43 Result(s)

Article

Canagliflozin alleviates pulmonary hypertension by activating PPARγ and inhibiting its S225 phosphorylation

Pulmonary hypertension (PH) is a progressive fatal disease with no cure. Canagliflozin (CANA), a novel medication for diabetes, has been found to have remarkable cardiovascular benefits. However, few studies h...

**u-chun Li, **a-yan Zhu, Yang-yue Wang, Shuo-lan Tong… in Acta Pharmacologica Sinica (2024)

Article

Clinical efficacy and safety of tigecycline based on therapeutic drug monitoring for carbapenem-resistant Gram-negative bacterium pneumonia in intensive care units

We investigated the associations between the different doses of tigecycline, its efficacy and safety, and the role of tigecycline therapeutic drug monitoring for patients in the intensive care unit.

**ang-rong Bai, Zhi-zhou Wang, Wen-chao Li, Yan-gai Wang… in BMC Infectious Diseases (2023)

Article

Fungal diversity notes 1512–1610: taxonomic and phylogenetic contributions on genera and species of fungal taxa

This article is the 14th in the Fungal Diversity Notes series, wherein we report 98 taxa distributed in two phyla, seven classes, 26 orders and 50 families which are described and illustrated. Taxa in this stu...

Ruvishika S. Jayawardena, Kevin D. Hyde, Song Wang, Ya-Ru Sun… in Fungal Diversity (2022)

Article

Evaluation of droplet digital PCR rapid detection method and precise diagnosis and treatment for suspected sepsis (PROGRESS): a study protocol for a multi-center pragmatic randomized controlled trial

Sepsis is still a major public health concern and a medical emergency due to its high morbidity and mortality. Accurate and timely etiology diagnosis is crucial for sepsis management. As an emerging rapid and ...

Yuanhan Zhao, Ke Lin, Haocheng Zhang, Guanmin Yuan… in BMC Infectious Diseases (2022)

Article

Pharmacodynamic, pharmacokinetic, and phase 1a study of bisthianostat, a novel histone deacetylase inhibitor, for the treatment of relapsed or refractory multiple myeloma

HDAC inhibitors (HDACis) have been intensively studied for their roles and potential as drug targets in T-cell lymphomas and other hematologic malignancies. Bisthianostat is a novel bisthiazole-based pan-HDACi...

Yu-bo Zhou, Yang-ming Zhang, Hong-hui Huang, Li-**g Shen… in Acta Pharmacologica Sinica (2022)

Article

Geographic distribution of the cagA, vacA, iceA, oipA and dupA genes of Helicobacter pylori strains isolated in China

There are geographic variations in the genotypes of Helicobacter pylori (H. pylori) cagA, vacA, iceA, oipA and dupA. The aim of the study was to investigate the distribution of these genotypes among H. pylori str...

Zhi**g Xue, Hong Yang, Dongxing Su, **angfeng Song, **n Deng… in Gut Pathogens (2021)

Article

SARS-CoV-2 membrane glycoprotein M antagonizes the MAVS-mediated innate antiviral response

A novel SARS-related coronavirus (SARS-CoV-2) has recently emerged as a serious pathogen that causes high morbidity and substantial mortality. However, the mechanisms by which SARS-CoV-2 evades host immunity r...

Yu-Zhi Fu, Su-Yun Wang, Zhou-Qin Zheng, Yi Huang… in Cellular & Molecular Immunology (2021)

Article

Anti-SARS-CoV-2 activities in vitro of Shuanghuanglian preparations and bioactive ingredients

Human infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus disease 2019 (COVID-19) and there is no cure currently. The 3CL protease (3CLpro) is a highly conserved prot...

Hai-xia Su, Sheng Yao, Wen-feng Zhao, Min-jun Li, Jia Liu… in Acta Pharmacologica Sinica (2020)

Article

Freshwater Sordariomycetes

Sordariomycetes is one of the largest classes of Ascomycota that comprises a highly diverse range of fungi mainly characterized by perithecial ascomata and inoperculate unitunicate asci. Freshwater Sordariomyc...

Zong-Long Luo, Kevin D. Hyde, Jian-Kui (Jack) Liu… in Fungal Diversity (2019)

Article

SOMCL-085, a novel multi-targeted FGFR inhibitor, displays potent anticancer activity in FGFR-addicted human cancer models

Aberrant fibroblast growth factor receptor (FGFR) activation is found across a diverse spectrum of malignancies, especially those lacking effective treatments. SOMCL-085 is a novel FGFR-dominant multi-target k...

