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Article
Open AccessComparative genomics of the social amoebae Dictyostelium discoideum and Dictyostelium purpureum
The social amoebae (Dictyostelia) are a diverse group of Amoebozoa that achieve multicellularity by aggregation and undergo morphogenesis into fruiting bodies with terminally differentiated spores and stalk ce...
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Article
Open AccessLaunching genomics into the cloud: deployment of Mercury, a next generation sequence analysis pipeline
Massively parallel DNA sequencing generates staggering amounts of data. Decreasing cost, increasing throughput, and improved annotation have expanded the diversity of genomics applications in research and clin...
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Article
Analysis commons, a team approach to discovery in a big-data environment for genetic epidemiology
The increasing volume of whole-genome sequence (WGS) and multi-omics data requires new approaches for analysis. As one solution, we have created the cloud-based Analysis Commons, which brings together genotype...
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Article
Open AccessGenoty**, sequencing and analysis of 140,000 adults from Mexico City
The Mexico City Prospective Study is a prospective cohort of more than 150,000 adults recruited two decades ago from the urban districts of Coyoacán and Iztapalapa in Mexico City1. Here we generated genotype and ...
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Open AccessAuthor Correction: Genoty**, sequencing and analysis of 140,000 adults from Mexico City
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Open AccessA deep catalogue of protein-coding variation in 983,578 individuals
Rare coding variants that substantially affect function provide insights into the biology of a gene1–3. However, ascertaining the frequency of such variants requires large sample sizes4–8. Here we present a catal...