23 Result(s)

Article

Molecular characterization of Staphylococcus aureus isolates causing skin and soft tissue infections (SSTIs)

Staphylococcus aureus, particularly methicillin-resistant S. aureus (MRSA), is an important cause of pyogenic skin and soft tissue infections (SSTIs). The aim of present study is to investigate the molecular cha...

Dan Yao, Fang-you Yu, Zhi-qiang Qin, Chun Chen, Su-su He… in BMC Infectious Diseases (2010)

Article

High prevalence of plasmid-mediated 16S rRNA methylase gene rmtB among Escherichia coliclinical isolates from a Chinese teaching hospital

Recently, production of 16S rRNA methylases by Gram-negative bacilli has emerged as a novel mechanism for high-level resistance to aminoglycosides by these organisms in a variety of geographic locations. There...

Fang-you Yu, Dan Yao, **g-ye Pan, Chong Chen, Zhi-qiang Qin… in BMC Infectious Diseases (2010)

Article

Classification of 5-HT_1A receptor agonists and antagonists using GA-SVM method

To construct a reliable computational model for the classification of agonists and antagonists of 5-HT_1A receptor.

Xue-lian Zhu, Hai-yan Cai, Zhi-jian Xu, Yong Wang… in Acta Pharmacologica Sinica (2011)

Article

Clinical and Molecular Features of 38 Children with Chronic Granulomatous Disease in Mainland China

Chronic granulomatous disease (CGD) is an inherited disorder, with phagocytes failing to produce antimicrobial superoxide due to deficient NADPH oxidase activity. Mutations in the gene encoding CYBB are respon...

Huan Xu, Wen Tian, Shu-Juan Li, Lu-Ying Zhang, Wei Liu… in Journal of Clinical Immunology (2014)

Article

Erratum to: Clinical and Molecular Features of 38 Children with Chronic Granulomatous Disease in Mainland China

Huan Xu, Wen Tian, Shu-Juan Li, Lu-Ying Zhang, Wei Liu… in Journal of Clinical Immunology (2017)

Article

Shenmai injection enhances the cytotoxicity of chemotherapeutic drugs against colorectal cancers via improving their subcellular distribution

Shenmai injection (SMI) is a Chinese patent-protected injection, which was mainly made of Red Ginseng and Radix Ophiopogonis and widely used for treating coronary heart disease and tumors by boosting Qi and no...

Wen-yue Liu, **g-wei Zhang, Xue-quan Yao, Chao Jiang… in Acta Pharmacologica Sinica (2017)

Article

Preclinical evaluation of the efficacy, pharmacokinetics and immunogenicity of JS-001, a programmed cell death protein-1 (PD-1) monoclonal antibody

JS-001 is the first monoclonal antibody (mAb) against programmed cell death protein-1 (PD-1) approved by the China Food and Drug Administration (CFDA) into the clinical trails. To date, however, no pre-clinica...

Jie Fu, Fang Wang, Li-hou Dong, **g Zhang, Cheng-lian Deng… in Acta Pharmacologica Sinica (2017)

Article

Probiotics may not prevent the deterioration of necrotizing enterocolitis from stage I to II/III

Probiotic therapy can reduce the incidence of NEC. Therapeutic use of probiotics after NEC diagnosis reduces the severity of NEC in preterm infants or full-term infants is unclear. To evaluate the effect of pr...

Zheng-Li Wang, Li Liu, **ao-Yu Hu, Lu Guo, Qiu-Yu Li, Yao An… in BMC Pediatrics (2019)

Article

Association between admission hypothermia and outcomes in very low birth weight infants in China: a multicentre prospective study

The objective of this prospective, multicentre, observational cohort study was to evaluate the association between admission hypothermia and neonatal outcomes in very low-birth weight (VLBW) infants in multipl...

Yong-hui Yu, Li Wang, Lei Huang, Li-ling Wang, **ao-yang Huang… in BMC Pediatrics (2020)

Article

Development of a risk scoring system for prognostication in HIV-related toxoplasma encephalitis

This study aims to evaluate specific risk factors influencing prognosis of HIV-infected patients with toxoplasma encephalitis (TE) in order to develop a prognostic risk scoring system for them.

