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Article

MDM2 inhibitor APG-115 exerts potent antitumor activity and synergizes with standard-of-care agents in preclinical acute myeloid leukemia models

Acute myeloid leukemia (AML) is a clinically and genetically heterogeneous clonal disease associated with unmet medical needs. Paralleling the pathology of other cancers, AML tumorigenesis and propagation can ...

Douglas D. Fang, Qiuqiong Tang, Yanhui Kong, Tao Rong, Qixin Wang… in Cell Death Discovery (2021)