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  1. Article

    Open Access

    p53 promotes peroxisomal fatty acid β-oxidation to repress purine biosynthesis and mediate tumor suppression

    The metabolic pathways through which p53 functions as a potent tumor suppressor are incompletely understood. Here we report that, by associating with the Vitamin D receptor (VDR), p53 induces numerous genes en...

    Jianhong Zhao, **aojun Zhou, Baoxiang Chen, Mingzhu Lu, Genxin Wang… in Cell Death & Disease (2023)

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    Article

    IL-22 Up-Regulates β-Defensin-2 Expression in Human Alveolar Epithelium via STAT3 but Not NF-κB Signaling Pathway

    Human β-defensin-2(HBD-2) is one of the two major vertebrate antimicrobial peptide families (α and β), which is highly expressed by proinflammatory induction in the lung and exhibit broad-spectrum antimicrobia...

    Amin Li, Yuying Gan, Ruikai Wang, Yanliang Liu, Ting Ma, Mao Huang… in Inflammation (2015)

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    Article

    Paeoniflorin Upregulates β-Defensin-2 Expression in Human Bronchial Epithelial Cell Through the p38 MAPK, ERK, and NF-κB Signaling Pathways

    Paeoniflorin (PF) is one of the principal components of peony, a plant widely used in traditional Chinese medicine for its anti-inflammatory and immunomodulatory effects. Human β-defensin-2 (hBD-2) is an antim...

    Yuying Gan, Xuefan Cui, Ting Ma, Yanliang Liu, Amin Li, Mao Huang in Inflammation (2014)