75 Result(s)
within
Yao LI
Life Sciences
English
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Article
ExploringMycobacterium tuberculosis infection-induced alterations in gene expression in macrophage by microarray hybridization
Tuberculosis remains a serious threat to public health. Its causative agentMycobacterium tuberculosis is an intracellular pathogen which survives and replicates within cells of the host immune system, primarily m...
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Article
cDNA cloning and expression analysis of a novel human F-box domain containing gene†
F-box proteins are a large family of eukaryotic proteins that are characterized by an approximately 40 amino acid motif. Some F-box proteins are critical for the controlled degradation of cellular regulatory p...
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Article
Characterization of a cDNA encoding a protein with limited similarity to β1, 3-N-acetylglucosaminyltransferase
Glycosyltransferases constitute a large group of enzymes that are involved in a wide range of functions in all living organisms. By large–scale sequencing analysis of a human fetal brain cDNA library, we isola...
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Article
Risk haplotype analysis for bovine paratuberculosis
Paratuberculosis (Johne’s disease), caused by Mycobacterium avium subsp. paratuberculosis, is an important disease for bovines, although its genetic basis is poorly understood. In this study, three candidate gene...
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Article
Open AccessGlobal gene expression analysis reveals reduced abundance of putative microRNA targets in human prostate tumours
Recently, microRNAs (miRNAs) have taken centre stage in the field of human molecular oncology. Several studies have shown that miRNA profiling analyses offer new possibilities in cancer classification, diagnos...
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Article
Transgene expression of enhanced green fluorescent protein in cloned rabbits generated from in vitro-transfected adult fibroblasts
Live rabbits have previously been generated through nuclear transfer using adult cells as nuclear donors. We demonstrated in this study that transfected adult rabbit fibroblasts are also capable of supporting ...
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Article
Open AccessA stochastic model for identifying differential gene pair co-expression patterns in prostate cancer progression
The identification of gene differential co-expression patterns between cancer stages is a newly develo** method to reveal the underlying molecular mechanisms of carcinogenesis. Most researches of this subjec...
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Open AccessModeling genetic imprinting effects of DNA sequences with multilocus polymorphism data
Single nucleotide polymorphisms (SNPs) represent the most widespread type of DNA sequence variation in the human genome and they have recently emerged as valuable genetic markers for revealing the genetic arch...
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Open AccessFunctional map** of reaction norms to multiple environmental signals through nonparametric covariance estimation
The identification of genes or quantitative trait loci that are expressed in response to different environmental factors such as temperature and light, through functional map**, critically relies on precise ...
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Article
A global genomic view on LNX siRNA-mediated cell cycle arrest
LNX protein is the first described PDZ domain-containing member of the RING finger-type E3 ubiquitin ligase family. Studies have approved that LNX could participate in signal transduction, such as Notch pathwa...
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Article
Inhibition of p53-p21 pathway promotes the differentiation of rat bone marrow mesenchymal stem cells into cardiomyocytes
P53 is shown recently to play an important role in the proliferation and differentiation of bone marrow mesenchymal stem cells (BMMSCs). In this study, by inhibiting p53-p21 pathway with p53 inhibitor (p-fifty...
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Article
A model for linkage analysis with apomixis
Apomixis, or asexual reproduction through seeds, occurs in over 400 species of angiosperms. Although apomixis can favorably perpetuate desired genotypes through successive seed generation, it may also bring ab...
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Article
Open AccessSystems map** of HIV-1 infection
Mathematical models of viral dynamics in vivo provide incredible insights into the mechanisms for the nonlinear interaction between virus and host cell populations, the dynamics of viral drug resistance, and the ...
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MicroRNA-185 suppresses proliferation, invasion, migration, and tumorigenicity of human prostate cancer cells through targeting androgen receptor
Previous studies have shown that androgen receptor (AR) is involved in the progression of prostate cancer (CaP) by several mechanisms. However, how AR is regulated has not been fully understood. In this study,...
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Article
A genome-wide analysis of multidrug-resistant and extensively drug-resistant strains of Mycobacterium tuberculosis Bei**g genotype
The Bei**g genotype of Mycobacterium tuberculosis (MTB) is one of the most successful MTB lineages that has disseminated in the world. In China, the rate of multidrug-resistant (MDR) tuberculosis is significantl...
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Article
A new hope for patients suffering from multiple myeloma
Multiple myeloma is a common hematological malignancy that leads to the occurrence of bone lesions. The combination of traditional cytotoxic and novel agents is usually taken to treat multiple myeloma-related ...
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Article
Molecular characterization of multidrug-resistant Mycobacterium tuberculosis isolated from South-central in China
Rifampicin (RIF) and isoniazid (INH) Mycobacterium tuberculosis isolates were characterized from South-central China and transmission patterns within the Bei**g genotype were detected in multidrug-resistant isol...
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Article
Inheritance of mefenoxam resistance in Phytophthora nicotianae populations from a plant nursery
Three sexual crosses involving isolates of P. nicotianae with differing sensitivity to mefenoxam were established to study the inheritance of mefenoxam resistance. Mefenoxam sensitivity was determined by measurin...
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Article
Open Access17beta-estradiol promotes the odonto/osteogenic differentiation of stem cells from apical papilla via mitogen-activated protein kinase pathway
Estrogen plays an important role in the osteogenic differentiation of mesenchymal stem cells, while stem cells from apical papilla (SCAP) can contribute to the formation of dentin/bone-like tissues. To date, t...
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Open AccessSupervised prediction of drug-induced nephrotoxicity based on interleukin-6 and -8 expression levels
Drug-induced nephrotoxicity causes acute kidney injury and chronic kidney diseases, and is a major reason for late-stage failures in the clinical trials of new drugs. Therefore, early, pre-clinical prediction ...
