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  1. No Access

    Article

    Modeling Smith-Lemli-Opitz syndrome with induced pluripotent stem cells reveals a causal role for Wnt/β-catenin defects in neuronal cholesterol synthesis phenotypes

    Analysis of SLOS patient-derived iPSCs reveals that cellular accumulation of the cholesterol precursor 7DHC, rather than cholesterol deficiency, causes dysregulation of Wnt/β-catenin signaling and aberrant neu...

    Kevin R Francis, Amy N Ton, Yao **n, Peter E O'Halloran… in Nature Medicine (2016)

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    Article

    Blockade of eosinophil migration and airway hyperresponsiveness by cPLA2-inhibition

    We examined the role of a cytosolic phospholipase A2 (cPLA2) in antigen-induced eosinophil infiltration of airways and in airway hyperresponsiveness to methacholine. Inhibition of cPLA2, or blockade of the platel...

    Shigeharu Myou, Hiroyuki Sano, Masaki Fujimura, **angdong Zhu… in Nature Immunology (2001)