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Internal Medicine
Pharmacology/Toxicology
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Article
Variability in Declining Haloperidol and Reduced Haloperidol Plasma Concentrations upon Haloperidol Cessation
Plasma concentrations of haloperidol and its reduced metabolite were measured in 6 schizophrenic patients after discontinuation of oral haloperidol treatment. Patients were on haloperidol 10mg twice daily for ...
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Article
Pharmacokinetics and Pharmacodynamics of Clozapine
The introduction of clozapine has given clinicians a unique agent for treating patients with schizophrenia that is refractory to other neuroleptics. Despite its efficacy, the drug continues to be prescribed wi...
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Article
Effects of Time of Administration and Posture on the Pharmacokinetics of Cefprozil
The effects of time of administration, sleep and posture on the pharmacokinetics of cefprozil were evaluated in a single-dose 3-way crossover study. After a 6-hour fast, 12 healthy male volunteers received ora...
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Article
Formation of Reduced Haloperidol after Intramuscular Haloperidol Administration in Schizophrenic Patients
The formation of the reduced metabolite of haloperidol — reduced haloperidol (RH) — was evaluated after intramuscular haloperidol injection in 13 chronic schizophrenic patients. After an overnight fast, each p...
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Article
Comparative Study of Teicoplanin vs Vancomycin for the Treatment of Methicillin-Resistant Staphylococcus aureus Bacteraemia
Forty patients with methicillin-resistant Staphylococcus aureus (MRSA) bacteraemia were randomised to receive either teicoplanin or vancomycin therapy to compare the clinical efficacy and safety of these glycopep...
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Chapter
Catecholamine-Derived Aldehyde Neurotoxins
Catecholamine derived aldehydes are the products of monoamine oxidase (MAO) action on catecholamines (CA). There are three major CA in human tissues: norepinephrine (NE), epinephrine (Epi), and dopamine (DA). ...
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Article
Glucocorticoids and TGF-β1 Synergize in Augmenting Fibroblast Mediated Contraction of Collagen Gels
TGF-β plays a central role in the initiation and progression of pulmonary fibrosis. Glucocorticoids are frequently used to treat fibrotic diseases, but beneficial effects are often modest. Both TGF-β and gluco...
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Article
Comparison of Pharmacokinetics of Lanoteplase and Alteplase During Acute Myocardial Infarction
Lanoteplase is a rationally designed variant of tissue plasminogen activator. The aim of this study was to examine the pharmacokinetics and functional activity of a single intravenous bolus dose of lanoteplase...
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Article
Glucocorticoids Modulate TGF-β Production
TGF-β is thought to play a central role in pulmonary fibrosis inducing fibroblast differentiation and extracellular matrix synthesis. In human lung fibroblasts, it is still unclear how various TGB-β isoforms a...
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Article
Glucocorticoids Modulate TGF-β Production by Human Fetal Lung Fibroblasts
TGF-β is thought to play a central role in pulmonary fibrosis inducing fibroblast differentiation and extracellular matrix synthesis. In human lung fibroblasts, it is still unclear how various TGF-β isoforms a...
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Article
IL-4 and IL-13 Induce Chemotaxis of Human Foreskin Fibroblasts, But Not Human Fetal Lung Fibroblasts
Through shared receptors, IL-4 and IL-13 have been suggested to regulate not only inflammatory cells, but also to play a role in stimulating fibroblasts during fibrotic processes. Previous studies have shown t...
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Article
Using support vector classification for SAR of fentanyl derivatives
To discriminate between fentanyl derivatives with high and low activities.
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Article
Intrathecal administration of roscovitine inhibits Cdk5 activity and attenuates formalin-induced nociceptive response in rats
To investigate effects of the cyclin-dependent kinase5 (Cdk5) inhibitor roscovitine on formalin-induced nociceptive responses in rats.
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Article
Hypoglycemic effect of Astragalus polysaccharide and its effect on PTP1B
To examine the effects of Astragalus polysaccharide (APS), a component of an aqueous extract of Astragalus membranaceus roots, on protein tyrosine phosphatase 1B (PTP1B), a negative regulator of insulin-receptor ...
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Article
Inhibition of STAT3 expression by siRNA suppresses growth and induces apoptosis in laryngeal cancer cells
To determine the inhibitory effect of the synthetic STAT3 siRNA on the expression of STAT3 gene in human laryngeal cancer cell lines Hep2 and to investigate the effect of STAT3 siRNA on growth and apoptosis in...
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Article
The anti-endotoxic effect of o-aminobenzoic acid from Radix Isatidis
To study the anti-endotoxic effect of o-aminobenzoic acid (OABA) isolated from Banlangen(BLG).
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Article
Transforming growth factor-β1 gene polymorphisms associated with chronic obstructive pulmonary disease in Chinese population
To determine the frequencies of polymorphism and haplotype in the transforming growth factor-beta 1 (TGF-β1) gene promoter in the Chinese population and to investigate the susceptibility of this population to ...
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Article
Efficacy and Safety of Olmesartan in the Treatment of Mild-to-Moderate Essential Hypertension in Chinese Patients
Background and objective: Hypertension is very prevalent in the Chinese population in Taiwan. Chinese people frequently experience bothersome cough when receiving angiotensin-converting enzyme (A...
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Article
Relationship between leukocyte count and angiographical characteristics of coronary atherosclerosis
To explore the relationship between differential leucocyte count and coronary atherosclerosis.
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Article
Role of arachidonic acid in hyposmotic membrane stretch-induced increase in calcium-activated potassium currents in gastric myocytes
To study effects of arachidonic acid (AA) and its metabolites on the hyposmotic membrane stretch-induced increase in calcium-activated potassium currents (IKCa) in gastric myocytes.
