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Article
Open AccessRare de novo damaging DNA variants are enriched in attention-deficit/hyperactivity disorder and implicate risk genes
Research demonstrates the important role of genetic factors in attention-deficit/hyperactivity disorder (ADHD). DNA sequencing of families provides a powerful approach for identifying de novo (spontaneous) var...
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Article
Synthesis of Mn-ZIF-67 for efficient degradation of tetracycline
Antibiotics are extensively employed in the treatment of human and animal ailments. However, their excessive use and poor biodegradability have led to a notable accumulation of antibiotics in the environment, ...
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Article
Open AccessHeavy magnesium isotopic signatures in arc lavas may be attributed to dehydration of subducting hydrated mantle
Fluids released from subducting slabs profoundly affect mantle composition, rock melting points, and arc magma generation. However, identifying fluid sources (sediments, crust, or mantle) and their ascent path...
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Article
Changes of Facial Lipidomics by Intense Pulsed Light Treatment Based on LC-MS
Intense pulsed light (IPL) has been widely used to improve cutaneous photoaging in recent years. Several studies began to explore the changes of skin barrier function after treatment, but the changes of skin s...
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Article
Deep graph-level clustering using pseudo-label-guided mutual information maximization network
In this work, we study the problem of partitioning a set of graphs into different groups such that the graphs in the same group are similar while the graphs in different groups are dissimilar. This problem was...
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Article
Immune landscape and response to oncolytic virus-based immunotherapy
Oncolytic virus (OV)-based immunotherapy has emerged as a promising strategy for cancer treatment, offering a unique potential to selectively target malignant cells while sparing normal tissues. However, the i...
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Article
Piperazine-derived ionizable lipids for enhanced mRNA delivery and cancer immunotherapy
Messenger ribonucleic acid (mRNA)-based therapeutics hold great prospects in disease treatment and lipid nanoparticles (LNPs) are the most extensively applied non-viral platform for RNA delivery in clinics. De...
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Article
C9orf72 controls hepatic lipid metabolism by regulating SREBP1 transport
Sterol regulatory element binding transcription factors (SREBPs) play a crucial role in lipid homeostasis. They are processed and transported to the nucleus via COPII, where they induce the expression of lipog...
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Article
Open AccessTwo-dimensional materials for future information technology: status and prospects
Over the past 70 years, the semiconductor industry has undergone transformative changes, largely driven by the miniaturization of devices and the integration of innovative structures and materials. Two-dimensi...
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Article
Identification and Functional Investigation of Hub Genes Associated with Follicular Lymphoma
Follicular lymphoma (FL), the most common type of indolent lymphoma, originates from germinal center B cells within the lymphoid follicle. However, the underlying mechanisms of this disease remain unclear. Thi...
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Article
Research on triazine-based nitrogen-doped porous carbon/Pebax mixed-matrix membranes for CO2 separation and its gas transport mechanism
Nitrogen-doped porous carbon (NPC) has a rich microporous structure and nitrogen-rich units, and its nitrogen-containing group can interact strongly with the PEO chain segment of Pebax, synergistically improvi...
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Article
Open AccessApplication of a hybrid algorithm of LSTM and Transformer based on random search optimization for improving rainfall-runoff simulation
Flood forecasting using traditional physical hydrology models requires consideration of multiple complex physical processes including the spatio-temporal distribution of rainfall, the spatial heterogeneity of ...
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Article
Open AccessEarly planetesimal differentiation and late accretion shaped Earth’s nitrogen budget
The relative roles of protoplanetary differentiation versus late accretion in establishing Earth’s life-essential volatile element inventory are being hotly debated. To address this issue, we employ first-prin...
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Article
Open AccessThe association between humidex and tuberculosis: a two-stage modelling nationwide study in China
Under a changing climate, the joint effects of temperature and relative humidity on tuberculosis (TB) are poorly understood. To address this research gap, we conducted a time-series study to explore the joint ...
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Article
Open AccessComparative study of melasma in patients before and after treatment based on lipomics
Skin barrier alterations play a crucial function in melasma development. Past researches have demonstrated variations in lipid content between the epidermis of melasma lesions and normal tissues, along with th...
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Article
Open AccessFree-standing ultrathin silicon wafers and solar cells through edges reinforcement
Crystalline silicon solar cells with regular rigidity characteristics dominate the photovoltaic market, while lightweight and flexible thin crystalline silicon solar cells with significant market potential hav...
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Article
Conversion of magnetron-sputtered sacrificial intermediate layer into a stable FeCo-LDH catalyst for oxygen evolution reaction
Controllable and scalable preparation of electrocatalyst materials holds significant importance for their practical application. Magnetron sputtering is a highly effective synthesis method, known for its produ...
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Article
Experimental Study of Alkali-Activated Slag Crushed Aggregate Blocks During and After Exposure to Elevated Temperatures
Nowadays, significant research effort is being dedicated to explore environmentally friendly block materials with high strength and high-temperature resistance. Ground-granulated blast-furnace slag (GGBFS) is ...
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Article
FPGA-based downhole real-time inversion of petrophysical information for NMR-LWD tools with periodic thermal management
In this brief, a real-time inversion of petrophysical information in downhole firmware for nuclear magnetic resonance logging while drilling (NMR-LWD) based on a field-programmable gate array (FPGA) is propose...
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Article
Definition of refractory melasma and its treatment: a review
Although patients with refractory melasma have been treated using various methods, there is still no precise definition or summary of the therapies. To define refractory melasma and conduct a review of the tre...
