19 Result(s)
within
Woong-yang Park
Stem Cells
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Article
Open AccessThe identification of effective tumor-suppressing neoantigens using a tumor-reactive TIL TCR-pMHC ternary complex
Neoantigens are ideal targets for cancer immunotherapy because they are expressed de novo in tumor tissue but not in healthy tissue and are therefore recognized as foreign by the immune system. Advances in nex...
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Open AccessSingle cell dynamics of tumor specificity vs bystander activity in CD8+ T cells define the diverse immune landscapes in colorectal cancer
CD8+ T cell activation via immune checkpoint blockade (ICB) is successful in microsatellite instable (MSI) colorectal cancer (CRC) patients. By comparison, the success of immunotherapy against microsatellite stab...
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Open AccessLeveraging genetic overlap between irritability and psychiatric disorders to identify genetic variants of major psychiatric disorders
Irritability is a heritable core mental trait associated with several psychiatric illnesses. However, the genomic basis of irritability is unclear. Therefore, this study aimed to 1) identify the genetic varian...
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Open AccessComparison of cell type distribution between single-cell and single-nucleus RNA sequencing: enrichment of adherent cell types in single-nucleus RNA sequencing
Single-cell ribonucleic acid (RNA) sequencing (scRNA-seq) is an effective technique for estimating the cellular composition and transcriptional profiles of individual cells from fresh tissue. Single-nucleus RN...
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Open AccessA database of 5305 healthy Korean individuals reveals genetic and clinical implications for an East Asian population
Despite substantial advances in disease genetics, studies to date have largely focused on individuals of European descent. This limits further discoveries of novel functional genetic variants in other ethnic g...
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Open AccessNovel KCNQ4 variants in different functional domains confer genotype- and mechanism-based therapeutics in patients with nonsyndromic hearing loss
Loss-of-function variant in the gene encoding the KCNQ4 potassium channel causes autosomal dominant nonsyndromic hearing loss (DFNA2), and no effective pharmacotherapeutics have been developed to reverse chann...
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Open AccessTumor-promoting macrophages prevail in malignant ascites of advanced gastric cancer
Gastric cancer (GC) patients develop malignant ascites as the disease progresses owing to peritoneal metastasis. GC patients with malignant ascites have a rapidly deteriorating clinical course with short survi...
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Open AccessSingle-cell genomics technology: perspectives
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Open AccessCancer cells undergoing epigenetic transition show short-term resistance and are transformed into cells with medium-term resistance by drug treatment
To elucidate the epigenetic mechanisms of drug resistance, epigenetically reprogrammed H460 cancer cells (R-H460) were established by the transient introduction of reprogramming factors. Then, the R-H460 cells...
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Open AccessTargeted exome sequencing resolves allelic and the genetic heterogeneity in the genetic diagnosis of nephronophthisis-related ciliopathy
Nephronophthisis-related ciliopathy (NPHP-RC) is a common genetic cause of end-stage renal failure during childhood and adolescence and exhibits an autosomal recessive pattern of inheritance. Genetic diagnosis...
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Open AccessTime-course analysis of DNA damage response-related genes after in vitro radiation in H460 and H1229 lung cancer cell lines
Radiation is the most useful treatment modality for cancer patients. It initiates a series of signal cascades such as DNA damage response (DDR) signaling for repairing damaged DNA, arresting the cell cycle, an...
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Open AccessmiR-9 and let-7g enhance the sensitivity to ionizing radiation by suppression of NFκB1
The activation of nuclear factor-kappa B1 (NFκB1) in cancer cells may confer resistance to ionizing radiation (IR). To enhance the therapeutic efficiency of IR in lung cancer, we screened for microRNAs (miRNAs...
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Open AccessLIN28B confers radio-resistance through the posttranscriptional control of KRAS
To screen the differentially expressed microRNAs related to radio-resistance, we compared the microRNA profiles of lung cancer cells with different responses to ionizing radiation (IR). Of 328 microRNAs in mic...
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Open AccessChemical inhibitors destabilize HuR binding to the AU-rich element of TNF-α mRNA
Hu protein R (HuR) binds to the AU-rich element (ARE) in the 3'UTR to stabilize TNF-α mRNA. Here, we identified chemical inhibitors of the interaction between HuR and the ARE of TNF-α mRNA using RNA electropho...
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Open AccessComprehensive analysis of microRNA-mRNA co-expression in circadian rhythm
To investigate the potential role of microRNA (miRNA) in the regulation of circadian rhythm, we performed microarray-based expression profiling study of both miRNA and mRNA in mouse liver for 48 h at 4-hour in...
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Open AccessErratum: Local exposure of 849 MHz and 1763 MHz radiofrequency radiation to mouse heads does not induce cell death or cell proliferation in brain
Correction to: Experimental & Molecular Medicine (2008) 40, 294–303; doi:10.3858/emm.2008.40.3.294 The authors would like to amend the name of Tae-Hyoung Kim1 Tae-Hyung Kim1 The authors apologize for any incon...
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Open AccessLocal exposure of 849 MHz and 1763 MHz radiofrequency radiation to mouse heads does not induce cell death or cell proliferation in brain
Even though there is no direct evidence to prove the cellular and molecular changes induced by radiofrequency (RF) radiation itself, we cannot completely exclude the possibility of any biological effect of mob...
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Open AccessCaveolin-1 upregulation in senescent neurons alters amyloid precursor protein processing
Lipid rafts provide a platform for regulating cellular functions and participate in the pathogenesis of several diseases. However, the role of caveolin-1 in this process has not been elucidated definitely in n...
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Open AccessObesity and genetic polymorphism of ERCC2 and ERCC4 as modifiers of risk of breast cancer
To evaluate the relationship of genetic polymorphisms of ERCC2 and ERCC4 genes, both involved in nucleotide excision repair (NER), and the risk of breast cancer, a hospital-based case-control study was conduct...
