1,991 Result(s)
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Yan **a Chen
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Article
Brain-Targeting Emodin Mitigates Ischemic Stroke via Inhibiting AQP4-Mediated Swelling and Neuroinflammation
Failure to achieve target-specific delivery to ischemic brain sites has hampered the clinical efficacy of newly developed therapies for ischemic stroke. Emodin, an active ingredient isolated from traditional C...
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Article
A sequential feature selection approach to change point detection in mean-shift change point models
Change point detection is an important area of scientific research and has applications in a wide range of fields. In this paper, we propose a sequential change point detection (SCPD) procedure for mean-shift ...
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Article
Coaxial electrospinning of Au@silicate/poly(vinyl alcohol) core/shell composite nanofibers with non-covalently immobilized gold nanoparticles for preparing flexible, freestanding, and highly sensitive SERS substrates amenable to large-scale fabrication
As substrates for surface-enhanced Raman spectroscopy (SERS), novel core/shell composite nanofiber films were prepared by coaxial electrospinning. The shell comprised Au@silicate nanohybrids, i.e., Au nanopart...
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Open AccessSerum secretoneurin as a promising biomarker for predicting poor prognosis in intracerebral hemorrhage: A prospective cohort study
Secretoneurin may play a brain-protective role. We aim to discover the relationship between serum secretoneurin levels and severity plus neurological outcome after intracerebral hemorrhage (ICH).
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Open AccessA generalized uniform placement of alters on spherical surface (U-PASS) for visualizing general weighted networks
Network visualization is an important tool for extracting information from the structure and configuration of a network, especially when the network includes weighted edges and nodes with attribute information...
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Article
Deciphering the complex behavior of piezoelectric neuron systems through bifurcation analysis with the time-domain minimum residual method
In this study, a bifurcation analysis of the piezoelectric neuron system (PNS) is conducted utilizing the time-domain minimum residual method (TMRM). From a biophysical standpoint, integrating piezoelectric de...
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Open AccessDesigning a highly efficient type III polyketide whole-cell catalyst with minimized byproduct formation
Polyketide synthases (PKSs) are classified into three types based on their enzyme structures. Among them, type III PKSs, catalyzing the iterative condensation of malonyl-coenzyme A (CoA) with a CoA-linked star...
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Article
Double homeobox a pseudogene 8/miR-223-3p/PFN2 modulates radiosensitivity in lung cancer
Long noncoding RNA double homeobox A pseudogene 8 (DUXAP8) was revealed to facilitate lung cancer progression in vitro, but the impacts of DUXAP8 on modulating radiosensitivity have not been examined.
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Article
Exosomal LncRNA TM7SF3-AU1 Aggravates White Matter Injury via MiR-702-3p/SARM1 Signaling After Subarachnoid Hemorrhage in Rats
Subarachnoid hemorrhage (SAH) is a devastating disease associated with a high mortality and morbidity. Exosomes have been considered as a potential therapeutic target for SAH. However, the effect of exosomes i...
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Article
Open AccessRelationship between first trimester physical activity and premature rupture of membranes: a birth cohort study in Chinese women
This study aimed to examine prospective associations of different intensity levels and types of physical activity (PA) in early pregnancy with premature rupture of membranes (PROM) among Chinese pregnant women.
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Article
Silencing MFN2 Drives WNT/β-catenin Nucleation to Reduce Sorafenib Sensitivity in Hepatocellular Carcinoma Cells
Mitofusin-2 (MFN2) is a mitochondrial membrane protein that plays a critical role in regulating mitochondrial fusion and cellular metabolism. To further elucidate the impact of MFN2, this study aimed to invest...
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Article
Effect of Temperature on the Mechanical Properties, Conductivity, and Microstructure of Multi-layer Graphene/Copper Composites Fabricated by Extrusion
Copper and copper alloys are widely used in electrical, rail transit and many other fields with their excellent electric, thermal conductivity and plasticity. However, pure copper has low strength and softenin...
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Exploring the relationship between institutional legitimacy and teachers’ innovative behavior: the serial mediating effects of psychological empowerment and normative commitment
Teachers play a pivotal role in advancing student learning outcomes and nurturing creativity by continuously innovating their practices. Based on the conservation of resources theory and social exchange theory...
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Article
Open AccessBoundary quantitative characterization of the top-coal limit equilibrium zone in fully mechanized top-coal caving stope along the strike direction of working face
In the process of fully mechanized top-coal caving mining, the top-coal is affected by mining-induced stress, and the stress varies along the strike direction of working face, so the boundary position of its e...
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Article
Open AccessEvaluation of somatic copy number variation detection by NGS technologies and bioinformatics tools on a hyper-diploid cancer genome
Copy number variation (CNV) is a key genetic characteristic for cancer diagnostics and can be used as a biomarker for the selection of therapeutic treatments. Using data sets established in our previous study,...
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Open AccessSocial support, psychological capital, multidimensional job burnout, and turnover intention of primary medical staff: a path analysis drawing on conservation of resources theory
Job burnout is a prevalent and emerging challenge in the primary medical system, causing mass turnover, especially of primary medical staff. Little attention has been paid to the different dimensions of job bu...
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Article
Comparison of Long-Term Clinical Outcomes and Costs Between Transesophageal Echocardiography-Guided and X-ray-Guided Percutaneous Atrial Septal Defect Closure in Children
This study aimed to compare the long-term clinical outcomes and costs between using either transesophageal echocardiography (TEE) or X-ray fluoroscopy for Percutaneous atrial septal defect (ASD) closure in chi...
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Article
Risk factors of missed early gastric cancer in endoscopic resected population: a retrospective, case–control study
Missed early gastric cancer (MEGC) is prevalent during esophagogastroduodenoscopy (EGD), which is the first-line recommended strategy for detecting early gastric cancer (EGC). Hence, we explored the risk facto...
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Article
Open AccessJ-shaped association of the triglyceride glucose-body mass index with new-onset diabetes
The triglyceride glucose-body mass index (TyG-BMI) is a convenient and clinically significant indicator of insulin resistance. This study aims to investigate the correlation between TyG-BMI and the onset of ne...
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Article
Open AccessProstaglandin I2 signaling prevents angiotensin II-induced atrial remodeling and vulnerability to atrial fibrillation in mice
Atrial fibrillation (AF) is the most common arrhythmia, and atrial fibrosis is a pathological hallmark of structural remodeling in AF. Prostaglandin I2 (PGI2) can prevent the process of fibrosis in various tissue...
