105 Result(s)

Article

Identifying behaviour-related and physiological risk factors for suicide attempts in the UK Biobank

Suicide is a global public health challenge, yet considerable uncertainty remains regarding the associations of both behaviour-related and physiological factors with suicide attempts (SA). Here we first estima...

Bei Zhang, Jia You, Edmund T. Rolls, **ang Wang, Jujiao Kang… in Nature Human Behaviour (2024)

Article

Molecular insights into the inhibition of proton-activated chloride channel by transfer RNA

Pengliang Chi, **ang Wang, Jialu Li, Hui Yang, Kaiju Li, Yuqi Zhang… in Cell Research (2024)

Article

LncFASA promotes cancer ferroptosis via modulating PRDX1 phase separation

Ferroptosis, a unique type of non-apoptotic cell death resulting from iron-dependent lipid peroxidation, has a potential physiological function in tumor suppression, but its underlying mechanisms have not been...

**ao Fan, Fangzhou Liu, **ang Wang, Ying Wang, Yu Chen… in Science China Life Sciences (2024)

Article

Lymphatic endothelial-like cells promote glioblastoma stem cell growth through cytokine-driven cholesterol metabolism

Glioblastoma is the most lethal primary brain tumor with glioblastoma stem cells (GSCs) atop a cellular hierarchy. GSCs often reside in a perivascular niche, where they receive maintenance cues from endothelia...

Linjie Zhao, Zhixin Qiu, Zhengnan Yang, Lian Xu, Thomas M. Pearce… in Nature Cancer (2024)

Article

Structural basis of the subcortical maternal complex and its implications in reproductive disorders

The subcortical maternal complex (SCMC) plays a crucial role in early embryonic development. Malfunction of SCMC leads to reproductive diseases in women. However, the molecular function and assembly basis for ...

Pengliang Chi, Guo** Ou, Dandan Qin, Zhuo Han… in Nature Structural & Molecular Biology (2024)

Article

Metformin Promotes Proliferation of Mouse Female Germline Stem Cells by Histone Acetylation Modification of Traf2

Female germline stem cells (FGSCs) are adult stem cells that can both self-renew and differentiate into mature oocytes. Although small-molecule compounds are capable of regulating the development of FGSCs, the...

Jiaqi Chen, Lu Wang, Geng G. Tian, **ang Wang, **aoyong Li… in Stem Cell Reviews and Reports (2023)

Article

CircPGPEP1 promotes the growth and metastasis of breast cancer cells by targeting miR-30b

Circular RNAs (circRNAs) and microRNAs (miRNAs) are closely associated with tumorigenesis. Breast cancer is a heterogeneous disease with subtypes. It is one of the leading causes of death in women, and dysregu...

Yongjia Tan, **ang Wang in Molecular & Cellular Toxicology (2023)

Article

AF9 targets acetyl-modified STAT6 to diminish purine metabolism and accelerate cell apoptosis during metastasis

Cell migration and invasion are two important steps for tumour metastasis, and involved the behaviors including metabolism remodeling and anti-apoptosis. However, it’s still elusive that cancer cells how to an...

Jialiang Shao, Tiezhu Shi, Lianheng Chen, **ang Wang… in Cell Death & Differentiation (2023)

Article

Endocytosis of root cells induced by low-dose lanthanum(III) can promote seedling photomorphogenesis and leaf photosynthesis

Low-dose lanthanum [La(III)] promotes photosynthesis when applied to plant roots or leaves (i.e., by activating leaf endocytosis), but its mechanism remains unclear. After phenotypic transition from skotomorph...

Yunlong Jiao, Qing Yang, Lamei Liu, Junjie Pang, **ang Wang, Qing Zhou… in Plant and Soil (2023)

Article

Overexpression of CiMYC2 Transcription Factor from Chrysanthemum indicum var. aromaticum Resulted in Modified Trichome Formation and Terpenoid Biosynthesis in Transgenic Tobacco

Chrysanthemum indicum var. aromaticum (C. indicum var. aromaticum) is an important aromatic plant resource in the Chrysanthemum genus, and the main substance of its aroma is terpenoids. Myelocytomatosis 2 (MYC2) ...

Wenjie Gao, Qingran Meng, **ang Wang, Feng Chen… in Journal of Plant Growth Regulation (2023)

Article

Overexpression of GPS and FPS from Chrysanthemum indicum var. aromaticum resulted in modified trichome formation and terpenoid biosynthesis in tobacco

Geranyl diphosphate synthase (GPS) and farnesyl diphosphate synthase (FPS) catalyzes the biosynthesis of monoterpenoids and sesquiterpenoids, two key precursors for terpenoids biosynthesis. Here, the open read...

Wenjie Gao, Qingran Meng, **ang Wang, Feng Chen, Miao He… in Plant Growth Regulation (2023)