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    Article

    The Involvement of the CD40-CD40L Pathway in Activated Platelet-Induced Changes in HUVEC COX-2 and PPARα Expression

    We aim to determine the extent of the CD40-CD40L pathway involvement in activated platelet-induced changes in human umbilical endothelial cells (HUVECs). Activated platelets were co-incubated with HUVECs in th...

    Yan-qing Wu, **ao-shu Chen, Jun-bing Chai in Inflammation (2012)

  2. Article

    Open Access

    Collagen triple helix repeat containing-1 negatively regulated by microRNA-30c promotes cell proliferation and metastasis and indicates poor prognosis in breast cancer

    Collagen triple helix repeat containing-1 (CTHRC1), which was firstly identified overexpressed in the adventitia and neointima of injured rat arteries, could inhibit collagen expression and increase cell migra...

    Yuan-hui Lai, Jian Chen, ** Wang in Journal of Experimental & Clinical Cancer … (2017)

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    Article

    DL-3-n-butylphthalide ameliorates diabetes-associated cognitive decline by enhancing PI3K/Akt signaling and suppressing oxidative stress

    DL-3-n-Butylphthalide (DL-NBP), a small molecular compound extracted from the seeds of Apium graveolens Linn (Chinese celery), has been shown to exert neuroprotective effects due to its anti-inflammatory, anti-ox...

    Bei-ni Wang, Cheng-biao Wu, Zi-miao Chen, Pei-pei Zheng in Acta Pharmacologica Sinica (2021)

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    Article

    Metformin promotes microglial cells to facilitate myelin debris clearance and accelerate nerve repairment after spinal cord injury

    Spinal cord injury (SCI) is one kind of severe trauma for central nervous system. Myelin debris clearance and axon regeneration are essential for nerve regeneration after SCI. Metformin, a glucose-lowering dru...

    Yan-qing Wu, Jun **ong, Zi-li He, Yuan Yuan, Bei-ni Wang in Acta Pharmacologica Sinica (2022)