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  1. Article

    Open Access

    Cyclin-dependent kinase 7 is a therapeutic target in high-grade glioma

    High-grade glioma (HGG) is an incurable brain cancer. The transcriptomes of cells within HGG tumors are highly heterogeneous. This renders the tumors unresponsive or able to adapt to therapeutics targeted at s...

    S A Greenall, Y C Lim, C B Mitchell, K S Ensbey, B W Stringer, A L Wilding… in Oncogenesis (2017)

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  2. Article

    The LIM-only transcription factor LMO2 determines tumorigenic and angiogenic traits in glioma stem cells

    Glioblastomas (GBMs) maintain their cellular heterogeneity with glioma stem cells (GSCs) producing a variety of tumor cell types. Here we interrogated the oncogenic roles of Lim domain only 2 (LMO2) in GBM and...

    S-H Kim, E-J Kim, M Hitomi, S-Y Oh, X **, H-M Jeon, S Beck… in Cell Death & Differentiation (2015)

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  3. No Access

    Article

    Oct4 is a critical regulator of stemness in head and neck squamous carcinoma cells

    Cancer stem cells (CSCs) have been suggested as responsible for the initiation and progression of cancers. Octamer-binding transcription factor 4 (Oct4) is an important regulator of embryonic stem cell fate. H...

    B S Koo, S H Lee, J M Kim, S Huang, S H Kim, Y S Rho, W J Bae, H J Kang… in Oncogene (2015)