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Long-Term Survival and Recurrence Patterns in Locally Advanced Esophageal Squamous Cell Carcinoma Patients with Pathologic Complete Response After Neoadjuvant Chemotherapy Followed by Surgery
The higher pathologic complete response (pCR) after neoadjuvant chemoradiotherapy compared with neoadjuvant chemotherapy for locally advanced esophageal squamous cell carcinoma (ESCC) has not translated into s...
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Open AccessInvestigating the Influence of Temperature and Supplementation Timing on Antifungal Efficacy in Storage Medium for Corneal Transplantation
Although antifungal supplementation reduces the fungal load in the corneal storage medium, consensus is lacking on the influence of dosing and temperature. The study aims to evaluate the impact of eye bank war...
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Thermally modulated photoelectronic synaptic behavior in HfS2/VO2 heterostructure
Neuromorphic computing is known for its efficient computational speed, low latency, and reduced power consumption, which is considered a pivotal technology to overcome the von Neumann bottleneck. Artificial sy...
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Open AccessThe acyl-CoA-binding protein VdAcb1 is essential for carbon starvation response and contributes to virulence in Verticillium dahliae
In the face of carbon, nitrogen, and phosphorus starvation, microorganisms have evolved adaptive mechanisms to maintain growth. In a previous study, we identified a protein predicted to contain acyl-CoA-bindin...
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Open AccessHealthcare delivery to patients from culturally and linguistically diverse backgrounds in emergency care: a sco** review protocol
Worldwide, the culturally and linguistically diverse (CALD) population is increasing, and is predicted to reach 405 million by 2050. The delivery of emergency care for the CALD population can be complex due to...
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Open AccessMagnetic-free chiral eigenmode spectroscopy for simultaneous sensitive measurement of optical rotary dispersion and circular dichroism
Chirality, defined by Lord Kelvin, refers to the geometric symmetry property of an object that cannot be superposed onto its mirror image using rotations and translations. The material’s chirality can be probe...
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Open AccessSynergistic induction of mitotic pyroptosis and tumor remission by inhibiting proteasome and WEE family kinases
Mitotic catastrophe (MC), which occurs under dysregulated mitosis, represents a fascinating tactic to specifically eradicate tumor cells. Whether pyroptosis can be a death form of MC remains unknown. Proteasom...
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Construction of iron oxyhydroxide/nickel sulfate hydroxide hybrid electrocatalyst for efficient oxygen evolution
Transition metal (TM) basic salts have been recognized as high-efficiency catalysts for electrocatalytic oxygen evolution reaction (OER), which is of great importance for producing clean hydrogen energy. Herei...
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Open AccessMulticenter study on clinical outcomes and poor prognostic factors in patients with Klebsiella pneumoniae bacteremia receiving cefoperazone/sulbactam treatment
Infections caused by Klebsiella pneumoniae are common and result in high mortality rates. In vitro studies demonstrated the potency of cefoperazone/sulbactam (CPZ/SUL) against Klebsiella pneumoniae. However, the ...
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Open AccessDivergent histopathological and molecular patterns in chemically induced interstitial cystitis/bladder pain syndrome rat models
Interstitial cystitis/bladder pain syndrome (IC/BPS) is a complex chronic pain disorder with an elusive etiology and nonspecific symptoms. Although numerous animal models with phenotypes similar to human disea...
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Dose–response relationship between arsenic in drinking water and mortality of urinary cancers in Taiwan
Ingested arsenic is carcinogenic to the human urinary tract, but uncertainties remain regarding the dose–response relationship. To assess dose–response relationships between arsenic ingestion and urinary cance...
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Open AccessExclusive charmonium production at the electron-ion collider in China
We investigate the exclusive \(J/\psi \) J / ψ
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FXR activation remodels hepatic and intestinal transcriptional landscapes in metabolic dysfunction-associated steatohepatitis
The escalating obesity epidemic and aging population have propelled metabolic dysfunction-associated steatohepatitis (MASH) to the forefront of public health concerns. The activation of FXR shows promise to co...
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Research Progress of Vagal Nerve Regulation Mechanism in Acupuncture Treatment of Atrial Fibrillation
Atrial fibrillation (AF) is the most common arrhythmia in clinical practice. It has a high prevalence and poor prognosis. The application of antiarrhythmic drugs and even surgery cannot completely treat the di...
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Partitions into Segal–Piatetski–Shapiro sequences
Let \(\kappa \) κ be any positive real number and
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Multiplex cerebrospinal fluid proteomics identifies biomarkers for diagnosis and prediction of Alzheimer’s disease
Recent expansion of proteomic coverage opens unparalleled avenues to unveil new biomarkers of Alzheimer’s disease (AD). Among 6,361 cerebrospinal fluid (CSF) proteins analysed from the ADNI database, YWHAG per...
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Open AccessA re-evaluation of Diaporthe: refining the boundaries of species and species complexes
Diaporthe is an important plant pathogenic genus, which also occurs as endophytes and saprobes. Many Diaporthe species that are morphologically similar proved to be genetically distinct. The current understanding...
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Analyze Accelerated Mirror Descent via High-Resolution ODEs
Mirror descent, which can be seen as generalization of gradient descent for solving constrained optimization problem, has found a variety applications in many fields. As growing demand of solving high-dimensio...
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Open AccessMitochondrial Adaptation in Skeletal Muscle: Impact of Obesity, Caloric Restriction, and Dietary Compounds
The global obesity epidemic has become a major public health concern, necessitating comprehensive research into its adverse effects on various tissues within the human body. Among these tissues, skeletal muscl...
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N-methyl-D-aspartate Receptor Subunits 2A and 2B Mediate Connexins and Pannexins in the Trigeminal Ganglion Involved in Orofacial Inflammatory Allodynia during Temporomandibular Joint Inflammation
Temporomandibular joint osteoarthritis (TMJOA) is a severe form of temporomandibular joint disorders (TMD), and orofacial inflammatory allodynia is one of its common symptoms which lacks effective treatment. N...
