85 Result(s)
within
Yan He-**
Life Sciences, general
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Article
Pretraining a foundation model for generalizable fluorescence microscopy-based image restoration
Fluorescence microscopy-based image restoration has received widespread attention in the life sciences and has led to significant progress, benefiting from deep learning technology. However, most current task-...
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Article
Multi-Frame Cross-Channel Attention and Speaker Diarization Based Speaker-Attributed Automatic Speech Recognition System for Multi-Channel Multi-Party Meeting Transcription
This paper describes a speaker-attributed automatic speech recognition (SA-ASR) system submitted to the multi-channel multi-party meeting transcription challenge, which aims to address the “who spoke what” pro...
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Article
Age-related noncanonical TRMT6–TRMT61A signaling impairs hematopoietic stem cells
Aged hematopoietic stem cells (HSCs) exhibit compromised reconstitution capacity and differentiation bias toward myeloid lineages. However, the molecular mechanism behind HSC aging remains largely unknown. In ...
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Article
Open AccessDifferentiated genomic footprints suggest isolation and long-distance migration of Hmong-Mien populations
The underrepresentation of Hmong-Mien (HM) people in Asian genomic studies has hindered our comprehensive understanding of the full landscape of their evolutionary history and complex trait architecture. South...
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Article
Phenylalanine diminishes M1 macrophage inflammation
Emerging evidence suggests that amino acids dictate the effector functions of immune cells; however, whether and how phenylalanine (Phe) orchestrates the polarization of macrophages is not understood. Here, we...
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Article
Open AccessAssociation between oral microbial dysbiosis and poor functional outcomes in stroke-associated pneumonia patients
Despite advances in our understanding of the critical role of the microbiota in stroke patients, the oral microbiome has rarely been reported to be associated with stroke-associated pneumonia (SAP). We sought ...
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Article
Open AccessThe complete and fully-phased diploid genome of a male Han Chinese
Since the release of the complete human genome, the priority of human genomic study has now been shifting towards closing gaps in ethnic diversity. Here, we present a fully phased and well-annotated diploid hu...
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Article
Enhanced Tribological Performance of Diamond Films by Utilizing DLC and DLC-H Top Layers
High-performance diamond films are highly demanded on tool surfaces for wire-drawing and mechanical sealing applications. Herein, this work aims at enhancing the tribological performance of chemical vapor depo...
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Article
AIWW: a new nutrition-screening tool for the oncologic population
Malnutrition is a common comorbidity among patients with cancer. However, no nutrition-screening tool has been recognized in this population. A quick and easy screening tool for nutrition with high sensitivity...
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Article
Biomarkers of aging
Aging biomarkers are a combination of biological parameters to (i) assess age-related changes, (ii) track the physiological aging process, and (iii) predict the transition into a pathological status. Although ...
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Article
Open AccessLack of adipocyte IP3R1 reduces diet-induced obesity and greatly improves whole-body glucose homeostasis
The normal function of skeletal muscle and adipose tissue ensures whole-body glucose homeostasis. Ca2+ release channel inositol 1,4,5-trisphosphate receptor 1 (IP3R1) plays a vital role in regulating diet-induced...
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Article
Open AccessMetagenomic and machine learning-aided identification of biomarkers driving distinctive Cd accumulation features in the root-associated microbiome of two rice cultivars
Develo** low-cadmium (Cd) rice cultivars has emerged as a promising avenue for food safety in Cd-contaminated farmlands. The root-associated microbiomes of rice have been shown to enhance rice growth and all...
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Article
Open AccessGut microbiome dysregulation drives bone damage in broiler tibial dyschondroplasia by disrupting glucose homeostasis
Tibial dyschondroplasia (TD) with multiple incentives is a metabolic skeletal disease that occurs in fast-growing broilers. Perturbations in the gut microbiota (GM) have been shown to affect bone homoeostasis,...
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Article
Hypothalamic Grb10 enhances leptin signalling and promotes weight loss
Leptin acts on hypothalamic neurons expressing agouti-related protein (AgRP) or pro-opiomelanocortin (POMC) to suppress appetite and increase energy expenditure, but the intracellular mechanisms that modulate ...
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Article
High-plex imaging of RNA and proteins at subcellular resolution in fixed tissue by spatial molecular imaging
Resolving the spatial distribution of RNA and protein in tissues at subcellular resolution is a challenge in the field of spatial biology. We describe spatial molecular imaging, a system that measures RNAs and...
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Article
Open AccessChromosome-level genome and population genomics reveal evolutionary characteristics and conservation status of Chinese indigenous geese
Geese are herbivorous birds that play an essential role in the agricultural economy. We construct the chromosome-level genome of a Chinese indigenous goose (the **ngguo gray goose, XGG; Anser cygnoides) and analy...
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Article
Open AccessMultiscale characterization reveals oligomerization dependent phase separation of primer-independent RNA polymerase nsp8 from SARS-CoV-2
RNA replication and transcription machinery is an important drug target for fighting against coronavirus. Non-structure protein nsp8 was proposed harboring primase activity. However, the RNA primer synthesis m...
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Article
A clinically relevant model of focal embolic cerebral ischemia by thrombus and thrombolysis in rhesus monkeys
Over decades of research into the treatment of stroke, nearly all attempts to translate experimental treatments from discovery in cells and rodents to use in humans have failed. The prevailing belief is that i...
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Article
Open AccessEffects of an inhibitor of the SHH signaling pathway on endometrial cells of patients with endometriosis
Endometriosis is one of the most common gynecological diseases, and seriously reduces the quality of life of patients. However, the pathogenesis of this disease is unclear. Therefore, more studies are needed t...
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Article
Fertility conversion between cytoplasmic maintainer lines and restorer lines through molecular marker-assisted selection in pepper (Capsicum annuum L.)
Pepper commercial hybrids, produced by an economical and efficient cytoplasmic male sterility (CMS)/restorer-of-fertility (Rf) system, have been widely used in production because of their strong heterosis. Howeve...
