critical determinant of cell ...
