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Article
The inhibition of in vivo tumorigenesis of osteosarcoma (OS)-732 cells by antisense human osteopontin RNA
Osteopontin (OPN) is a secreted, non-collagenous, sialic acid-rich protein which functions by mediating cell-matrix interactions and cellular signaling via binding with integrins and CD44 receptors. An increas...
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Article
Overexpression of human osteopontin increases cell proliferation and migration in human embryo kidney-293 cells
Malignant tumors are characterized by dysregulated cell growth and the metastasis of secondary tumors. Numerous studies have documented that osteopontin (OPN) plays a key role in regulating tumor progression a...
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Article
Open AccessThe contribution of cellulosomal scaffoldins to cellulose hydrolysis by Clostridium thermocellum analyzed by using thermotargetrons
Clostridium thermocellum is a thermophilic anaerobic bacterium that degrades cellulose by using a highly effective cellulosome, a macromolecular complex consisting of multiple cellulose degrading enzymes organize...
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Article
Open AccessFunctional analysis of Flavonoid 3′,5′-hydroxylase from Tea plant (Camellia sinensis): critical role in the accumulation of catechins
Flavonoid 3′,5′-hydroxylase (F3′5′H), an important branch point enzyme in tea plant flavan-3-ol synthesis, belongs to the CYP75A subfamily and catalyzes the conversion of flavones, flavanones, dihydroflavonols...
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Article
Open AccessA novel arabinose-inducible genetic operation system developed for Clostridium cellulolyticum
Clostridium cellulolyticum and other cellulolytic Clostridium strains are natural producers of lignocellulosic biofuels and chemicals via the consolidated bioprocessing (CBP) route, and systems...
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Article
Open AccessEfficient whole-cell-catalyzing cellulose saccharification using engineered Clostridium thermocellum
Cost-efficient saccharification is one of the main bottlenecks for industrial lignocellulose conversion. Clostridium thermocellum naturally degrades lignocellulose efficiently using the cellulosome, a multiprotei...
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Article
Open AccessEffects and mechanism of dexmedetomidine on neuronal cell injury induced by hypoxia-ischemia
The present study aims to investigate the protective effects of dexmedetomidine (DMED) on hypoxia ischemia injury induced by oxygen and glucose deprivation (OGD) in PC12 and primary neuronal cells.
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Article
Open AccessDetermination of the native features of the exoglucanase Cel48S from Clostridium thermocellum
Clostridium thermocellum is considered one of the most efficient natural cellulose degraders because of its cellulosomal system. As the major exoglucanase of cellulosome in C. thermocellum, Cel48S plays key roles...
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Article
Open AccessRegulation of biomass degradation by alternative σ factors in cellulolytic clostridia
Bacteria can adjust their genetic programs via alternative σ factors to face new environmental pressures. Here, we analyzed a unique set of paralogous alternative σ factors, termed σIs, which fine-tune the regula...
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Article
Open AccessFirmicutes-enriched IS1447 represents a group of IS3-family insertion sequences exhibiting unique + 1 transcriptional slippage
Bacterial insertion sequences (ISs) are ubiquitous mobile genetic elements that play important roles in genome plasticity, cell adaptability, and function evolution. ISs of various families and subgroups conta...
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Article
Open AccessConstruction of consolidated bio-saccharification biocatalyst and process optimization for highly efficient lignocellulose solubilization
The industrial conversion of biomass to high-value biofuels and biochemical is mainly restricted by lignocellulose solubilization. Consolidated bio-saccharification (CBS) is considered a promising process for ...
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Article
Correction to: Intrathecal Epigallocatechin Gallate Treatment Improves Functional Recovery After Spinal Cord Injury by Upregulating the Expression of BDNF and GDNF
Since the publication of our article [1] it has come to our attention that there was an error in Figure 4 in which the bottom left immunochemistry panel Control/Bax was a duplication of the bottom right immuno...
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Article
Open AccessMacular pucker, an atypical clinical presentation of ocular toxoplasmosis: a case report
Ocular toxoplasmosis caused by Toxoplasma gondii is an infectious disease which is widely distributed around the world and can present with various clinic manifestations. We are here reporting an unusual case ...
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Article
Open AccessBiological cellulose saccharification using a coculture of Clostridium thermocellum and Thermobrachium celere strain A9
An anaerobic thermophilic bacterial strain, A9 (NITE P-03545), that secretes β-glucosidase was newly isolated from wastewater sediments by screening using esculin. The 16S rRNA gene sequence of strain A9 had 1...
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Article
Open AccessUltraviolet Photodetector Based on Poly(3,4-Ethylenedioxyselenophene)/ZnO Core–Shell Nanorods p-n Heterojunction
In this work, we successfully assembled an organic–inorganic core–shell hybrid p-n heterojunction ultraviolet photodetector by the electropolymerization deposition of poly(3,4-ethylenedioxyselenophene) (PEDOS)...
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Article
Open AccessBioconversion of non-food corn biomass to polyol esters of fatty acid and single-cell oils
Lignocellulose is a valuable carbon source for the production of biofuels and biochemicals, thus having the potential to substitute fossil resources. Consolidated bio-saccharification (CBS) is a whole-cell-bas...
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Article
Open AccessStructure of the transcription open complex of distinct σI factors
Bacterial σI factors of the σ70-family are widespread in Bacilli and Clostridia and are involved in the heat shock response, iron metabolism, virulence, and carbohydrate sensing. A multiplicity of σI paralogues i...
