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Open AccessACE2 mediates tryptophan alleviation on diarrhea by repairing intestine barrier involved mTOR pathway
The membrane-delimited receptor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), angiotensin-converting enzyme 2 (ACE2), which is expressed in the intestine, collaborates with broad neutral am...
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Open AccessOchratoxin A induces abnormal tryptophan metabolism in the intestine and liver to activate AMPK signaling pathway
Ochratoxin A (OTA) is a mycotoxin widely present in raw food and feed materials and is mainly produced by Aspergillus ochraceus and Penicillium verrucosum. Our previous study showed that OTA principally induces l...
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Open AccessNotch mediates the glycolytic switch via PI3K/Akt signaling to support embryonic development
Energy metabolism disorder or insufficient energy supply during incubation will affect the development and survival of avian embryos. Especially, β-oxidation could not provide the continuous necessary energy f...
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Open AccessMaternal zinc alleviates tert-butyl hydroperoxide-induced mitochondrial oxidative stress on embryonic development involving the activation of Nrf2/PGC-1α pathway
Mitochondrial dysfunction induced by excessive mitochondrial reactive oxygen species (ROS) damages embryonic development and leads to growth arrest.
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Open AccessOchratoxin A induces liver inflammation: involvement of intestinal microbiota
Ochratoxin A (OTA) is a widespread mycotoxin and induces liver inflammation to human and various species of animals. The intestinal microbiota has critical importance in liver inflammation; however, it remains...
