1,186 Result(s)
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Three distinct signalling responses by murine fibroblasts to genotoxic stress
GENOTOXIC stress triggers signalling pathways that mediate either the protection or killing of affected cells. Whereas induction of p53 involves events in the cell nucleus1, the activation of transcription factor...
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The DNA sequence of the human X chromosome
The human X chromosome has a unique biology that was shaped by its evolution as the sex chromosome shared by males and females. We have determined 99.3% of the euchromatic sequence of the X chromosome. Our ana...
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The finished DNA sequence of human chromosome 12
Nature's series of papers on the finished sequences of human chromosomes continues with the analysis of chromosome 12, representing 4.5 of the genome. It hosts a number of genes mutated in specific cancers, movem...
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The DNA sequence, annotation and analysis of human chromosome 3
After the completion of a draft human genome sequence1, the International Human Genome Sequencing Consortium has proceeded to finish2 and annotate each of the 24 chromosomes comprising the human genome. Here we d...
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The structural basis for activation of plant immunity by bacterial effector protein AvrPto
Many microbial plant pathogens have evolved effector proteins that enhance virulence by neutralizing host-plant defences. Plants have countered by develo** highly specific resistance proteins that recognize ...
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Open AccessThe draft genome of the transgenic tropical fruit tree papaya (Carica papaya Linnaeus)
In the early 1990s an outbreak of papaya ringspot virus (PRSV) in the papaya groves in the Puna district of Hawaii caused severe damage to an important crop. Since then, the planting of two transgenic cultivar...
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Open AccessThe sequence and de novo assembly of the giant panda genome
Using next-generation sequencing technology alone, we have successfully generated and assembled a draft sequence of the giant panda genome. The assembled contigs (2.25 gigabases (Gb)) cover approximately 94% o...
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Erratum: The sequence and de novo assembly of the giant panda genome
Nature 463, 311–317 (2010) In this Article, the Latin species name of the giant panda was written incorrectly as Ailuropoda melanoleura. The correct name is Ailuropoda melanoleuca.
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Open AccessObservation and electric current control of a local spin in a single-molecule magnet
In molecular spintronics, the spin state of a molecule may be switched on and off by changing the molecular structure. Here, we switch on and off the molecular spin of a double-decker bis(phthalocyaninato)terb...
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Molecular regulation of sexual preference revealed by genetic studies of 5-HT in the brains of male mice
To whom should a male direct his efforts to find a mate? Little is known about the mechanisms controlling this fundamental social interaction in mammals. Now it is reported that serotonergic neuron signalling ...
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Open AccessSouth China Sea hydrological changes and Pacific Walker Circulation variations over the last millennium
The relative importance of north–south migrations of the intertropical convergence zone (ITCZ) versus El Niño-Southern Oscillation and its associated Pacific Walker Circulation (PWC) variability for past hydro...
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Latent TGF-β binding protein 3 identifies a second heart field in zebrafish
Progenitor cells from the second heart field, which generate the right ventricle, were considered unique to higher vertebrates with four-chambered hearts. Researchers have now identified a group of cardiac pro...
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Superconductivity at 5 K in alkali-metal-doped phenanthrene
Organic superconductors have π-molecular orbitals, from which electrons can become delocalized, giving rise to metallic conductivity due to orbital overlap between adjacent molecules. Here we report the discovery...
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Open AccessCMOS-based carbon nanotube pass-transistor logic integrated circuits
Field-effect transistors based on carbon nanotubes have been shown to be faster and less energy consuming than their silicon counterparts. However, ensuring these advantages are maintained for integrated circu...
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Broadband graphene terahertz modulators enabled by intraband transitions
Terahertz technology promises myriad applications including imaging, spectroscopy and communications. However, one major bottleneck at present for advancing this field is the lack of efficient devices to manip...
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Open AccessGraphene quilts for thermal management of high-power GaN transistors
Self-heating is a severe problem for high-power gallium nitride (GaN) electronic and optoelectronic devices. Various thermal management solutions, for example, flip-chip bonding or composite substrates, have b...
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Open AccessExcellent capability in degrading azo dyes by MgZn-based metallic glass powders
The lack of new functional applications for metallic glasses hampers further development of these fascinating materials. In this letter, we report for the first time that the MgZn-based metallic glass powders ...
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SUMO1 modification of PTEN regulates tumorigenesis by controlling its association with the plasma membrane
The membrane association of the tumour suppressor phosphatase and tensin homologue (PTEN) is required to oppose the phosphatidylinositol-3-kinase/AKT pathway by dephosphorylation of phosphatidylinositol-3,4,5-...
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Quantum teleportation and entanglement distribution over 100-kilometre free-space channels
Quantum teleportation of independent qubits and entanglement distribution have been demonstrated over free-space channels of about 100 kilometres, representing an important step towards a global quantum network.
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Open AccessThe oyster genome reveals stress adaptation and complexity of shell formation
The Pacific oyster Crassostrea gigas belongs to one of the most species-rich but genomically poorly explored phyla, the Mollusca. Here we report the sequencing and assembly of the oyster genome using short reads ...
