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Article
Open AccessMitochondrial RNA modification-based signature to predict prognosis of lower grade glioma: a multi-omics exploration and verification study
Mitochondrial RNA modification (MRM) plays a crucial role in regulating the expression of key mitochondrial genes and promoting tumor metastasis. Despite its significance, comprehensive studies on MRM in lower...
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Article
Open AccessAtomic-scale observation of nucleation- and growth-controlled deformation twinning in body-centered cubic nanocrystals
Twinning is an essential mode of plastic deformation for achieving superior strength and ductility in metallic nanostructures. It has been generally believed that twinning-induced plasticity in body-centered c...
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Article
Open AccessLaminar compartmentalization of attention modulation in area V4 aligns with the demands of visual processing hierarchy in the cortex
Attention selectively enhances neural responses to low contrast stimuli in visual area V4, a critical hub that sends projections both up and down the visual hierarchy. Veridical encoding of contrast informatio...
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Article
Open AccessCarbon price prediction based on decomposition technique and extreme gradient boosting optimized by the grey wolf optimizer algorithm
It is essential to predict carbon prices precisely in order to reduce CO2 emissions and mitigate global warming. As a solution to the limitations of a single machine learning model that has insufficient forecasti...
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Article
Open AccessChromatin accessibility landscape of relapsed pediatric B-lineage acute lymphoblastic leukemia
For around half of the pediatric B-lineage acute lymphoblastic leukemia (B-ALL) patients, the molecular mechanism of relapse remains unclear. To fill this gap in knowledge, here we characterize the chromatin a...
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Article
Open AccessComprehensive analysis of cuproptosis and copper homeostasis genoty** and related immune land scape in lung adenocarcinoma
Cuproptosis is a manner of cell death which is related to the homeostasis of copper ions in the cellular environment and is expected to open a new direction of anti-tumor therapy. However, the studies on cupro...
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Article
Thyroid dysfunction after immune checkpoint inhibitor treatment in a single-center Chinese cohort: a retrospective study
Thyroid dysfunction is a common adverse event after immune checkpoint inhibitor (ICI) therapy. The clinical manifestations of thyroid immune-related adverse events (irAEs) are variable and the underlying mecha...
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Article
Open AccessPrognostic value of coronary CTA-based classifications for predicting major events without obstructive coronary artery disease
We aim to explore the classifications based on coronary computed tomography angiography (CTA) for predicting the risk of major adverse cardiovascular events (MACE) in patients with suspected non-obstructive co...
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Article
Open AccessHigh-efficiency and stable short-delayed fluorescence emitters with hybrid long- and short-range charge-transfer excitations
The pursuit of ideal short-delayed thermally activated delayed fluorescence (TADF) emitters is hampered by the mutual exclusion of a small singlet-triplet energy gap (ΔEST) and a large oscillator strength (f). He...
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Article
Open AccessLncRNA modulates Hippo-YAP signaling to reprogram iron metabolism
Iron metabolism dysregulation is tightly associated with cancer development. But the underlying mechanisms remain poorly understood. Increasing evidence has shown that long noncoding RNAs (lncRNAs) participate...
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Article
Open AccessStructural basis of the substrate recognition and inhibition mechanism of Plasmodium falciparum nucleoside transporter PfENT1
By lacking de novo purine biosynthesis enzymes, Plasmodium falciparum requires purine nucleoside uptake from host cells. The indispensable nucleoside transporter ENT1 of P. falciparum facilitates nucleoside uptak...
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Article
Open AccessFast on–off controlling of electrohydrodynamic printing based on AC oscillation induced voltage
Stability control of electrohydrodynamic (EHD) printing technology is urgent needed for efficient fabrication of flexible electronics. In this study, a new fast on–off controlling technology for micro droplets...
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Article
Open AccessMolecular diagnosis and novel genes and phenotypes in a pediatric thoracic insufficiency cohort
Thoracic insufficiency syndromes are a genetically and phenotypically heterogeneous group of disorders characterized by congenital abnormalities or progressive deformation of the chest wall and/or vertebrae th...
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Article
Open AccessOxygen mediated oxidative couplings of flavones in alkaline water
Catalyzed oxidative C-C bond coupling reactions play an important role in the chemical synthesis of complex natural products of medicinal importance. However, the poor functional group tolerance renders them unfi...
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Article
Open AccessSpectral characteristics of gold nanoparticle doped optical fibre under axial strain
Nanoparticle (NP) do** of optical fibres can be used to increase the intensity of the backscattered light used for distributed strain sensing and has shown the advantages of high precision strain detection a...
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Article
Open AccessSp1 induced gene TIMP1 is related to immune cell infiltration in glioblastoma
Tumor immune microenvironment exerts a profound effect on the population of infiltrating immune cells. Tissue inhibitor of matrix metalloproteinase 1 (TIMP1) is frequently overexpressed in a variety of cells, ...
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Article
Open AccessSelf-sustained electricity generator driven by the compatible integration of ambient moisture adsorption and evaporation
Generating sustainable electricity from ambient humidity and natural evaporation has attracted tremendous interest recently as it requires no extra mechanical energy input and is deployable across all weather ...
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Article
Open AccessAuthor Correction: GL261 luciferase-expressing cells elicit an anti-tumor immune response: an evaluation of murine glioma models
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Article
Open AccessDistinct genomic landscape of Chinese pediatric acute myeloid leukemia impacts clinical risk classification
Studies have revealed key genomic aberrations in pediatric acute myeloid leukemia (AML) based on Western populations. It is unknown to what extent the current genomic findings represent populations with differ...
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Article
Open AccessInner core composition paradox revealed by sound velocities of Fe and Fe-Si alloy
Knowledge of the sound velocity of core materials is essential to explain the observed anomalously low shear wave velocity (VS) and high Poisson’s ratio (σ) in the solid inner core. To date, neither VS nor σ of F...