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  1. No Access

    Article

    Combination of temperature shift and hydrolysate addition regulates anti-IgE monoclonal antibody charge heterogeneity in Chinese hamster ovary cell fed-batch culture

    Charge heterogeneity has been broadly studied as a critical quality attribute during monoclonal antibody (mAb) production that may subsequently affect product stability and biopotency. However, the charge vari...

    Chen Zheng, Chao Zhuang, **yan Qin, Yantian Chen, Qiang Fu, Hui Qian… in Cytotechnology (2018)

  2. No Access

    Article

    Different fermentation processes produced variants of an anti-CD52 monoclonal antibody that have divergent in vitro and in vivo characteristics

    The anti-CD52 antibody has already been approved for the treatment of patients with resistant chronic lymphocytic leukemia, relapsing-remitting multiple sclerosis, and has demonstrable efficacy against stem ce...

    Chao Zhuang, Chen Zheng, Yantian Chen… in Applied Microbiology and Biotechnology (2017)

  3. No Access

    Article

    Salt ions and related parameters affect PEI–DNA particle size and transfection efficiency in Chinese hamster ovary cells

    Transfection efficiency is directly associated with the expression level and quantity of recombinant protein after the transient transfection of animal cells. The transfection process can be influenced by many...

    Yunxia Sang, Kui **e, Yubin Mu, Yun Lei, Baohong Zhang, Sheng **ong… in Cytotechnology (2015)

  4. No Access

    Article

    Various seeding methods for tissue development of human umbilical-cord-derived mesenchymal stem cells in 3-dimensional PET matrix

    Mesenchymal stem cells derived from human umbilical cords (hUCMSCs) are attractive as a new cell source for tissue engineering. It is essential to investigate and optimize the seeding process of these cells fo...

    Weiwei Li, Min Li, Yantian Chen, Shaoming Zhang… in Biotechnology and Bioprocess Engineering (2014)

  5. No Access

    Article

    Study of differential effects of TGF-beta3/BMP2 on chondrogenesis in MSC cells by gene microarray data analysis

    In order to explore the differential effects of TGF-beta3 and BMP2 on chondrogenesis in mesenchymal stem cells (MSCs), the gene expression profiles of MSC treated with TGF-beta3 and BMP2 were subjected to syst...

    Yunxia Sang, Weidong Zang, Yan Yan, Yong Liu… in Molecular and Cellular Biochemistry (2014)