**-fei Jiang, Yang Dai, **a Peng, Yan-yan Shen, Yi Su… in Acta Pharmacologica Sinica (2018)

Article

Triptolide induces Sertoli cell apoptosis in mice via ROS/JNK-dependent activation of the mitochondrial pathway and inhibition of Nrf2-mediated antioxidant response

Triptolide (TP), an oxygenated diterpene, has a variety of beneficial pharmacodynamic activities but its clinical applications are restricted due to severe testicular injury. This study aimed to delineate the ...

Yu Wang, Su-han Guo, Xue-jun Shang, Li-sha Yu, Jian-wei Zhu… in Acta Pharmacologica Sinica (2018)

Article

Pterostilbene suppresses human endometrial cancer cells in vitro by down-regulating miR-663b

Resveratrol has long been known as an antioxidant and a chemopreventive agent. Similar to resveratrol, pterostilbene (PT) is also a phenolic compound extracted from the Vitis species. However, there are few st...

Ya-ling Wang, Yuan Shen, Jian-** Xu, Kun Han, Yan Zhou… in Acta Pharmacologica Sinica (2017)

Article

Combining 53BP1 with BRCA1 as a biomarker to predict the sensitivity of poly(ADP-ribose) polymerase (PARP) inhibitors

Over half of patients with BRCA1-deficient cancers do not respond to treatment with poly(ADP-ribose) polymerase (PARP) inhibitors. In this study, we report that a combination of 53BP1 and BRCA1 may serve as a ...

Zhong-min Yang, Xue-mei Liao, Yi Chen, Yan-yan Shen… in Acta Pharmacologica Sinica (2017)

Article

Marine-derived chromopeptide A, a novel class I HDAC inhibitor, suppresses human prostate cancer cell proliferation and migration

Histone deacetylases (HDACs), especially HDAC1, 2, 3 and 4, are abundantly expressed and over-activated in prostate cancer that is correlated with the poor prognosis. Thus, inhibition of HDAC activity has emer...

**g-ya Sun, Ji-dong Wang, **n Wang, Hong-chun Liu… in Acta Pharmacologica Sinica (2017)

Article

BX-795 inhibits HSV-1 and HSV-2 replication by blocking the JNK/p38 pathways without interfering with PDK1 activity in host cells

BX-795 is an inhibitor of 3-phosphoinositide-dependent kinase 1 (PDK1), but also a potent inhibitor of the IKK-related kinase, TANKbinding kinase 1 (TBK1) and IKKɛ. In this study we attempted to elucidate the ...

Ai-rong Su, Min Qiu, Yan-lei Li, Wen-tao Xu, Si-wei Song… in Acta Pharmacologica Sinica (2017)

Article

Abstracts from the 8th International Congress of the Asia Pacific Society of Infection Control (APSIC)

Nantanit Sutthiruk, Mari Botti… in Antimicrobial Resistance & Infection Contr… (2017)

Article

Y-QA31, a novel dopamine D₃ receptor antagonist, exhibits antipsychotic-like properties in preclinical animal models of schizophrenia

To investigate the potential effects of Y-QA31, a novel dopamine D₃ receptor antagonist, as an antipsychotic drug.

Xue Sun, Hong-yan Gou, Fei Li, Guan-yi Lu, Rui Song… in Acta Pharmacologica Sinica (2016)

Article

Genetic variants of CDH13 determine the susceptibility to chronic obstructive pulmonary disease in a Chinese population

Adiponectin has been implicated in the development of chronic obstructive pulmonary disease (COPD). The CDH13 gene encodes T-cadherin that is an adiponectin receptor, and genetic variants of CDH13 determine blood...

Yi-ming Yuan, **-long Zhang, Si-cheng Xu, Ren-song Ye… in Acta Pharmacologica Sinica (2016)

Article

Prevalence and mortality of cancer among HIV-infected inpatients in Bei**g, China

Cancer is responsible for elevated HIV-related morbidity and mortality. Research on HIV-infected patients with concurrent cancer is rare in China. The purpose of our study was to investigate the prevalence and...

Jun Yang, Shu Su, Hongxin Zhao, Dennis Wang, Jiali Wang… in BMC Infectious Diseases (2016)

Article

The roles of macrophage autophagy in atherosclerosis

Although various types of drugs and therapies are available to treat atherosclerosis, it remains a major cause of mortality throughout the world. Macrophages are the major source of foam cells, which are hallm...

Bo-zong Shao, Bin-ze Han, Yan-xia Zeng, Ding-feng Su… in Acta Pharmacologica Sinica (2016)