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    SUMOylation of RNF146 results in Axin degradation and activation of Wnt/β-catenin signaling to promote the progression of hepatocellular carcinoma

    Aberrant SUMOylation contributes to the progression of hepatocellular carcinoma (HCC), yet the molecular mechanisms have not been well elucidated. RING-type E3 ubiquitin ligase RNF146 is a key regulator of the...

    Wenjia Li, Qingfang Han, Yuanxin Zhu, Yingshi Zhou, **gyuan Zhang, Weijun Wu… in Oncogene (2023)