2 Result(s)
within
Yajie Chen
Cell Biology
Immunology
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Article
Open AccessDual regulation of p53 by the ribosome maturation factor SBDS
The Shwachman-Bodian Diamond syndrome (SBDS)-associated gene, SBDS, is involved in rRNA synthesis and ribosome maturation, but the role of SBDS in cancer is largely elusive. In this study, we found that SBDS is o...
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Article
Open AccessUbiquitin ligase TRIM71 suppresses ovarian tumorigenesis by degrading mutant p53
Hotspot p53 mutants augment cancer cell proliferation, metastasis and metabolism through their gain-of-function (GOF). Ovarian cancer sustains the highest frequency of TP53 mutations, but the mechanisms underlyin...
