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Open AccessFracture healing in a polytrauma rat model is influenced by mtDNA:cGAS complex mediated pro-inflammation
The mitochondrial DNA (mtDNA) activated cyclic guanosine monophosphate–adenosine monophosphate synthase—stimulator of interferon genes (cGAS-STING) signaling pathway is a key player in mediating immune respons...
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Article
Open AccessPreclinical evaluation of a commercially available biofilm disrupting wound lavage for musculoskeletal trauma
Treatment of open fractures remains a significant challenge in trauma care as these fractures are accompanied by extensive soft tissue damage, exposing the wound site to contaminants and increasing infection r...
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Article
Open AccessNeutralization of HMGB1 improves fracture healing and γδ T lymphocyte counts at the fracture site in a polytrauma rat model
Delayed fracture healing is a common consequence of polytrauma (PT) occurring in patients with multiple injuries. We believe that when early release of high mobility group box 1 (HMGB1) molecules from necrotic...
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Article
Open AccessAdministration of a selective retinoic acid receptor-γ agonist improves neuromuscular strength in a rodent model of volumetric muscle loss
Volumetric muscle loss is a uniquely challenging pathology that results in irrecoverable functional deficits. Furthermore, a breakthrough drug or bioactive factor has yet to be established that adequately impr...
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Article
Open AccessBurn and thoracic trauma alters fracture healing, systemic inflammation, and leukocyte kinetics in a rat model of polytrauma
Singular traumatic insults, such as bone fracture, typically initiate an appropriate immune response necessary to restore the host to pre-insult homeostasis with limited damage to self. However, multiple concu...
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Article
Open AccessLocal control of polymicrobial infections via a dual antibiotic delivery system
Contaminated traumatic open orthopedic wounds are frequently complicated by polymicrobial contamination and infection. In high-risk wounds, the standard of care comprises debridement and irrigation combined wi...
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Article
Open AccessTacrolimus as an adjunct to autologous minced muscle grafts for the repair of a volumetric muscle loss injury
Volumetric muscle loss (VML) following extremity orthopaedic trauma or surgery results in chronic functional deficits and disability. A current translational approach to address the devastating functional limi...
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Article
Pediatric central nervous system hemangioblastomas: different from adult forms? A retrospective series of 25 cases
Pediatric hemangioblastomas are rare, and the clinical features, timing of surgical intervention, optimal treatment, and clinical outcomes are still unclear.
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Article
Nerve atrophy in trigeminal neuralgia due to neurovascular compression and its association with surgical outcomes after microvascular decompression
Idiopathic trigeminal neuralgia (TN) is caused by neurovascular compression and is often related to morphological changes in the trigeminal nerve. The aim of this study was to quantitatively measure atrophic c...
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Open AccessInjectable and compression-resistant low-viscosity polymer/ceramic composite carriers for rhBMP-2 in a rabbit model of posterolateral fusion: a pilot study
The challenging biological and mechanical environment of posterolateral fusion (PLF) requires a carrier that spans the transverse processes and resists the compressive forces of the posterior musculature. The ...
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Article
Open AccessCombat-related bridge synostosis versus traditional transtibial amputation: comparison of military-specific outcomes
The aim of our study was to determine military-specific outcomes for transtibial amputations of US Service members using either the traditional technique (Burgess) or the Ertl technique. All US Service member...
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Article
d-amino Acid Inhibits Biofilm but not New Bone Formation in an Ovine Model
Infectious complications of musculoskeletal trauma are an important factor contributing to patient morbidity. Biofilm-dispersive bone grafts augmented with d-amino acids (d-AAs) prevent biofilm formation in vitro...
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Article
ICAM1 depletion reduces spinal metastasis formation in vivo and improves neurological outcome
Clinical treatment of spinal metastasis is gaining in complexity while the underlying biology remains unknown. Insufficient biological understanding is due to a lack of suitable experimental animal models. Int...
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Article
Rifamycin Derivatives Are Effective Against Staphylococcal Biofilms In Vitro and Elutable From PMMA
Local antimicrobial delivery through polymethylmethacrylate beads (PMMA), commonly vancomycin, is used for the treatment of contaminated open fractures but has limited activity against Staphylococcus aureus biofi...
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Article
Mortality in Female War Veterans of Operations Enduring Freedom and Iraqi Freedom
Combat-wounded service members are surviving battle injuries more than ever. Given different combat roles held by men and women, female service members should survive wounds at an unprecedented rate.
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Article
Das G-DRG-System 2006
Das G-DRG-System der Version 2006 liegt vor. Der Kalkulations- und Anpassungsprozess für 2006 ist abgeschlossen. Dieser Beitrag beschreibt und kommentiert die wesentlichen Änderungen der G-DRG-Version 2006 und...