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  1. No Access

    Article

    Iron–sulphur cluster biogenesis and mitochondrial iron homeostasis

    Iron–sulphur clusters are important cofactors for proteins that are involved in many cellular processes, including electron transport, enzymatic catalysis and regulation. The enzymes that catalyse the formatio...

    Tracey A. Rouault, Wing-Hang Tong in Nature Reviews Molecular Cell Biology (2005)

  2. No Access

    Article

    Metabolic regulation of citrate and iron by aconitases: role of iron–sulfur cluster biogenesis

    Iron and citrate are essential for the metabolism of most organisms, and regulation of iron and citrate biology at both the cellular and systemic levels is critical for normal physiology and survival. Mitochon...

    Wing-Hang Tong, Tracey A. Rouault in BioMetals (2007)

  3. Article

    Open Access

    Aberrant iron homeostasis, oxidative fiber enrichment, and activation of ketogenesis in muscle tissue of ISCU Myopathy patients

    Daniel R Crooks, Thanemozhi G Natarajan, Churning Chen, Hongzhan Huang… in BMC Proceedings (2012)

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  4. Article

    Open Access

    Heme biosynthesis depends on previously unrecognized acquisition of iron-sulfur cofactors in human amino-levulinic acid dehydratase

    Heme biosynthesis and iron-sulfur cluster (ISC) biogenesis are two major mammalian metabolic pathways that require iron. It has long been known that these two pathways interconnect, but the previously describe...

    Gang Liu, Debangsu Sil, Nunziata Maio, Wing-Hang Tong… in Nature Communications (2020)

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