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  1. Article

    Open Access

    β-elemene regulates M1-M2 macrophage balance through the ERK/JNK/P38 MAPK signaling pathway

    Macrophages are classified into classically activated M1 macrophages and alternatively activated M2 macrophages, and the two phenotypes of macrophages are present during the development of various chronic dise...

    Yingyu Zhou, Tomohiro Takano, Xuyang Li, Yimei Wang, Rong Wang… in Communications Biology (2022)

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  2. Article

    Open Access

    DNMT1-mediated methylation inhibits microRNA-214-3p and promotes hair follicle stem cell differentiate into adipogenic lineages

    Dysfunction of the DNA methylation was associated with stem cell reprogramming. Moreover, DNA methyltransferase 1 (DNMT1) deficiency was involved in the differentiation of hair follicle stem cell (HFSc), but t...

    Fangcao **, Min Li, Xuyang Li, Yunpeng Zheng, Kun Zhang… in Stem Cell Research & Therapy (2020)

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  3. No Access

    Article

    Exploration of phenol tolerance mechanism through antioxidative responses of an evolved strain, Chlorella sp. L5

    Phenol is a typical pollutant which can be degraded by microalgae. Phenol induces formation of reactive oxygen species (ROS). Tolerance to oxidative damage produced by ROS is critical for phenol degradation by...

    Lin Zhou, Yizhong Yuan, Xuyang Li, Shouhua Mei, Juan Gao… in Journal of Applied Phycology (2018)

  4. No Access

    Article

    Synthetic muscle promoters: activities exceeding naturally occurring regulatory sequences

    Relatively low levels of expression from naturally occurring promoters have limited the use of muscle as a gene therapy target. Myogenic restricted gene promoters display complex organization usually involving...

    Xuyang Li, Eric M. Eastman, Robert J. Schwartz… in Nature Biotechnology (1999)

  5. No Access

    Article

    Enhanced growth by ectopic expression of growth hormone releasing hormone using an injectable myogenic vector

    Ectopic expression of a truncated growth hormone–releasing hormone (GHRH) from muscle tissues by a myogenic plasmid DNA vector directed by the skeletal α-actin promoter, pSK-GHRH, results in growth hormone (GH...

    Ruxandra Draghia-Akli, Xuyang Li, Robert J. Schwartz in Nature Biotechnology (1997)