Skip to main content

2 Result(s)

within Y. Bashir Remove this filter Cancer Research Remove this filter

and

  1. Article

    Open Access

    Waldenstrom macroglobulinemia cells devoid of BTKC481S or CXCR4WHIM-like mutations acquire resistance to ibrutinib through upregulation of Bcl-2 and AKT resulting in vulnerability towards venetoclax or MK2206 treatment

    Although ibrutinib is highly effective in Waldenstrom macroglobulinemia (WM), no complete remissions in WM patients treated with ibrutinib have been reported to date. Moreover, ibrutinib-resistant disease is b...

    A Paulus, S Akhtar, H Yousaf, A Manna, S M Paulus, Y Bashir… in Blood Cancer Journal (2017)

    Download PDF (2249 KB) View Article

  2. Article

    Open Access

    Coinhibition of the deubiquitinating enzymes, USP14 and UCHL5, with VLX1570 is lethal to ibrutinib- or bortezomib-resistant Waldenstrom macroglobulinemia tumor cells

    The survival of Waldenstrom macroglobulinemia (WM) tumor cells hinges on aberrant B-cell receptor (BCR) and MYD88 signaling. WM cells upregulate the proteasome function to sustain the BCR-driven growth while m...

    A Paulus, S Akhtar, T R Caulfield, K Samuel, H Yousaf, Y Bashir… in Blood Cancer Journal (2016)

    Download PDF (4073 KB) View Article