Yao Li, Yan-Ming Zeng, Min Liu, Yan-Qiu Lu, Xue-Yan Liu… in BMC Infectious Diseases (2020)

Article

Single-cell RNA sequencing reveals that targeting HSP90 suppresses PDAC progression by restraining mitochondrial bioenergetics

Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest cancers, which lacks effective treatment strategies. There is an urgent need for the development of new strategies for PDAC therapy. The genetic ...

Li-Peng Hu, Kai-**a Zhou, Yan-Miao Huo, De-Jun Liu, Qing Li, Min-Wei Yang… in Oncogenesis (2021)

Article

The prevalence, relative risk factors and MTHFR C677T genotype of H type hypertension of the elderly hypertensives in Shanghai, China: a cross-section study

H type hypertension is defined as homocysteine (Hcy) ≥ 10 μmol/L in combination with primary hypertension. Studies demonstrated that the existence of hyperhomocysteine (HHcy) in hypertensive exacerbates the po...

**ao-lin Qian, Hong Cao, Jun Zhang, Zhi-hui Gu… in BMC Cardiovascular Disorders (2021)

Article

Therapeutic targets and interventional strategies in COVID-19: mechanisms and clinical studies

Owing to the limitations of the present efforts on drug discovery against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the lack of the understanding of the biological regulation mechanisms ...

Yu-Wen Zhou, Yao **e, Lian-Sha Tang, Dan Pu… in Signal Transduction and Targeted Therapy (2021)

Article

Ascorbic acid 6-palmitate modulates microglia M1/M2 polarization in lipopolysaccharide-stimulated BV-2 cells via PERK/elF2α mediated endoplasmic reticulum stress

Neuroinflammation-mediated microglia polarization is a major process in various central nervous system (CNS) diseases. Endoplasmic reticulum (ER) stress contributes to the inflammatory signals as well as to mi...

Qian Li, Yao Wu, Xue-shen Chen, Tao Zeng… in BMC Complementary Medicine and Therapies (2022)

Article

Human brucellosis and fever of unknown origin

Human brucellosis has become one of the major public health problems in China, and increases atypical manifestations, such as fever of unknown origin (FUO), and misdiagnosis rates has complicated the diagnosis...

Zhi-guo Wu, Zhi-ying Song, Wei-xin Wang, Wen-na **, Di **… in BMC Infectious Diseases (2022)

Article

Correction: Human brucellosis and fever of unknown origin

Zhi-guo Wu, Zhi-ying Song, Wei-xin Wang, Wen-na **, Di **… in BMC Infectious Diseases (2023)

Article

A Cohort Study on Deficiency of ADA2 from China

Deficiency of adenosine deaminase 2 (DADA2), an autosomal recessive autoinflammatory disorder caused by biallelic loss-of-function variants in adenosine deaminase 2 (ADA2), has not been systemically investigat...

Guo-min Li, Xu Han, Ye Wu, Wei Wang, Hong-xia Tang… in Journal of Clinical Immunology (2023)

Article

Evolving cognition of the JAK-STAT signaling pathway: autoimmune disorders and cancer

The Janus kinase (JAK) signal transducer and activator of transcription (JAK-STAT) pathway is an evolutionarily conserved mechanism of transmembrane signal transduction that enables cells to communicate with t...

Chen Xue, Qinfan Yao, **nyu Gu, Qingmiao Shi… in Signal Transduction and Targeted Therapy (2023)

Article

Effects of new hypoglycemic drugs on cardiac remodeling: a systematic review and network meta-analysis

In recent years, the incidence of diabetes mellitus has been increasing annually, and cardiovascular complications secondary to diabetes mellitus have become the leading cause of death in diabetic patients. Co...

Yi-lin Huang, **ao-zhuo Xu, **g Liu, Pin-yao Wang… in BMC Cardiovascular Disorders (2023)

Article

Acromegaly complicated with fulminant pituitary apoplexy: clinical characteristic analysis and review of literature

To retrospectively summarize the clinical features of acromegaly complicated with fulminant pituitary apoplexy and analyze the prognostic factors to guide early identification and timely treatment of such pati...

Xue-Qing Zheng, **ang Zhou, Yong Yao, Kan Deng, Hui You, Lian Duan… in Endocrine (2023)