4 Result(s)
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Article
Open AccessMap** mitochondrial heteroplasmy in a Leydig tumor by laser capture micro-dissection and cycling temperature capillary electrophoresis
The growth of tumor cells is accompanied by mutations in nuclear and mitochondrial genomes creating marked genetic heterogeneity. Tumors also contain non-tumor cells of various origins. An observed somatic mit...
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Article
Open AccessThe study of calcified atherosclerotic arteries: an alternative to evaluate the composition of a problematic tissue reveals new insight including metakaryotic cells
Calcifications of atherosclerotic plaques represent a controversial issue as they either lead to the stabilization or rupture of the lesion. However, the cellular key players involved in the progression of the...
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Chapter
Mutation in Single-Cell Systems Induced by Low-Level Mutagen Exposure
A principal question currently facing toxicologists and radio-biologists concerns how measurements can be made of mutations induced by low levels of chemicals or radiation. In this paper, we focus on measureme...
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Chapter
Analysis of Chemically Induced Mutation in Single Cell Populations
This discussion is about tools to analyze the complex relationship between chemicals and mutation in a relatively simple biological system: the exponentially growing single cell population. Three assumptions a...
