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    Pnpt1 mediates NLRP3 inflammasome activation by MAVS and metabolic reprogramming in macrophages

    Polyribonucleotide nucleotidyltransferase 1 (Pnpt1) plays critical roles in mitochondrial homeostasis by controlling mitochondrial RNA (mt-RNA) processing, trafficking and degradation. Pnpt1 deficiency results...

    Chia George Hsu, Wenjia Li, Mark Sowden… in Cellular & Molecular Immunology (2023)