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Article
Open AccessRescue of nucleus pulposus cells from an oxidative stress microenvironment via glutathione-derived carbon dots to alleviate intervertebral disc degeneration
The senescence of nucleus pulposus (NP) cells (NPCs), which is induced by the anomalous accumulation of reactive oxygen species (ROS), is a major cause of intervertebral disc degeneration (IVDD). In this resea...
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Article
Effect of Cu do** on structure, morphology, and microwave absorption performance of MnO2
Do** is an effective method to modify the physical and chemical properties of materials by altering their local lattice structure and electronic structure. Herein, manganese dioxide (MnO2) was modified with Cu,...
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Article
Open AccessEffect of temperature and humidity on mechanical properties and constitutive modeling of pressure-sensitive adhesives
Pressure-sensitive adhesives (PSAs) are crucial for the structural and functional integrity of flexible displays. Investigating the intricate mechanical properties of PSAs can help enhance product quality and ...
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Article
Open AccessCompressive confocal microscopy imaging at the single-photon level with ultra-low sampling ratios
Laser-scanning confocal microscopy serves as a critical instrument for microscopic research in biology. However, it suffers from low imaging speed and high phototoxicity. Here we build a novel deep compressive...
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Article
Open AccessCaffeic acid phenethyl ester derivative exerts remarkable anti-hepatocellular carcinoma effect, non-inferior to sorafenib, in vivo analysis
Caffeic acid phenethyl ester (CAPE) and its derivatives exhibit considerable effects against hepatocellular carcinoma (HCC), with unquestioned safety. Here we investigated CAPE derivative 1ʹ (CAPE 1ʹ) monotherapy...
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Article
Variations in Iron-bound carbon in Scirpus mariqueter rhizosphere and bulk soils across different salinities and tidal elevations
The objective of this study was to investigate the response of the iron (Fe) (hydr-) oxides-bounded organic carbon (Fe-OC) process, characterized by the interaction of Fe (hydr-) oxides with soil organic carbo...
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Article
Three-stage Dynamic Brain-cognitive Model of Understanding Action Intention Displayed by Human Body Movements
The ability to comprehend the intention conveyed through human body movements is crucial for effective interpersonal interactions. If people can’t understand the intention behind other individuals’ isolated or...
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Article
Multi-pool chemical exchange saturation transfer MRI in glioma grading, molecular subty** and evaluating tumor proliferation
To evaluate the performance of multi-pool Chemical exchange saturation transfer (CEST) MRI in prediction of glioma grade, isocitrate dehydrogenase (IDH) mutation, alpha-thalassemia/mental retardation syndrome ...
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Article
Cross-ancestry genome-wide association studies of brain imaging phenotypes
Genome-wide association studies of brain imaging phenotypes are mainly performed in European populations, but other populations are severely under-represented. Here, we conducted Chinese-alone and cross-ancest...
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Article
Long-term effects of childhood single-parent family structure on brain connectivity and psychological well-being
The high and increasing proportion of single-parent families is considered a risk factor associated with various childhood trauma experiences. Consequently, concerns have been raised regarding the potential lo...
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Article
Investigating the Connections Between Short-Selling Deregulation and Green Total Factor Productivity: Empirical Insights from China
China’s economic development has undergone significant transformations in recent years, focusing on quality-driven development and constructing a modern market-oriented economic system. Central to this transfo...
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Article
Open AccessReduction of specific enterocytes from loss of intestinal LGR4 improves lipid metabolism in mice
Whether intestinal Leucine-rich repeat containing G-protein-coupled receptor 4 (LGR4) impacts nutrition absorption and energy homeostasis remains unknown. Here, we report that deficiency of Lgr4 (Lgr4iKO) in inte...
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Article
Open AccessCorrection: Thermosensitive hydrogel with emodin-loaded triple-targeted nanoparticles for a rectal drug delivery system in the treatment of chronic non-bacterial prostatitis
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Article
Open AccessHAP40 modulates mutant Huntingtin aggregation and toxicity in Huntington’s disease mice
Huntington’s disease (HD) is a monogenic neurodegenerative disease, caused by the CAG trinucleotide repeat expansion in exon 1 of the Huntingtin (HTT) gene. The HTT gene encodes a large protein known to interact ...
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Article
Microstructure and Properties of Dissimilar Butt Joints of Aluminum to Copper by Cold Metal Transfer with Preheating
The dissimilar butt joining of aluminum alloy and copper was successfully realized by cold metal transfer (CMT) welding–brazing with the help of preheating on copper. Preheating could balance the effect of the...
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Article
CircSSBP2 acts as a MiR-2400 sponge to promote intramuscular preadipocyte proliferation by regulating NDRG1
Intramuscular fat (IMF) is a critical factor in beef quality. IMF is mainly distributed between muscle fibres and its accumulation can affect the marbling and meat quality of beef. IMF formation and deposition...
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Article
Open AccessShort-term evolution pattern in salt marsh landscapes: the importance of physical constraints
Salt marsh landscapes at the land-sea interfaces exhibit contrasting spatiotemporal dynamics, resulting from varying physical constraints that limit new marsh establishment. The expansion of salt marsh landsca...
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Article
Effects of the Extrusion Ratio on the Microstructure and Mechanical Properties of Columnar Network Structured TiBw/TA15 Composites
Novel columnar network structure TiB whisker-reinforced TA15 titanium alloy matrix composites (TiBw/TA15 composites) were successfully prepared by low-energy ball milling and subsequent powder compact extrusio...
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Article
Large-scale functional network connectivity mediates the association between nigral neuromelanin hypopigmentation and motor impairment in Parkinson’s disease
Neuromelanin hypopigmentation within substantia nigra pars compacta (SNc) reflects the loss of pigmented neurons, which in turn contributes to the dysfunction of the nigrostriatal and striato-cortical pathways...
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Article
Spatiotemporal patterns of brain iron-oxygen metabolism in patients with Parkinson’s disease
Iron deposition and mitochondrial dysfunction are closely associated with the genesis and progression of Parkinson’s disease (PD). This study aims to extract susceptibility and oxygen extraction fraction (OEF)...
